Umbilical Cord as Prospective Source for Mesenchymal Stem Cell-Based Therapy
The paper presents current evidence on the properties of human umbilical cord-derived mesenchymal stem cells, including origin, proliferative potential, plasticity, stability of karyotype and phenotype, transcriptome, secretome, and immunomodulatory activity. A review of preclinical studies and clin...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/6901286 |
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| _version_ | 1832545306524254208 |
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| author | Irina Arutyunyan Andrey Elchaninov Andrey Makarov Timur Fatkhudinov |
| author_facet | Irina Arutyunyan Andrey Elchaninov Andrey Makarov Timur Fatkhudinov |
| author_sort | Irina Arutyunyan |
| collection | DOAJ |
| description | The paper presents current evidence on the properties of human umbilical cord-derived mesenchymal stem cells, including origin, proliferative potential, plasticity, stability of karyotype and phenotype, transcriptome, secretome, and immunomodulatory activity. A review of preclinical studies and clinical trials using this cell type is performed. Prospects for the use of mesenchymal stem cells, derived from the umbilical cord, in cell transplantation are associated with the need for specialized biobanking and transplant standardization criteria. |
| format | Article |
| id | doaj-art-5d8c9f362d1a40f99a14ba605806bb93 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-5d8c9f362d1a40f99a14ba605806bb932025-02-03T07:26:16ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/69012866901286Umbilical Cord as Prospective Source for Mesenchymal Stem Cell-Based TherapyIrina Arutyunyan0Andrey Elchaninov1Andrey Makarov2Timur Fatkhudinov3Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare of the Russian Federation, No. 4, Oparin Street, Moscow 117997, RussiaPirogov Russian National Research Medical University, Ministry of Healthcare of the Russian Federation, No. 1, Ostrovitianov Street, Moscow 117997, RussiaResearch Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare of the Russian Federation, No. 4, Oparin Street, Moscow 117997, RussiaResearch Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare of the Russian Federation, No. 4, Oparin Street, Moscow 117997, RussiaThe paper presents current evidence on the properties of human umbilical cord-derived mesenchymal stem cells, including origin, proliferative potential, plasticity, stability of karyotype and phenotype, transcriptome, secretome, and immunomodulatory activity. A review of preclinical studies and clinical trials using this cell type is performed. Prospects for the use of mesenchymal stem cells, derived from the umbilical cord, in cell transplantation are associated with the need for specialized biobanking and transplant standardization criteria.http://dx.doi.org/10.1155/2016/6901286 |
| spellingShingle | Irina Arutyunyan Andrey Elchaninov Andrey Makarov Timur Fatkhudinov Umbilical Cord as Prospective Source for Mesenchymal Stem Cell-Based Therapy Stem Cells International |
| title | Umbilical Cord as Prospective Source for Mesenchymal Stem Cell-Based Therapy |
| title_full | Umbilical Cord as Prospective Source for Mesenchymal Stem Cell-Based Therapy |
| title_fullStr | Umbilical Cord as Prospective Source for Mesenchymal Stem Cell-Based Therapy |
| title_full_unstemmed | Umbilical Cord as Prospective Source for Mesenchymal Stem Cell-Based Therapy |
| title_short | Umbilical Cord as Prospective Source for Mesenchymal Stem Cell-Based Therapy |
| title_sort | umbilical cord as prospective source for mesenchymal stem cell based therapy |
| url | http://dx.doi.org/10.1155/2016/6901286 |
| work_keys_str_mv | AT irinaarutyunyan umbilicalcordasprospectivesourceformesenchymalstemcellbasedtherapy AT andreyelchaninov umbilicalcordasprospectivesourceformesenchymalstemcellbasedtherapy AT andreymakarov umbilicalcordasprospectivesourceformesenchymalstemcellbasedtherapy AT timurfatkhudinov umbilicalcordasprospectivesourceformesenchymalstemcellbasedtherapy |