Alteration of Energy Substrates and ROS Production in Diabetic Cardiomyopathy
Diabetic cardiomyopathy is initiated by alterations in energy substrates. Despite excess of plasma glucose and lipids, the diabetic heart almost exclusively depends on fatty acid degradation. Glycolytic enzymes and transporters are impaired by fatty acid metabolism, leading to accumulation of glucos...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/461967 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832564476054863872 |
|---|---|
| author | O. Lorenzo E. Ramírez B. Picatoste J. Egido J. Tuñón |
| author_facet | O. Lorenzo E. Ramírez B. Picatoste J. Egido J. Tuñón |
| author_sort | O. Lorenzo |
| collection | DOAJ |
| description | Diabetic cardiomyopathy is initiated by alterations in energy substrates. Despite excess of plasma glucose and lipids, the diabetic heart almost exclusively depends on fatty acid degradation. Glycolytic enzymes and transporters are impaired by fatty acid metabolism, leading to accumulation of glucose derivatives. However, fatty acid oxidation yields lower ATP production per mole of oxygen than glucose, causing mitochondrial uncoupling and decreased energy efficiency. In addition, the oxidation of fatty acids can saturate and cause their deposition in the cytosol, where they deviate to induce toxic metabolites or gene expression by nuclear-receptor interaction. Hyperglycemia, the fatty acid oxidation pathway, and the cytosolic storage of fatty acid and glucose/fatty acid derivatives are major inducers of reactive oxygen species. However, the presence of these species can be essential for physiological responses in the diabetic myocardium. |
| format | Article |
| id | doaj-art-5d4ad59f3e274a88b1bf3f89ff626ca1 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-5d4ad59f3e274a88b1bf3f89ff626ca12025-02-03T01:10:59ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/461967461967Alteration of Energy Substrates and ROS Production in Diabetic CardiomyopathyO. Lorenzo0E. Ramírez1B. Picatoste2J. Egido3J. Tuñón4IIS-Fundación Jiménez Díaz, Autónoma University, Avenue Reyes Católicos 2, 28040 Madrid, SpainIIS-Fundación Jiménez Díaz, Autónoma University, Avenue Reyes Católicos 2, 28040 Madrid, SpainIIS-Fundación Jiménez Díaz, Autónoma University, Avenue Reyes Católicos 2, 28040 Madrid, SpainIIS-Fundación Jiménez Díaz, Autónoma University, Avenue Reyes Católicos 2, 28040 Madrid, SpainIIS-Fundación Jiménez Díaz, Autónoma University, Avenue Reyes Católicos 2, 28040 Madrid, SpainDiabetic cardiomyopathy is initiated by alterations in energy substrates. Despite excess of plasma glucose and lipids, the diabetic heart almost exclusively depends on fatty acid degradation. Glycolytic enzymes and transporters are impaired by fatty acid metabolism, leading to accumulation of glucose derivatives. However, fatty acid oxidation yields lower ATP production per mole of oxygen than glucose, causing mitochondrial uncoupling and decreased energy efficiency. In addition, the oxidation of fatty acids can saturate and cause their deposition in the cytosol, where they deviate to induce toxic metabolites or gene expression by nuclear-receptor interaction. Hyperglycemia, the fatty acid oxidation pathway, and the cytosolic storage of fatty acid and glucose/fatty acid derivatives are major inducers of reactive oxygen species. However, the presence of these species can be essential for physiological responses in the diabetic myocardium.http://dx.doi.org/10.1155/2013/461967 |
| spellingShingle | O. Lorenzo E. Ramírez B. Picatoste J. Egido J. Tuñón Alteration of Energy Substrates and ROS Production in Diabetic Cardiomyopathy Mediators of Inflammation |
| title | Alteration of Energy Substrates and ROS Production in Diabetic Cardiomyopathy |
| title_full | Alteration of Energy Substrates and ROS Production in Diabetic Cardiomyopathy |
| title_fullStr | Alteration of Energy Substrates and ROS Production in Diabetic Cardiomyopathy |
| title_full_unstemmed | Alteration of Energy Substrates and ROS Production in Diabetic Cardiomyopathy |
| title_short | Alteration of Energy Substrates and ROS Production in Diabetic Cardiomyopathy |
| title_sort | alteration of energy substrates and ros production in diabetic cardiomyopathy |
| url | http://dx.doi.org/10.1155/2013/461967 |
| work_keys_str_mv | AT olorenzo alterationofenergysubstratesandrosproductionindiabeticcardiomyopathy AT eramirez alterationofenergysubstratesandrosproductionindiabeticcardiomyopathy AT bpicatoste alterationofenergysubstratesandrosproductionindiabeticcardiomyopathy AT jegido alterationofenergysubstratesandrosproductionindiabeticcardiomyopathy AT jtunon alterationofenergysubstratesandrosproductionindiabeticcardiomyopathy |