Mettl3/Eed/Ythdc1 regulatory axis controls endometrial receptivity and function

Mettl3/Eed/Ythdc1 regulatory axis controls endometrial receptivity and function

Abstract The regulatory mechanism between N6-methyladenosine (m6A) RNA methylation and histone modification in endometrial receptivity remains poorly understood. In this study, we depict that RIF induced m6A and Mettl3 level restrain, affecting H3K27me3 modification and chromatin accessibility. We s...

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Main Authors: Xiujuan Hu, Jincheng Li, Chenyue Ding, Jing Jiang, Wenjuan Xia, Jiafeng Lu, Huapeng Su, Ming Zhang, Hong Li, Ji-long Liu, Yuan Lin, Qingxia Meng, Boxian Huang
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-07667-y
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