Pancytopenia in a 70-Year-Old African-American Male: An Unusual Presentation of a Rare Disease
Hairy cell leukemia is a rare lymphoid neoplasm arising from mature B-lymphocytes. Clinically, the disease presents with splenomegaly and abdominal discomfort, frequent infections, fatigue and bleeding because of related cytopenias. Bone marrow biopsy is essential for diagnosis. Below we describe a...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2014/354810 |
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| author | Aibek E. Mirrakhimov Alaa M. Ali Aram Barbaryan Nwabundo Anusim Raya Saba Shawn G. Kwatra Nasir Hussain Teresita Zdunek Alan D. Gilman |
| author_facet | Aibek E. Mirrakhimov Alaa M. Ali Aram Barbaryan Nwabundo Anusim Raya Saba Shawn G. Kwatra Nasir Hussain Teresita Zdunek Alan D. Gilman |
| author_sort | Aibek E. Mirrakhimov |
| collection | DOAJ |
| description | Hairy cell leukemia is a rare lymphoid neoplasm arising from mature B-lymphocytes. Clinically, the disease presents with splenomegaly and abdominal discomfort, frequent infections, fatigue and bleeding because of related cytopenias. Bone marrow biopsy is essential for diagnosis. Below we describe a case of a 70-year-old African-American male who presented to our hematology clinic complaining of fatigue. Clinical exam and computed tomography imaging did not reveal splenic enlargement. Blood work-up revealed pancytopenia and bone marrow was diagnostic for hairy cell leukemia.The patient was started on cladribine, with gradual improvement of his symptoms and blood count abnormalities. Therefore, it is essential to keep hairy cell leukemia in the differential of pancytopenia even in the absence of a splenomegaly. |
| format | Article |
| id | doaj-art-5d40e93928db4119ba5d0b67d2ac406d |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-5d40e93928db4119ba5d0b67d2ac406d2025-02-03T05:57:35ZengWileyCase Reports in Hematology2090-65602090-65792014-01-01201410.1155/2014/354810354810Pancytopenia in a 70-Year-Old African-American Male: An Unusual Presentation of a Rare DiseaseAibek E. Mirrakhimov0Alaa M. Ali1Aram Barbaryan2Nwabundo Anusim3Raya Saba4Shawn G. Kwatra5Nasir Hussain6Teresita Zdunek7Alan D. Gilman8Department of Internal Medicine, Saint Joseph Hospital, 2900 North Lake Shore Drive, Chicago, IL 60657, USADepartment of Internal Medicine, Saint Joseph Hospital, 2900 North Lake Shore Drive, Chicago, IL 60657, USADepartment of Internal Medicine, Saint Joseph Hospital, 2900 North Lake Shore Drive, Chicago, IL 60657, USADepartment of Internal Medicine, Saint Joseph Hospital, 2900 North Lake Shore Drive, Chicago, IL 60657, USADepartment of Internal Medicine, Saint Joseph Hospital, 2900 North Lake Shore Drive, Chicago, IL 60657, USADepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USADepartment of Internal Medicine, Saint Joseph Hospital, 2900 North Lake Shore Drive, Chicago, IL 60657, USADepartment of Pathology, Saint Joseph Hospital, 2900 North Lake Shore Drive, Chicago, IL 60657, USADivision of Hematology and Oncology, Saint Joseph Hospital, 2900 North Lake Shore Drive, Chicago, IL 60657, USAHairy cell leukemia is a rare lymphoid neoplasm arising from mature B-lymphocytes. Clinically, the disease presents with splenomegaly and abdominal discomfort, frequent infections, fatigue and bleeding because of related cytopenias. Bone marrow biopsy is essential for diagnosis. Below we describe a case of a 70-year-old African-American male who presented to our hematology clinic complaining of fatigue. Clinical exam and computed tomography imaging did not reveal splenic enlargement. Blood work-up revealed pancytopenia and bone marrow was diagnostic for hairy cell leukemia.The patient was started on cladribine, with gradual improvement of his symptoms and blood count abnormalities. Therefore, it is essential to keep hairy cell leukemia in the differential of pancytopenia even in the absence of a splenomegaly.http://dx.doi.org/10.1155/2014/354810 |
| spellingShingle | Aibek E. Mirrakhimov Alaa M. Ali Aram Barbaryan Nwabundo Anusim Raya Saba Shawn G. Kwatra Nasir Hussain Teresita Zdunek Alan D. Gilman Pancytopenia in a 70-Year-Old African-American Male: An Unusual Presentation of a Rare Disease Case Reports in Hematology |
| title | Pancytopenia in a 70-Year-Old African-American Male: An Unusual Presentation of a Rare Disease |
| title_full | Pancytopenia in a 70-Year-Old African-American Male: An Unusual Presentation of a Rare Disease |
| title_fullStr | Pancytopenia in a 70-Year-Old African-American Male: An Unusual Presentation of a Rare Disease |
| title_full_unstemmed | Pancytopenia in a 70-Year-Old African-American Male: An Unusual Presentation of a Rare Disease |
| title_short | Pancytopenia in a 70-Year-Old African-American Male: An Unusual Presentation of a Rare Disease |
| title_sort | pancytopenia in a 70 year old african american male an unusual presentation of a rare disease |
| url | http://dx.doi.org/10.1155/2014/354810 |
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