Alternative Macroautophagic Pathways
Macroautophagy is a bulk degradation process that mediates the clearance of long-lived proteins, aggregates, or even whole organelles. This process includes the formation of autophagosomes, double-membrane structures responsible for delivering cargo to lysosomes for degradation. Currently, other alt...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2012/189794 |
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| _version_ | 1832562871593074688 |
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| author | Katrin Juenemann Eric A. Reits |
| author_facet | Katrin Juenemann Eric A. Reits |
| author_sort | Katrin Juenemann |
| collection | DOAJ |
| description | Macroautophagy is a bulk degradation process that mediates the clearance of long-lived proteins, aggregates, or even whole organelles. This process includes the formation of autophagosomes, double-membrane structures responsible for delivering cargo to lysosomes for degradation. Currently, other alternative autophagy pathways have been described, which are independent of macroautophagic key players like Atg5 and Beclin 1 or the lipidation of LC3. In this review, we highlight recent insights in indentifying and understanding the molecular mechanism responsible for alternative autophagic pathways. |
| format | Article |
| id | doaj-art-5d1b6e205b594a119bbe14533854c9df |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-5d1b6e205b594a119bbe14533854c9df2025-02-03T01:21:29ZengWileyInternational Journal of Cell Biology1687-88761687-88842012-01-01201210.1155/2012/189794189794Alternative Macroautophagic PathwaysKatrin Juenemann0Eric A. Reits1Department of Cell Biology and Histology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The NetherlandsDepartment of Cell Biology and Histology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The NetherlandsMacroautophagy is a bulk degradation process that mediates the clearance of long-lived proteins, aggregates, or even whole organelles. This process includes the formation of autophagosomes, double-membrane structures responsible for delivering cargo to lysosomes for degradation. Currently, other alternative autophagy pathways have been described, which are independent of macroautophagic key players like Atg5 and Beclin 1 or the lipidation of LC3. In this review, we highlight recent insights in indentifying and understanding the molecular mechanism responsible for alternative autophagic pathways.http://dx.doi.org/10.1155/2012/189794 |
| spellingShingle | Katrin Juenemann Eric A. Reits Alternative Macroautophagic Pathways International Journal of Cell Biology |
| title | Alternative Macroautophagic Pathways |
| title_full | Alternative Macroautophagic Pathways |
| title_fullStr | Alternative Macroautophagic Pathways |
| title_full_unstemmed | Alternative Macroautophagic Pathways |
| title_short | Alternative Macroautophagic Pathways |
| title_sort | alternative macroautophagic pathways |
| url | http://dx.doi.org/10.1155/2012/189794 |
| work_keys_str_mv | AT katrinjuenemann alternativemacroautophagicpathways AT ericareits alternativemacroautophagicpathways |