Effect of Interval between Neoadjuvant Chemoradiotherapy and Surgery on Oncological Outcome for Rectal Cancer: A Systematic Review and Meta-Analysis
Aim. To evaluate the influence of interval between neoadjuvant chemoradiotherapy (NCRT) and surgery on oncological outcome. Methods. A systematic search was conducted in PubMed, the Cochrane Library, and Embase databases for publications reporting oncological outcomes of patients following rectal ca...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2016/6756859 |
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| _version_ | 1832554835534151680 |
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| author | Xiao-Jie Wang Zheng-Rong Zheng Pan Chi Hui-Ming Lin Xing-Rong Lu Ying Huang |
| author_facet | Xiao-Jie Wang Zheng-Rong Zheng Pan Chi Hui-Ming Lin Xing-Rong Lu Ying Huang |
| author_sort | Xiao-Jie Wang |
| collection | DOAJ |
| description | Aim. To evaluate the influence of interval between neoadjuvant chemoradiotherapy (NCRT) and surgery on oncological outcome. Methods. A systematic search was conducted in PubMed, the Cochrane Library, and Embase databases for publications reporting oncological outcomes of patients following rectal cancer surgery performed at different NCRT-surgery intervals. Relative risk (RR) of pathological complete response (pCR) among different intervals was pooled. Results. Fifteen retrospective cohort studies representing 4431 patients met the inclusion criteria. There was a significantly increased rate of pCR in patients treated with surgery followed 7 or 8 weeks later (RR, 1.45; 95% CI, 1.18–1.78; and P<0.01 and RR, 1.49; 95% CI, 1.15–1.92; and P=0.002, resp.). There is no consistent evidence of improved local control or overall survival with longer or shorter intervals. Conclusion. Performing surgery 7-8 weeks after the end of NCRT results in the highest chance of achieving pCR. For candidates of abdominoperineal resection before NCRT, these data support implementation of prolonging the interval after NCRT to optimize the chances of pCR and perhaps add to the possibility of ultimate organ preservation. |
| format | Article |
| id | doaj-art-5d261476a6524024b8dbbabbc10a588f |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-5d261476a6524024b8dbbabbc10a588f2025-02-03T05:50:26ZengWileyGastroenterology Research and Practice1687-61211687-630X2016-01-01201610.1155/2016/67568596756859Effect of Interval between Neoadjuvant Chemoradiotherapy and Surgery on Oncological Outcome for Rectal Cancer: A Systematic Review and Meta-AnalysisXiao-Jie Wang0Zheng-Rong Zheng1Pan Chi2Hui-Ming Lin3Xing-Rong Lu4Ying Huang5Department of Colorectal Surgery, Union Hospital, Fujian Medical University, Fuzhou, Fujian 350001, ChinaOncology Department, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian 360000, ChinaDepartment of Colorectal Surgery, Union Hospital, Fujian Medical University, Fuzhou, Fujian 350001, ChinaDepartment of Colorectal Surgery, Union Hospital, Fujian Medical University, Fuzhou, Fujian 350001, ChinaDepartment of Colorectal Surgery, Union Hospital, Fujian Medical University, Fuzhou, Fujian 350001, ChinaDepartment of Colorectal Surgery, Union Hospital, Fujian Medical University, Fuzhou, Fujian 350001, ChinaAim. To evaluate the influence of interval between neoadjuvant chemoradiotherapy (NCRT) and surgery on oncological outcome. Methods. A systematic search was conducted in PubMed, the Cochrane Library, and Embase databases for publications reporting oncological outcomes of patients following rectal cancer surgery performed at different NCRT-surgery intervals. Relative risk (RR) of pathological complete response (pCR) among different intervals was pooled. Results. Fifteen retrospective cohort studies representing 4431 patients met the inclusion criteria. There was a significantly increased rate of pCR in patients treated with surgery followed 7 or 8 weeks later (RR, 1.45; 95% CI, 1.18–1.78; and P<0.01 and RR, 1.49; 95% CI, 1.15–1.92; and P=0.002, resp.). There is no consistent evidence of improved local control or overall survival with longer or shorter intervals. Conclusion. Performing surgery 7-8 weeks after the end of NCRT results in the highest chance of achieving pCR. For candidates of abdominoperineal resection before NCRT, these data support implementation of prolonging the interval after NCRT to optimize the chances of pCR and perhaps add to the possibility of ultimate organ preservation.http://dx.doi.org/10.1155/2016/6756859 |
| spellingShingle | Xiao-Jie Wang Zheng-Rong Zheng Pan Chi Hui-Ming Lin Xing-Rong Lu Ying Huang Effect of Interval between Neoadjuvant Chemoradiotherapy and Surgery on Oncological Outcome for Rectal Cancer: A Systematic Review and Meta-Analysis Gastroenterology Research and Practice |
| title | Effect of Interval between Neoadjuvant Chemoradiotherapy and Surgery on Oncological Outcome for Rectal Cancer: A Systematic Review and Meta-Analysis |
| title_full | Effect of Interval between Neoadjuvant Chemoradiotherapy and Surgery on Oncological Outcome for Rectal Cancer: A Systematic Review and Meta-Analysis |
| title_fullStr | Effect of Interval between Neoadjuvant Chemoradiotherapy and Surgery on Oncological Outcome for Rectal Cancer: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Effect of Interval between Neoadjuvant Chemoradiotherapy and Surgery on Oncological Outcome for Rectal Cancer: A Systematic Review and Meta-Analysis |
| title_short | Effect of Interval between Neoadjuvant Chemoradiotherapy and Surgery on Oncological Outcome for Rectal Cancer: A Systematic Review and Meta-Analysis |
| title_sort | effect of interval between neoadjuvant chemoradiotherapy and surgery on oncological outcome for rectal cancer a systematic review and meta analysis |
| url | http://dx.doi.org/10.1155/2016/6756859 |
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