The Alterations in the Brain Corresponding to Low Back Pain: Recent Insights and Advances
Low back pain (LBP) is a leading cause of global disabilities. Numerous molecular, cellular, and anatomical factors are implicated in LBP. Current issues regarding neurologic alterations in LBP have focused on the reorganization of peripheral nerve and spinal cord, but neural mechanisms of exactly w...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2024/5599046 |
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| author | Xuyang Li Fancheng Meng Wenye Huang Yue Cui Fanbo Meng Shengxi Wu Hui Xu |
| author_facet | Xuyang Li Fancheng Meng Wenye Huang Yue Cui Fanbo Meng Shengxi Wu Hui Xu |
| author_sort | Xuyang Li |
| collection | DOAJ |
| description | Low back pain (LBP) is a leading cause of global disabilities. Numerous molecular, cellular, and anatomical factors are implicated in LBP. Current issues regarding neurologic alterations in LBP have focused on the reorganization of peripheral nerve and spinal cord, but neural mechanisms of exactly what LBP impacts on the brain required further researches. Based on existing clinical studies that chronic pain problems were accompanying alterations in brain structures and functions, researchers proposed logical conjectures that similar alterations occur in LBP patients as well. With recent extensive studies carried out using noninvasive neuroimaging technique, increasing number of abnormalities and alterations has been identified. Here, we reviewed brain alterations including white matters, grey matters, and neural circuits between brain areas, which are involved in chronic LBP. Moreover, brain structural and functional connectivity abnormalities are correlated to the happening and transition of LBP. The negative emotions related to back pain indicate possible alterations in emotional brain regions. Thus, the aim of this review is to summarize current findings on the alterations corresponding to LBP in the brain. It will not only further our understanding of etiology of LBP and understanding of negative emotions accompanying with back pain but also provide ideas and basis for new accesses to the diagnosis, treatment, and rehabilitation afterward based on integral medicine. |
| format | Article |
| id | doaj-art-5d7e3d73e00e40859d5fdb64ce136cdb |
| institution | Kabale University |
| issn | 1687-5443 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-5d7e3d73e00e40859d5fdb64ce136cdb2025-02-03T07:23:24ZengWileyNeural Plasticity1687-54432024-01-01202410.1155/2024/5599046The Alterations in the Brain Corresponding to Low Back Pain: Recent Insights and AdvancesXuyang Li0Fancheng Meng1Wenye Huang2Yue Cui3Fanbo Meng4Shengxi Wu5Hui Xu6Department of Neurobiology and Collaborative Innovation Center for Brain ScienceDepartment of Neurobiology and Collaborative Innovation Center for Brain ScienceDepartment of Neurobiology and Collaborative Innovation Center for Brain ScienceDepartment of Neurobiology and Collaborative Innovation Center for Brain ScienceDepartment of Neurobiology and Collaborative Innovation Center for Brain ScienceDepartment of Neurobiology and Collaborative Innovation Center for Brain ScienceDepartment of Neurobiology and Collaborative Innovation Center for Brain ScienceLow back pain (LBP) is a leading cause of global disabilities. Numerous molecular, cellular, and anatomical factors are implicated in LBP. Current issues regarding neurologic alterations in LBP have focused on the reorganization of peripheral nerve and spinal cord, but neural mechanisms of exactly what LBP impacts on the brain required further researches. Based on existing clinical studies that chronic pain problems were accompanying alterations in brain structures and functions, researchers proposed logical conjectures that similar alterations occur in LBP patients as well. With recent extensive studies carried out using noninvasive neuroimaging technique, increasing number of abnormalities and alterations has been identified. Here, we reviewed brain alterations including white matters, grey matters, and neural circuits between brain areas, which are involved in chronic LBP. Moreover, brain structural and functional connectivity abnormalities are correlated to the happening and transition of LBP. The negative emotions related to back pain indicate possible alterations in emotional brain regions. Thus, the aim of this review is to summarize current findings on the alterations corresponding to LBP in the brain. It will not only further our understanding of etiology of LBP and understanding of negative emotions accompanying with back pain but also provide ideas and basis for new accesses to the diagnosis, treatment, and rehabilitation afterward based on integral medicine.http://dx.doi.org/10.1155/2024/5599046 |
| spellingShingle | Xuyang Li Fancheng Meng Wenye Huang Yue Cui Fanbo Meng Shengxi Wu Hui Xu The Alterations in the Brain Corresponding to Low Back Pain: Recent Insights and Advances Neural Plasticity |
| title | The Alterations in the Brain Corresponding to Low Back Pain: Recent Insights and Advances |
| title_full | The Alterations in the Brain Corresponding to Low Back Pain: Recent Insights and Advances |
| title_fullStr | The Alterations in the Brain Corresponding to Low Back Pain: Recent Insights and Advances |
| title_full_unstemmed | The Alterations in the Brain Corresponding to Low Back Pain: Recent Insights and Advances |
| title_short | The Alterations in the Brain Corresponding to Low Back Pain: Recent Insights and Advances |
| title_sort | alterations in the brain corresponding to low back pain recent insights and advances |
| url | http://dx.doi.org/10.1155/2024/5599046 |
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