From Inflammation to Prostate Cancer: The Role of Inflammasomes
Inflammation-associated studies entice specific attention due to inflammation’s role in multiple stages of prostate cancer development. However, mechanistic regulation of inflammation inciting prostate cancer remains largely uncharacterized. A focused class of inflammatory regulators known as inflam...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
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| Series: | Advances in Urology |
| Online Access: | http://dx.doi.org/10.1155/2016/3140372 |
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| _version_ | 1832553194877616128 |
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| author | Dev Karan Seema Dubey |
| author_facet | Dev Karan Seema Dubey |
| author_sort | Dev Karan |
| collection | DOAJ |
| description | Inflammation-associated studies entice specific attention due to inflammation’s role in multiple stages of prostate cancer development. However, mechanistic regulation of inflammation inciting prostate cancer remains largely uncharacterized. A focused class of inflammatory regulators known as inflammasomes has recently gained attention in cancer development. Inflammasomes are a multiprotein complex that drives a cascade of proinflammatory cytokines regulating various cellular activities. Inflammasomes activation is linked with infection, stress, or danger signals, which are common events within the prostate gland. In this study, we review the potential of inflammasomes in understanding the role of inflammation in prostate cancer. |
| format | Article |
| id | doaj-art-5d85e34367114492a149dcecbb725240 |
| institution | Kabale University |
| issn | 1687-6369 1687-6377 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Urology |
| spelling | doaj-art-5d85e34367114492a149dcecbb7252402025-02-03T05:55:16ZengWileyAdvances in Urology1687-63691687-63772016-01-01201610.1155/2016/31403723140372From Inflammation to Prostate Cancer: The Role of InflammasomesDev Karan0Seema Dubey1Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, SC 29208, USADepartment of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, SC 29208, USAInflammation-associated studies entice specific attention due to inflammation’s role in multiple stages of prostate cancer development. However, mechanistic regulation of inflammation inciting prostate cancer remains largely uncharacterized. A focused class of inflammatory regulators known as inflammasomes has recently gained attention in cancer development. Inflammasomes are a multiprotein complex that drives a cascade of proinflammatory cytokines regulating various cellular activities. Inflammasomes activation is linked with infection, stress, or danger signals, which are common events within the prostate gland. In this study, we review the potential of inflammasomes in understanding the role of inflammation in prostate cancer.http://dx.doi.org/10.1155/2016/3140372 |
| spellingShingle | Dev Karan Seema Dubey From Inflammation to Prostate Cancer: The Role of Inflammasomes Advances in Urology |
| title | From Inflammation to Prostate Cancer: The Role of Inflammasomes |
| title_full | From Inflammation to Prostate Cancer: The Role of Inflammasomes |
| title_fullStr | From Inflammation to Prostate Cancer: The Role of Inflammasomes |
| title_full_unstemmed | From Inflammation to Prostate Cancer: The Role of Inflammasomes |
| title_short | From Inflammation to Prostate Cancer: The Role of Inflammasomes |
| title_sort | from inflammation to prostate cancer the role of inflammasomes |
| url | http://dx.doi.org/10.1155/2016/3140372 |
| work_keys_str_mv | AT devkaran frominflammationtoprostatecancertheroleofinflammasomes AT seemadubey frominflammationtoprostatecancertheroleofinflammasomes |