Curcumin dietary supplementation enhances serum carbohydrate-degrading enzyme activities in buffaloes
Curcumin, the major bioactive compound found in turmeric (Curcuma longa) is a subject of intensive research, due to its multiple bioactivities. Previous studies have investigated metabolic effects of curcumin in humans or established animal research models such as mice, but studies with farm animals...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Current Research in Biotechnology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S259026282500005X |
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| author | Maima Matin Natalia Ksepka Kamil Wysocki Michel-Edwar Mickael Alpana Pande Jarosław Olav Horbańczuk Artur Jóźwik Olga Adamska Artur Stolarczyk Laszlo Barna Iantovics Yordanka Ilieva Pencho Penchev Atanas G. Atanasov |
| author_facet | Maima Matin Natalia Ksepka Kamil Wysocki Michel-Edwar Mickael Alpana Pande Jarosław Olav Horbańczuk Artur Jóźwik Olga Adamska Artur Stolarczyk Laszlo Barna Iantovics Yordanka Ilieva Pencho Penchev Atanas G. Atanasov |
| author_sort | Maima Matin |
| collection | DOAJ |
| description | Curcumin, the major bioactive compound found in turmeric (Curcuma longa) is a subject of intensive research, due to its multiple bioactivities. Previous studies have investigated metabolic effects of curcumin in humans or established animal research models such as mice, but studies with farm animals have been scarce. In this work, we aimed to study the effects of curcumin supplementation in Bulgarian Murrah buffaloes (Bubalus bubalis), on the serum activities of seven important carbohydrate-metabolizing enzymes, β-glucuronidase, α-galactosidase, α-glucosidase, β-glucosidase, β-galactosidase, N-acetyl-hexosaminidase, and mannosidase. Curcumin was supplemented at a dose of 50 g per animal, per day, and serum activities of the studied enzymes were determined at the start (day 0), middle (day 14), and end (day 28) of the supplementation period. A tendency for increased activity of all studied enzymes was observed upon supplementation with curcumin, with the activity levels of five of the enzymes displaying statistically significant upregulation at day 28 (β-glucuronidase, α-galactosidase, β-galactosidase, N-acetyl-hexosaminidase, and mannosidase). These upregulated activities are in general indicative of increased carbohydrates turnover and detoxification processes, and might provide clues for a better understanding of the mechanisms of action of curcumin in vivo, as well as for novel approaches to rationally impact animal or human health and wellbeing through targeted supplementation. |
| format | Article |
| id | doaj-art-5d500d39d9eb495c86c7f13b5ec2c6ab |
| institution | Kabale University |
| issn | 2590-2628 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Biotechnology |
| spelling | doaj-art-5d500d39d9eb495c86c7f13b5ec2c6ab2025-02-06T05:12:45ZengElsevierCurrent Research in Biotechnology2590-26282025-01-019100276Curcumin dietary supplementation enhances serum carbohydrate-degrading enzyme activities in buffaloesMaima Matin0Natalia Ksepka1Kamil Wysocki2Michel-Edwar Mickael3Alpana Pande4Jarosław Olav Horbańczuk5Artur Jóźwik6Olga Adamska7Artur Stolarczyk8Laszlo Barna Iantovics9Yordanka Ilieva10Pencho Penchev11Atanas G. Atanasov12Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, Jastrzebiec, 05-552 Magdalenka, PolandInstitute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, Jastrzebiec, 05-552 Magdalenka, PolandInstitute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, Jastrzebiec, 05-552 Magdalenka, PolandInstitute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, Jastrzebiec, 05-552 Magdalenka, PolandSabinsa Corporation, East Windsor, NJ, USAInstitute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, Jastrzebiec, 05-552 Magdalenka, PolandInstitute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, Jastrzebiec, 05-552 Magdalenka, PolandFaculty of Medicine, Cardinal