Assessment of T Regulatory Cells and Expanded Profiling of Autoantibodies May Offer Novel Biomarkers for the Clinical Management of Systemic Sclerosis and Undifferentiated Connective Tissue Disease
In order to identify disease biomarkers for the clinical and therapeutic management of autoimmune diseases such as systemic sclerosis (SSc) and undifferentiated connective tissue disease (UCTD), we have explored the setting of peripheral T regulatory (T reg) cells and assessed an expanded profile of...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/390563 |
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| author | Paola Cordiali-Fei Anna Mussi Giovanna D'Agosto Elisabetta Trento Valentina Bordignon Silvana Trincone Antonella Vento Isabella Sperduti Antonio Cristaudo Fabrizio Ensoli |
| author_facet | Paola Cordiali-Fei Anna Mussi Giovanna D'Agosto Elisabetta Trento Valentina Bordignon Silvana Trincone Antonella Vento Isabella Sperduti Antonio Cristaudo Fabrizio Ensoli |
| author_sort | Paola Cordiali-Fei |
| collection | DOAJ |
| description | In order to identify disease biomarkers for the clinical and therapeutic management of autoimmune diseases such as systemic sclerosis (SSc) and undifferentiated connective tissue disease (UCTD), we have explored the setting of peripheral T regulatory (T reg) cells and assessed an expanded profile of autoantibodies in patients with SSc, including either limited (lcSSc) or diffuse (dcSSc) disease, and in patients presenting with clinical signs and symptoms of UCTD. A large panel of serum antibodies directed towards nuclear, nucleolar, and cytoplasmic antigens, including well-recognized molecules as well as less frequently tested antigens, was assessed in order to determine whether different antibody profiles might be associated with distinct clinical settings. Beside the well-recognized association between lcSSc and anti-centromeric or dcSSC and anti-topoisomerase-I antibodies, we found a significative association between dcSSc and anti-SRP or anti-PL-7/12 antibodies. In addition, two distinct groups emerged on the basis of anti-RNP or anti-PM-Scl 75/100 antibody production among UCTD patients. The levels of T reg cells were significantly lower in patients with SSc as compared to patients with UCTD or to healthy controls; in patients with lcSSc, T reg cells were inversely correlated to disease duration, suggesting that their levels may represent a marker of disease progression. |
| format | Article |
| id | doaj-art-5d38e2f9428744f8a017e1419ea06ba1 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-5d38e2f9428744f8a017e1419ea06ba12025-02-03T05:57:41ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/390563390563Assessment of T Regulatory Cells and Expanded Profiling of Autoantibodies May Offer Novel Biomarkers for the Clinical Management of Systemic Sclerosis and Undifferentiated Connective Tissue DiseasePaola Cordiali-Fei0Anna Mussi1Giovanna D'Agosto2Elisabetta Trento3Valentina Bordignon4Silvana Trincone5Antonella Vento6Isabella Sperduti7Antonio Cristaudo8Fabrizio Ensoli9Clinical Pathology and Microbiology, San Gallicano Dermatology Institute, Via Elio Chianesi 53, 00144 Rome, ItalyClinical Dermatology, San Gallicano Dermatology Institute, Via Elio Chianesi 53, 00144 Rome, ItalyClinical Pathology and Microbiology, San Gallicano Dermatology Institute, Via Elio Chianesi 53, 00144 Rome, ItalyClinical Pathology and Microbiology, San Gallicano Dermatology Institute, Via Elio Chianesi 53, 00144 Rome, ItalyClinical Pathology and Microbiology, San Gallicano Dermatology Institute, Via Elio Chianesi 53, 00144 Rome, ItalyClinical Dermatology, San Gallicano Dermatology Institute, Via Elio Chianesi 53, 00144 Rome, ItalyClinical Pathology and Microbiology, San Gallicano Dermatology Institute, Via Elio Chianesi 53, 00144 Rome, ItalyBiostatistic Unit, Regina Elena Cancer Institute, Via Elio Chianesi 53, 00144 Rome, ItalyClinical Dermatology, San Gallicano Dermatology Institute, Via Elio Chianesi 53, 00144 Rome, ItalyClinical Pathology and Microbiology, San Gallicano Dermatology Institute, Via Elio Chianesi 53, 00144 Rome, ItalyIn order to identify disease biomarkers for the clinical and therapeutic management of autoimmune diseases such as systemic sclerosis (SSc) and undifferentiated connective tissue disease (UCTD), we have explored the setting of peripheral T regulatory (T reg) cells and assessed an expanded profile of autoantibodies in patients with SSc, including either limited (lcSSc) or diffuse (dcSSc) disease, and in patients presenting with clinical signs and symptoms of UCTD. A large panel of serum antibodies directed towards nuclear, nucleolar, and cytoplasmic antigens, including well-recognized molecules as well as less frequently tested antigens, was assessed in order to determine whether different antibody profiles might be associated with distinct clinical settings. Beside the well-recognized association between lcSSc and anti-centromeric or dcSSC and anti-topoisomerase-I antibodies, we found a significative association between dcSSc and anti-SRP or anti-PL-7/12 antibodies. In addition, two distinct groups emerged on the basis of anti-RNP or anti-PM-Scl 75/100 antibody production among UCTD patients. The levels of T reg cells were significantly lower in patients with SSc as compared to patients with UCTD or to healthy controls; in patients with lcSSc, T reg cells were inversely correlated to disease duration, suggesting that their levels may represent a marker of disease progression.http://dx.doi.org/10.1155/2013/390563 |
| spellingShingle | Paola Cordiali-Fei Anna Mussi Giovanna D'Agosto Elisabetta Trento Valentina Bordignon Silvana Trincone Antonella Vento Isabella Sperduti Antonio Cristaudo Fabrizio Ensoli Assessment of T Regulatory Cells and Expanded Profiling of Autoantibodies May Offer Novel Biomarkers for the Clinical Management of Systemic Sclerosis and Undifferentiated Connective Tissue Disease Clinical and Developmental Immunology |
| title | Assessment of T Regulatory Cells and Expanded Profiling of Autoantibodies May Offer Novel Biomarkers for the Clinical Management of Systemic Sclerosis and Undifferentiated Connective Tissue Disease |
| title_full | Assessment of T Regulatory Cells and Expanded Profiling of Autoantibodies May Offer Novel Biomarkers for the Clinical Management of Systemic Sclerosis and Undifferentiated Connective Tissue Disease |
| title_fullStr | Assessment of T Regulatory Cells and Expanded Profiling of Autoantibodies May Offer Novel Biomarkers for the Clinical Management of Systemic Sclerosis and Undifferentiated Connective Tissue Disease |
| title_full_unstemmed | Assessment of T Regulatory Cells and Expanded Profiling of Autoantibodies May Offer Novel Biomarkers for the Clinical Management of Systemic Sclerosis and Undifferentiated Connective Tissue Disease |
| title_short | Assessment of T Regulatory Cells and Expanded Profiling of Autoantibodies May Offer Novel Biomarkers for the Clinical Management of Systemic Sclerosis and Undifferentiated Connective Tissue Disease |
| title_sort | assessment of t regulatory cells and expanded profiling of autoantibodies may offer novel biomarkers for the clinical management of systemic sclerosis and undifferentiated connective tissue disease |
| url | http://dx.doi.org/10.1155/2013/390563 |
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