The Carnivore Connection Hypothesis: Revisited
The “Carnivore Connection” hypothesizes that, during human evolution, a scarcity of dietary carbohydrate in diets with low plant : animal subsistence ratios led to insulin resistance providing a survival and reproductive advantage with selection of genes for insulin resistance. The selection pressur...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2012/258624 |
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| author | Jennie C. Brand-Miller Hayley J. Griffin Stephen Colagiuri |
| author_facet | Jennie C. Brand-Miller Hayley J. Griffin Stephen Colagiuri |
| author_sort | Jennie C. Brand-Miller |
| collection | DOAJ |
| description | The “Carnivore Connection” hypothesizes that, during human evolution, a scarcity of dietary carbohydrate in diets with low plant : animal subsistence ratios led to insulin resistance providing a survival and reproductive advantage with selection of genes for insulin resistance. The selection pressure was relaxed at the beginning of the Agricultural Revolution when large quantities of cereals first entered human diets. The “Carnivore Connection” explains the high prevalence of intrinsic insulin resistance and type 2 diabetes in populations that transition rapidly from traditional diets with a low-glycemic load, to high-carbohydrate, high-glycemic index diets that characterize modern diets. Selection pressure has been relaxed longest in European populations, explaining a lower prevalence of insulin resistance and type 2 diabetes, despite recent exposure to famine and food scarcity. Increasing obesity and habitual consumption of high-glycemic-load diets worsens insulin resistance and increases the risk of type 2 diabetes in all populations. |
| format | Article |
| id | doaj-art-5d152c97e31c4171a6437bdbcdf4ecf6 |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-5d152c97e31c4171a6437bdbcdf4ecf62025-02-03T01:26:19ZengWileyJournal of Obesity2090-07082090-07162012-01-01201210.1155/2012/258624258624The Carnivore Connection Hypothesis: RevisitedJennie C. Brand-Miller0Hayley J. Griffin1Stephen Colagiuri2The Boden Institute of Obesity, Nutrition, Exercise and Eating Disorders, The University of Sydney, G89 Medical Foundation Building K25, NSW 2006, Sydney, Australia11 Nursery Street, Hornsby, NSW 2077, Sydney, AustraliaThe Boden Institute of Obesity, Nutrition, Exercise and Eating Disorders, The University of Sydney, G89 Medical Foundation Building K25, NSW 2006, Sydney, AustraliaThe “Carnivore Connection” hypothesizes that, during human evolution, a scarcity of dietary carbohydrate in diets with low plant : animal subsistence ratios led to insulin resistance providing a survival and reproductive advantage with selection of genes for insulin resistance. The selection pressure was relaxed at the beginning of the Agricultural Revolution when large quantities of cereals first entered human diets. The “Carnivore Connection” explains the high prevalence of intrinsic insulin resistance and type 2 diabetes in populations that transition rapidly from traditional diets with a low-glycemic load, to high-carbohydrate, high-glycemic index diets that characterize modern diets. Selection pressure has been relaxed longest in European populations, explaining a lower prevalence of insulin resistance and type 2 diabetes, despite recent exposure to famine and food scarcity. Increasing obesity and habitual consumption of high-glycemic-load diets worsens insulin resistance and increases the risk of type 2 diabetes in all populations.http://dx.doi.org/10.1155/2012/258624 |
| spellingShingle | Jennie C. Brand-Miller Hayley J. Griffin Stephen Colagiuri The Carnivore Connection Hypothesis: Revisited Journal of Obesity |
| title | The Carnivore Connection Hypothesis: Revisited |
| title_full | The Carnivore Connection Hypothesis: Revisited |
| title_fullStr | The Carnivore Connection Hypothesis: Revisited |
| title_full_unstemmed | The Carnivore Connection Hypothesis: Revisited |
| title_short | The Carnivore Connection Hypothesis: Revisited |
| title_sort | carnivore connection hypothesis revisited |
| url | http://dx.doi.org/10.1155/2012/258624 |
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