Stefan Wyszynski University, 01-938 Warsaw, PolandOrthopaedic and Rehabilitation Department, Medical University of Warsaw, 02-091 Warsaw, PolandDepartment of Electrical Engineering and Information Technology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș, Gh. Marinescu, 38, 540142, Târgu Mureș, RomaniaAgricultural Academy, Sofia, Agricultural Institute – Shumen, 3 Simeon Veliki Blvd, Shumen 9700, BulgariaAgricultural Academy, Sofia, Agricultural Institute – Shumen, 3 Simeon Veliki Blvd, Shumen 9700, BulgariaInstitute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, Jastrzebiec, 05-552 Magdalenka, Poland; Ludwig Boltzmann Institute Digital Health and Patient Safety, Medical University of Vienna, Spitalgasse 23, 1090 Vienna, Austria; Corresponding author at: Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, ul. Postepu 36A, Jastrzębiec, 05-552 Magdalenka, Poland.Curcumin, the major bioactive compound found in turmeric (Curcuma longa) is a subject of intensive research, due to its multiple bioactivities. Previous studies have investigated metabolic effects of curcumin in humans or established animal research models such as mice, but studies with farm animals have been scarce. In this work, we aimed to study the effects of curcumin supplementation in Bulgarian Murrah buffaloes (Bubalus bubalis), on the serum activities of seven important carbohydrate-metabolizing enzymes, β-glucuronidase, α-galactosidase, α-glucosidase, β-glucosidase, β-galactosidase, N-acetyl-hexosaminidase, and mannosidase. Curcumin was supplemented at a dose of 50 g per animal, per day, and serum activities of the studied enzymes were determined at the start (day 0), middle (day 14), and end (day 28) of the supplementation period. A tendency for increased activity of all studied enzymes was observed upon supplementation with curcumin, with the activity levels of five of the enzymes displaying statistically significant upregulation at day 28 (β-glucuronidase, α-galactosidase, β-galactosidase, N-acetyl-hexosaminidase, and mannosidase). These upregulated activities are in general indicative of increased carbohydrates turnover and detoxification processes, and might provide clues for a better understanding of the mechanisms of action of curcumin in vivo, as well as for novel approaches to rationally impact animal or human health and wellbeing through targeted supplementation.http://www.sciencedirect.com/science/article/pii/S259026282500005XCurcuminMurrah buffaloesTurmericβ-glucuronidaseβ-galactosidaseCarbohydrate-degrading enzymes |
| spellingShingle | Maima Matin Natalia Ksepka Kamil Wysocki Michel-Edwar Mickael Alpana Pande Jarosław Olav Horbańczuk Artur Jóźwik Olga Adamska Artur Stolarczyk Laszlo Barna Iantovics Yordanka Ilieva Pencho Penchev Atanas G. Atanasov Curcumin dietary supplementation enhances serum carbohydrate-degrading enzyme activities in buffaloes Current Research in Biotechnology Curcumin Murrah buffaloes Turmeric β-glucuronidase β-galactosidase Carbohydrate-degrading enzymes |
| title | Curcumin dietary supplementation enhances serum carbohydrate-degrading enzyme activities in buffaloes |
| title_full | Curcumin dietary supplementation enhances serum carbohydrate-degrading enzyme activities in buffaloes |
| title_fullStr | Curcumin dietary supplementation enhances serum carbohydrate-degrading enzyme activities in buffaloes |
| title_full_unstemmed | Curcumin dietary supplementation enhances serum carbohydrate-degrading enzyme activities in buffaloes |
| title_short | Curcumin dietary supplementation enhances serum carbohydrate-degrading enzyme activities in buffaloes |
| title_sort | curcumin dietary supplementation enhances serum carbohydrate degrading enzyme activities in buffaloes |
| topic | Curcumin Murrah buffaloes Turmeric β-glucuronidase β-galactosidase Carbohydrate-degrading enzymes |
| url | http://www.sciencedirect.com/science/article/pii/S259026282500005X |
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