Impact of Underweight after Treatment on Prognosis of Advanced-Stage Ovarian Cancer
This study aimed to investigate the impact of underweight status on the prognosis of advanced-stage ovarian cancer. A total of 360 patients with stage III-IV epithelial ovarian cancer were enrolled and divided into three groups by body mass indexes (BMIs): underweight (BMI < 18.5 kg/m2); normal w...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2014/349546 |
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| author | Se Ik Kim Hee Seung Kim Tae Hun Kim Dong Hoon Suh Kidong Kim Jae Hong No Hyun Hoon Chung Yong Beom Kim Yong Sang Song |
| author_facet | Se Ik Kim Hee Seung Kim Tae Hun Kim Dong Hoon Suh Kidong Kim Jae Hong No Hyun Hoon Chung Yong Beom Kim Yong Sang Song |
| author_sort | Se Ik Kim |
| collection | DOAJ |
| description | This study aimed to investigate the impact of underweight status on the prognosis of advanced-stage ovarian cancer. A total of 360 patients with stage III-IV epithelial ovarian cancer were enrolled and divided into three groups by body mass indexes (BMIs): underweight (BMI < 18.5 kg/m2); normal weight to overweight (18.5 kg/m2 BMI < 27.5 kg/m2); obesity (BMI ≥ 27.5 kg/m2). Progression-free survival (PFS), overall survival (OS), CA-125, and neutrophil to lymphocyte ratio (NLR) as a marker reflecting host inflammation and immunity were compared among the three groups according to the three treatment times: at diagnosis; after surgery; and after treatment. Only underweight status after treatment was associated with poor OS in comparison with normal weight to overweight or obesity (mean value, 44.9 versus 78.8 or 67.4 months; P=0.05); it was also an unfavorable factor for OS (adjusted HR, 2.29; 95% CI, 1.08–4.85). Furthermore, NLR was higher in patients with underweight than in those with obesity after treatment (median value, 2.15 versus 1.47; P=0.03), in spite of no difference in CA-125 among the three groups at the three treatment times. In conclusion, underweight status after treatment may be a poor prognostic factor in patients with advanced-stage ovarian cancer, which accompanies increased host inflammation and decreased immunity. |
| format | Article |
| id | doaj-art-5d51a089788e4023bc4d4a4b9b1c30df |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-5d51a089788e4023bc4d4a4b9b1c30df2025-02-03T06:42:09ZengWileyJournal of Immunology Research2314-88612314-71562014-01-01201410.1155/2014/349546349546Impact of Underweight after Treatment on Prognosis of Advanced-Stage Ovarian CancerSe Ik Kim0Hee Seung Kim1Tae Hun Kim2Dong Hoon Suh3Kidong Kim4Jae Hong No5Hyun Hoon Chung6Yong Beom Kim7Yong Sang Song8Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul 110-744, Republic of KoreaDepartment of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul 110-744, Republic of KoreaDepartment of Obstetrics and Gynecology, Korean Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul 139-706, Republic of KoreaDepartment of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam 463-707, Republic of KoreaDepartment of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam 463-707, Republic of KoreaDepartment of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam 463-707, Republic of KoreaDepartment of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul 110-744, Republic of KoreaDepartment of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam 463-707, Republic of KoreaDepartment of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul 110-744, Republic of KoreaThis study aimed to investigate the impact of underweight status on the prognosis of advanced-stage ovarian cancer. A total of 360 patients with stage III-IV epithelial ovarian cancer were enrolled and divided into three groups by body mass indexes (BMIs): underweight (BMI < 18.5 kg/m2); normal weight to overweight (18.5 kg/m2 BMI < 27.5 kg/m2); obesity (BMI ≥ 27.5 kg/m2). Progression-free survival (PFS), overall survival (OS), CA-125, and neutrophil to lymphocyte ratio (NLR) as a marker reflecting host inflammation and immunity were compared among the three groups according to the three treatment times: at diagnosis; after surgery; and after treatment. Only underweight status after treatment was associated with poor OS in comparison with normal weight to overweight or obesity (mean value, 44.9 versus 78.8 or 67.4 months; P=0.05); it was also an unfavorable factor for OS (adjusted HR, 2.29; 95% CI, 1.08–4.85). Furthermore, NLR was higher in patients with underweight than in those with obesity after treatment (median value, 2.15 versus 1.47; P=0.03), in spite of no difference in CA-125 among the three groups at the three treatment times. In conclusion, underweight status after treatment may be a poor prognostic factor in patients with advanced-stage ovarian cancer, which accompanies increased host inflammation and decreased immunity.http://dx.doi.org/10.1155/2014/349546 |
| spellingShingle | Se Ik Kim Hee Seung Kim Tae Hun Kim Dong Hoon Suh Kidong Kim Jae Hong No Hyun Hoon Chung Yong Beom Kim Yong Sang Song Impact of Underweight after Treatment on Prognosis of Advanced-Stage Ovarian Cancer Journal of Immunology Research |
| title | Impact of Underweight after Treatment on Prognosis of Advanced-Stage Ovarian Cancer |
| title_full | Impact of Underweight after Treatment on Prognosis of Advanced-Stage Ovarian Cancer |
| title_fullStr | Impact of Underweight after Treatment on Prognosis of Advanced-Stage Ovarian Cancer |
| title_full_unstemmed | Impact of Underweight after Treatment on Prognosis of Advanced-Stage Ovarian Cancer |
| title_short | Impact of Underweight after Treatment on Prognosis of Advanced-Stage Ovarian Cancer |
| title_sort | impact of underweight after treatment on prognosis of advanced stage ovarian cancer |
| url | http://dx.doi.org/10.1155/2014/349546 |
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