Combination of Human Leukocyte Antigen and Killer Cell Immunoglobulin-Like Receptor Genetic Background Influences the Onset Age of Hepatocellular Carcinoma in Male Patients with Hepatitis B Virus Infection
To investigate whether killer cell immunoglobulin-like receptor (KIR) and human leukocyte antigen (HLA) genetic background could influence the onset age of hepatocellular carcinoma (HCC) in patients with hepatitis B virus (HBV) infection, one hundred and seventy-one males with HBV-related HCC were e...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/874514 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832552852424228864 |
|---|---|
| author | Ning Pan Jie Qiu Hang Sun Fengqin Miao Qian Shi Jinhuan Xu Wei Jiang Hui Jin Wei Xie Youji He Jianqiong Zhang |
| author_facet | Ning Pan Jie Qiu Hang Sun Fengqin Miao Qian Shi Jinhuan Xu Wei Jiang Hui Jin Wei Xie Youji He Jianqiong Zhang |
| author_sort | Ning Pan |
| collection | DOAJ |
| description | To investigate whether killer cell immunoglobulin-like receptor (KIR) and human leukocyte antigen (HLA) genetic background could influence the onset age of hepatocellular carcinoma (HCC) in patients with hepatitis B virus (HBV) infection, one hundred and seventy-one males with HBV-related HCC were enrolled. The presence of 12 loci of KIR was detected individually. HLA-A, -B, and -C loci were genotyped with high resolution by a routine sequence-based typing method. The effect of each KIR locus, HLA ligand, and HLA-KIR combination was examined individually by Kaplan-Meier (KM) analysis. Multivariate Cox hazard regression model was also applied. We identified C1C1-KIR2DS2/2DL2 as an independent risk factor for earlier onset age of HCC (median onset age was 44 for C1C1-KIR2DS2/2DL2 positive patients compared to 50 for negative patients, P=0.04 for KM analysis; HR = 1.70, P=0.004 for multivariate Cox model). We conclude that KIR and HLA genetic background can influence the onset age of HCC in male patients with HBV infection. This study may be useful to improve the current HCC surveillance program in HBV-infected patients. Our findings also suggest an important role of natural killer cells (or other KIR-expressing cells) in the progress of HBV-related HCC development. |
| format | Article |
| id | doaj-art-5d929b4c79d24ff4919dc50454594d80 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-5d929b4c79d24ff4919dc50454594d802025-02-03T05:57:43ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/874514874514Combination of Human Leukocyte Antigen and Killer Cell Immunoglobulin-Like Receptor Genetic Background Influences the Onset Age of Hepatocellular Carcinoma in Male Patients with Hepatitis B Virus InfectionNing Pan0Jie Qiu1Hang Sun2Fengqin Miao3Qian Shi4Jinhuan Xu5Wei Jiang6Hui Jin7Wei Xie8Youji He9Jianqiong Zhang10Department of Pathogenic Biology and Immunology, Southeast University Medical School, 87 Dingjiaqiao Road, Nanjing, Jiangsu 210009, ChinaKey Laboratory of Developmental Genes and Human Disease, Ministry of Education, Southeast University, Nanjing, Jiangsu 210009, ChinaKey Laboratory of Developmental Genes and Human Disease, Ministry of Education, Southeast University, Nanjing, Jiangsu 210009, ChinaDepartment of Pathogenic Biology and Immunology, Southeast University Medical School, 87 Dingjiaqiao Road, Nanjing, Jiangsu 210009, ChinaKey Laboratory of Developmental Genes and Human Disease, Ministry of Education, Southeast University, Nanjing, Jiangsu 210009, ChinaKey Laboratory of Developmental Genes and Human Disease, Ministry of Education, Southeast University, Nanjing, Jiangsu 210009, ChinaKey Laboratory of Developmental Genes and Human Disease, Ministry of Education, Southeast University, Nanjing, Jiangsu 210009, ChinaDepartment of Epidemiology, School of Public Health, Southeast University, Nanjing, Jiangsu 210009, ChinaDepartment of Pathogenic Biology and Immunology, Southeast University Medical School, 87 Dingjiaqiao Road, Nanjing, Jiangsu 210009, ChinaDepartment of Pathogenic Biology and Immunology, Southeast University Medical School, 87 Dingjiaqiao Road, Nanjing, Jiangsu 210009, ChinaDepartment of Pathogenic Biology and Immunology, Southeast University Medical School, 87 Dingjiaqiao Road, Nanjing, Jiangsu 210009, ChinaTo investigate whether killer cell immunoglobulin-like receptor (KIR) and human leukocyte antigen (HLA) genetic background could influence the onset age of hepatocellular carcinoma (HCC) in patients with hepatitis B virus (HBV) infection, one hundred and seventy-one males with HBV-related HCC were enrolled. The presence of 12 loci of KIR was detected individually. HLA-A, -B, and -C loci were genotyped with high resolution by a routine sequence-based typing method. The