Bile Nephropathy in Flucloxacillin-Induced Cholestatic Liver Dysfunction
Kidney injury in the context of cholestatic liver dysfunction is not uncommon; this has been historically referred to as cholemic nephrosis implying a direct deleterious renal effect of cholemia. However, scepticism about the exact role that bile and its constituents play in this injury has led to t...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2016/4162674 |
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| author | Basil Alnasrallah John F. Collins L. Jonathan Zwi |
| author_facet | Basil Alnasrallah John F. Collins L. Jonathan Zwi |
| author_sort | Basil Alnasrallah |
| collection | DOAJ |
| description | Kidney injury in the context of cholestatic liver dysfunction is not uncommon; this has been historically referred to as cholemic nephrosis implying a direct deleterious renal effect of cholemia. However, scepticism about the exact role that bile and its constituents play in this injury has led to the disappearance of the term. We describe a case of severe AKI due to bile nephropathy with bile casts in flucloxacillin-induced liver dysfunction. We also discuss the recent literature reviving the concept of bile nephropathy. |
| format | Article |
| id | doaj-art-5d4860cca2004ee9adfc58a174931efa |
| institution | Kabale University |
| issn | 2090-6641 2090-665X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Nephrology |
| spelling | doaj-art-5d4860cca2004ee9adfc58a174931efa2025-02-03T01:09:32ZengWileyCase Reports in Nephrology2090-66412090-665X2016-01-01201610.1155/2016/41626744162674Bile Nephropathy in Flucloxacillin-Induced Cholestatic Liver DysfunctionBasil Alnasrallah0John F. Collins1L. Jonathan Zwi2Department of Nephrology, Auckland City Hospital, Auckland 1023, New ZealandDepartment of Nephrology, Auckland City Hospital, Auckland 1023, New ZealandDepartment of Pathology, Auckland City Hospital, Auckland 1023, New ZealandKidney injury in the context of cholestatic liver dysfunction is not uncommon; this has been historically referred to as cholemic nephrosis implying a direct deleterious renal effect of cholemia. However, scepticism about the exact role that bile and its constituents play in this injury has led to the disappearance of the term. We describe a case of severe AKI due to bile nephropathy with bile casts in flucloxacillin-induced liver dysfunction. We also discuss the recent literature reviving the concept of bile nephropathy.http://dx.doi.org/10.1155/2016/4162674 |
| spellingShingle | Basil Alnasrallah John F. Collins L. Jonathan Zwi Bile Nephropathy in Flucloxacillin-Induced Cholestatic Liver Dysfunction Case Reports in Nephrology |
| title | Bile Nephropathy in Flucloxacillin-Induced Cholestatic Liver Dysfunction |
| title_full | Bile Nephropathy in Flucloxacillin-Induced Cholestatic Liver Dysfunction |
| title_fullStr | Bile Nephropathy in Flucloxacillin-Induced Cholestatic Liver Dysfunction |
| title_full_unstemmed | Bile Nephropathy in Flucloxacillin-Induced Cholestatic Liver Dysfunction |
| title_short | Bile Nephropathy in Flucloxacillin-Induced Cholestatic Liver Dysfunction |
| title_sort | bile nephropathy in flucloxacillin induced cholestatic liver dysfunction |
| url | http://dx.doi.org/10.1155/2016/4162674 |
| work_keys_str_mv | AT basilalnasrallah bilenephropathyinflucloxacillininducedcholestaticliverdysfunction AT johnfcollins bilenephropathyinflucloxacillininducedcholestaticliverdysfunction AT ljonathanzwi bilenephropathyinflucloxacillininducedcholestaticliverdysfunction |