Recent advances in the structure and immunomodulatory activity of food-derived glycoprotein complex
Glycoprotein complexes, a kind of structural biomolecules, are characterized by extensive functions, such as immunomodulatory and anti-inflammatory activities. Glycosylation of protein has an important impact on conformational stability and active function of glycoprotein complex. Clarifying the str...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co. Ltd.
2025-11-01
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| Series: | Journal of Future Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772566924000892 |
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| author | Yu Zhong Jiangxiong Zhu Bifen Zhu Hao Yin Danfeng Wang Yun Deng Minyan Zhang Chunrong Zhang |
| author_facet | Yu Zhong Jiangxiong Zhu Bifen Zhu Hao Yin Danfeng Wang Yun Deng Minyan Zhang Chunrong Zhang |
| author_sort | Yu Zhong |
| collection | DOAJ |
| description | Glycoprotein complexes, a kind of structural biomolecules, are characterized by extensive functions, such as immunomodulatory and anti-inflammatory activities. Glycosylation of protein has an important impact on conformational stability and active function of glycoprotein complex. Clarifying the structure of glycoprotein complex is the basis for further exploring its biological activities, and the release of sugar chains is one of the key points in the analysis of glycoprotein structures. Glycoprotein complex can affect the expression of immune-related proteins and factors by activating cell surface receptors, regulating intracellular immune signal transduction, and ultimately play an immunomodulatory role in the body. Meanwhile, the chemical structure and advanced structure of glycoprotein complex can significantly affect the immunomodulatory activity. This review focuses on chemical and advanced structural information of glycoprotein, the regulation mechanism of immunomodulation and the structure-activity relationship, which aims to provide a theoretical basis for the basic research on the immunomodulatory activity of food-derived glycoproteins and the development of related functional products. |
| format | Article |
| id | doaj-art-5d826b8d707a43ebbcb613c38eb45139 |
| institution | Kabale University |
| issn | 2772-5669 |
| language | English |
| publishDate | 2025-11-01 |
| publisher | KeAi Communications Co. Ltd. |
| record_format | Article |
| series | Journal of Future Foods |
| spelling | doaj-art-5d826b8d707a43ebbcb613c38eb451392025-01-30T05:15:13ZengKeAi Communications Co. Ltd.Journal of Future Foods2772-56692025-11-0156542550Recent advances in the structure and immunomodulatory activity of food-derived glycoprotein complexYu Zhong0Jiangxiong Zhu1Bifen Zhu2Hao Yin3Danfeng Wang4Yun Deng5Minyan Zhang6Chunrong Zhang7Department of Food Science & Technology, Shanghai Jiao Tong University, Shanghai 200240, ChinaDepartment of Food Science & Technology, Shanghai Jiao Tong University, Shanghai 200240, ChinaDepartment of Food Science & Technology, Shanghai Jiao Tong University, Shanghai 200240, ChinaDepartment of Food Science & Technology, Shanghai Jiao Tong University, Shanghai 200240, ChinaDepartment of Food Science & Technology, Shanghai Jiao Tong University, Shanghai 200240, ChinaDepartment of Food Science & Technology, Shanghai Jiao Tong University, Shanghai 200240, China; Corresponding author at: Department of Food Science & Technology, Shanghai Jiao Tong University, Shanghai 200240, China.Inspection and Testing Institute of Eryuan County, Dali 671299, ChinaInspection and Testing Institute of Eryuan County, Dali 671299, ChinaGlycoprotein complexes, a kind of structural biomolecules, are characterized by extensive functions, such as immunomodulatory and anti-inflammatory activities. Glycosylation of protein has an important impact on conformational stability and active function of glycoprotein complex. Clarifying the structure of glycoprotein complex is the basis for further exploring its biological activities, and the release of sugar chains is one of the key points in the analysis of glycoprotein structures. Glycoprotein complex can affect the expression of immune-related proteins and factors by activating cell surface receptors, regulating intracellular immune signal transduction, and ultimately play an immunomodulatory role in the body. Meanwhile, the chemical structure and advanced structure of glycoprotein complex can significantly affect the immunomodulatory activity. This review focuses on chemical and advanced structural information of glycoprotein, the regulation mechanism of immunomodulation and the structure-activity relationship, which aims to provide a theoretical basis for the basic research on the immunomodulatory activity of food-derived glycoproteins and the development of related functional products.http://www.sciencedirect.com/science/article/pii/S2772566924000892Glycoprotein complexStructureImmunomodulatory activityStructure-activity relationship |
| spellingShingle | Yu Zhong Jiangxiong Zhu Bifen Zhu Hao Yin Danfeng Wang Yun Deng Minyan Zhang Chunrong Zhang Recent advances in the structure and immunomodulatory activity of food-derived glycoprotein complex Journal of Future Foods Glycoprotein complex Structure Immunomodulatory activity Structure-activity relationship |
| title | Recent advances in the structure and immunomodulatory activity of food-derived glycoprotein complex |
| title_full | Recent advances in the structure and immunomodulatory activity of food-derived glycoprotein complex |
| title_fullStr | Recent advances in the structure and immunomodulatory activity of food-derived glycoprotein complex |
| title_full_unstemmed | Recent advances in the structure and immunomodulatory activity of food-derived glycoprotein complex |
| title_short | Recent advances in the structure and immunomodulatory activity of food-derived glycoprotein complex |
| title_sort | recent advances in the structure and immunomodulatory activity of food derived glycoprotein complex |
| topic | Glycoprotein complex Structure Immunomodulatory activity Structure-activity relationship |
| url | http://www.sciencedirect.com/science/article/pii/S2772566924000892 |
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