Adalimumab: Another Medication Related to Osteonecrosis of the Jaws?
Objective. The acronym MRONJ has been created in order to identify “Medication-Related Osteonecrosis of the Jaw,” observed after the use of Bisphosphonates, RANK ligand inhibitor, and antiangiogenic medications. Only a case of osteonecrosis of the jaw in a Chron’s disease patient following a course...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2016/2856926 |
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| _version_ | 1832567793205116928 |
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| author | Andrea Cassoni Umberto Romeo Valentina Terenzi Marco Della Monaca Oriana Rajabtork Zadeh Ingrid Raponi Maria Teresa Fadda Antonella Polimeni Valentino Valentini |
| author_facet | Andrea Cassoni Umberto Romeo Valentina Terenzi Marco Della Monaca Oriana Rajabtork Zadeh Ingrid Raponi Maria Teresa Fadda Antonella Polimeni Valentino Valentini |
| author_sort | Andrea Cassoni |
| collection | DOAJ |
| description | Objective. The acronym MRONJ has been created in order to identify “Medication-Related Osteonecrosis of the Jaw,” observed after the use of Bisphosphonates, RANK ligand inhibitor, and antiangiogenic medications. Only a case of osteonecrosis of the jaw in a Chron’s disease patient following a course of Bisphosphonate and Adalimumab therapy has been recently described, so that it has been supposed that also this medication could promote manifestation of osteonecrosis. Clinical Case. On August, 2014, a 63-year-old female with a history of idiopathic arthritis treated with medical treatment with Adalimumab from 2010 to 2013 presented referring pain in the right mandible. Results. This patient presented with nonexposed osteonecrosis of the jaw after placement, on September, 2010, of four titanium fixtures in the mandible. Conclusions. The authors suggest that the biologic therapy with an anti-TNF-α antibody might promote the manifestation of osteonecrosis and compromise oral healing capacity of the bone. |
| format | Article |
| id | doaj-art-5d3f247acd8041baa7312eadec0207a4 |
| institution | Kabale University |
| issn | 2090-6447 2090-6455 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Dentistry |
| spelling | doaj-art-5d3f247acd8041baa7312eadec0207a42025-02-03T01:00:28ZengWileyCase Reports in Dentistry2090-64472090-64552016-01-01201610.1155/2016/28569262856926Adalimumab: Another Medication Related to Osteonecrosis of the Jaws?Andrea Cassoni0Umberto Romeo1Valentina Terenzi2Marco Della Monaca3Oriana Rajabtork Zadeh4Ingrid Raponi5Maria Teresa Fadda6Antonella Polimeni7Valentino Valentini8Odontostomatological Science and Maxillo facial Surgery Department, “Sapienza” University of Rome, 00161 Rome, ItalyOdontostomatological Science and Maxillo facial Surgery Department, “Sapienza” University of Rome, 00161 Rome, ItalyOdontostomatological Science and Maxillo facial Surgery Department, “Sapienza” University of Rome, 00161 Rome, ItalyOdontostomatological Science and Maxillo facial Surgery Department, “Sapienza” University of Rome, 00161 Rome, ItalyOdontostomatological Science and Maxillo facial Surgery Department, “Sapienza” University of Rome, 00161 Rome, ItalyOdontostomatological Science and Maxillo facial Surgery Department, “Sapienza” University of Rome, 00161 Rome, ItalyOdontostomatological Science and Maxillo facial Surgery Department, “Sapienza” University of Rome, 00161 Rome, ItalyOdontostomatological Science and Maxillo facial Surgery Department, “Sapienza” University of Rome, 00161 Rome, ItalyOdontostomatological Science and Maxillo facial Surgery Department, “Sapienza” University of Rome, 00161 Rome, ItalyObjective. The acronym MRONJ has been created in order to identify “Medication-Related Osteonecrosis of the Jaw,” observed after the use of Bisphosphonates, RANK ligand inhibitor, and antiangiogenic medications. Only a case of osteonecrosis of the jaw in a Chron’s disease patient following a course of Bisphosphonate and Adalimumab therapy has been recently described, so that it has been supposed that also this medication could promote manifestation of osteonecrosis. Clinical Case. On August, 2014, a 63-year-old female with a history of idiopathic arthritis treated with medical treatment with Adalimumab from 2010 to 2013 presented referring pain in the right mandible. Results. This patient presented with nonexposed osteonecrosis of the jaw after placement, on September, 2010, of four titanium fixtures in the mandible. Conclusions. The authors suggest that the biologic therapy with an anti-TNF-α antibody might promote the manifestation of osteonecrosis and compromise oral healing capacity of the bone.http://dx.doi.org/10.1155/2016/2856926 |
| spellingShingle | Andrea Cassoni Umberto Romeo Valentina Terenzi Marco Della Monaca Oriana Rajabtork Zadeh Ingrid Raponi Maria Teresa Fadda Antonella Polimeni Valentino Valentini Adalimumab: Another Medication Related to Osteonecrosis of the Jaws? Case Reports in Dentistry |
| title | Adalimumab: Another Medication Related to Osteonecrosis of the Jaws? |
| title_full | Adalimumab: Another Medication Related to Osteonecrosis of the Jaws? |
| title_fullStr | Adalimumab: Another Medication Related to Osteonecrosis of the Jaws? |
| title_full_unstemmed | Adalimumab: Another Medication Related to Osteonecrosis of the Jaws? |
| title_short | Adalimumab: Another Medication Related to Osteonecrosis of the Jaws? |
| title_sort | adalimumab another medication related to osteonecrosis of the jaws |
| url | http://dx.doi.org/10.1155/2016/2856926 |
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