effect of each KIR locus, HLA ligand, and HLA-KIR combination was examined individually by Kaplan-Meier (KM) analysis. Multivariate Cox hazard regression model was also applied. We identified C1C1-KIR2DS2/2DL2 as an independent risk factor for earlier onset age of HCC (median onset age was 44 for C1C1-KIR2DS2/2DL2 positive patients compared to 50 for negative patients, P=0.04 for KM analysis; HR = 1.70, P=0.004 for multivariate Cox model). We conclude that KIR and HLA genetic background can influence the onset age of HCC in male patients with HBV infection. This study may be useful to improve the current HCC surveillance program in HBV-infected patients. Our findings also suggest an important role of natural killer cells (or other KIR-expressing cells) in the progress of HBV-related HCC development.http://dx.doi.org/10.1155/2013/874514 |
| spellingShingle | Ning Pan Jie Qiu Hang Sun Fengqin Miao Qian Shi Jinhuan Xu Wei Jiang Hui Jin Wei Xie Youji He Jianqiong Zhang Combination of Human Leukocyte Antigen and Killer Cell Immunoglobulin-Like Receptor Genetic Background Influences the Onset Age of Hepatocellular Carcinoma in Male Patients with Hepatitis B Virus Infection Clinical and Developmental Immunology |
| title | Combination of Human Leukocyte Antigen and Killer Cell Immunoglobulin-Like Receptor Genetic Background Influences the Onset Age of Hepatocellular Carcinoma in Male Patients with Hepatitis B Virus Infection |
| title_full | Combination of Human Leukocyte Antigen and Killer Cell Immunoglobulin-Like Receptor Genetic Background Influences the Onset Age of Hepatocellular Carcinoma in Male Patients with Hepatitis B Virus Infection |
| title_fullStr | Combination of Human Leukocyte Antigen and Killer Cell Immunoglobulin-Like Receptor Genetic Background Influences the Onset Age of Hepatocellular Carcinoma in Male Patients with Hepatitis B Virus Infection |
| title_full_unstemmed | Combination of Human Leukocyte Antigen and Killer Cell Immunoglobulin-Like Receptor Genetic Background Influences the Onset Age of Hepatocellular Carcinoma in Male Patients with Hepatitis B Virus Infection |
| title_short | Combination of Human Leukocyte Antigen and Killer Cell Immunoglobulin-Like Receptor Genetic Background Influences the Onset Age of Hepatocellular Carcinoma in Male Patients with Hepatitis B Virus Infection |
| title_sort | combination of human leukocyte antigen and killer cell immunoglobulin like receptor genetic background influences the onset age of hepatocellular carcinoma in male patients with hepatitis b virus infection |
| url | http://dx.doi.org/10.1155/2013/874514 |
| work_keys_str_mv | AT ningpan combinationofhumanleukocyteantigenandkillercellimmunoglobulinlikereceptorgeneticbackgroundinfluencestheonsetageofhepatocellularcarcinomainmalepatientswithhepatitisbvirusinfection AT jieqiu combinationofhumanleukocyteantigenandkillercellimmunoglobulinlikereceptorgeneticbackgroundinfluencestheonsetageofhepatocellularcarcinomainmalepatientswithhepatitisbvirusinfection AT hangsun combinationofhumanleukocyteantigenandkillercellimmunoglobulinlikereceptorgeneticbackgroundinfluencestheonsetageofhepatocellularcarcinomainmalepatientswithhepatitisbvirusinfection AT fengqinmiao combinationofhumanleukocyteantigenandkillercellimmunoglobulinlikereceptorgeneticbackgroundinfluencestheonsetageofhepatocellularcarcinomainmalepatientswithhepatitisbvirusinfection AT qianshi combinationofhumanleukocyteantigenandkillercellimmunoglobulinlikereceptorgeneticbackgroundinfluencestheonsetageofhepatocellularcarcinomainmalepatientswithhepatitisbvirusinfection AT jinhuanxu combinationofhumanleukocyteantigenandkillercellimmunoglobulinlikereceptorgeneticbackgroundinfluencestheonsetageofhepatocellularcarcinomainmalepatientswithhepatitisbvirusinfection AT weijiang combinationofhumanleukocyteantigenandkillercellimmunoglobulinlikereceptorgeneticbackgroundinfluencestheonsetageofhepatocellularcarcinomainmalepatientswithhepatitisbvirusinfection AT huijin combinationofhumanleukocyteantigenandkillercellimmunoglobulinlikereceptorgeneticbackgroundinfluencestheonsetageofhepatocellularcarcinomainmalepatientswithhepatitisbvirusinfection AT weixie combinationofhumanleukocyteantigenandkillercellimmunoglobulinlikereceptorgeneticbackgroundinfluencestheonsetageofhepatocellularcarcinomainmalepatientswithhepatitisbvirusinfection AT youjihe combinationofhumanleukocyteantigenandkillercellimmunoglobulinlikereceptorgeneticbackgroundinfluencestheonsetageofhepatocellularcarcinomainmalepatientswithhepatitisbvirusinfection AT jianqiongzhang combinationofhumanleukocyteantigenandkillercellimmunoglobulinlikereceptorgeneticbackgroundinfluencestheonsetageofhepatocellularcarcinomainmalepatientswithhepatitisbvirusinfection |