Specific Roles of MicroRNAs in Their Interactions with Environmental Factors
MicroRNAs (miRNAs) have emerged as critical regulators of gene expression by modulating numerous target mRNAs expression at posttranscriptional level. Extensive studies have shown that miRNAs are critical in various important biological processes, including cell growth, proliferation, differentiati...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Nucleic Acids |
| Online Access: | http://dx.doi.org/10.1155/2012/978384 |
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| _version_ | 1832566759097368576 |
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| author | Juan Wang Qinghua Cui |
| author_facet | Juan Wang Qinghua Cui |
| author_sort | Juan Wang |
| collection | DOAJ |
| description | MicroRNAs (miRNAs) have emerged as critical regulators of gene expression by modulating numerous target mRNAs expression at posttranscriptional level. Extensive studies have shown that miRNAs are critical in various important biological processes, including cell growth, proliferation, differentiation, development, and apoptosis. In terms of their importance, miRNA dysfunction has been associated with a broad range of diseases. Increased number of studies have shown that miRNAs can functionally interact with a wide spectrum of environmental factors (EFs) including drugs, industrial materials, virus and bacterial pathogens, cigarette smoking, alcohol, nutrition, sleep, exercise, stress, and radiation. More importantly, the interactions between miRNAs and EFs have been shown to play critical roles in determining abnormal phenotypes and diseases. In this paper, we propose an outline of the current knowledge about specific roles of miRNAs in their interactions with various EFs and analyze the literatures detailing miRNAs-EFs interactions in the context of various of diseases. |
| format | Article |
| id | doaj-art-5d054f2a387c4e95b2454abe12097480 |
| institution | Kabale University |
| issn | 2090-0201 2090-021X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nucleic Acids |
| spelling | doaj-art-5d054f2a387c4e95b2454abe120974802025-02-03T01:03:16ZengWileyJournal of Nucleic Acids2090-02012090-021X2012-01-01201210.1155/2012/978384978384Specific Roles of MicroRNAs in Their Interactions with Environmental FactorsJuan Wang0Qinghua Cui1Department of Biomedical Informatics, Peking University Health Science Center, Beijing 100191, ChinaDepartment of Biomedical Informatics, Peking University Health Science Center, Beijing 100191, ChinaMicroRNAs (miRNAs) have emerged as critical regulators of gene expression by modulating numerous target mRNAs expression at posttranscriptional level. Extensive studies have shown that miRNAs are critical in various important biological processes, including cell growth, proliferation, differentiation, development, and apoptosis. In terms of their importance, miRNA dysfunction has been associated with a broad range of diseases. Increased number of studies have shown that miRNAs can functionally interact with a wide spectrum of environmental factors (EFs) including drugs, industrial materials, virus and bacterial pathogens, cigarette smoking, alcohol, nutrition, sleep, exercise, stress, and radiation. More importantly, the interactions between miRNAs and EFs have been shown to play critical roles in determining abnormal phenotypes and diseases. In this paper, we propose an outline of the current knowledge about specific roles of miRNAs in their interactions with various EFs and analyze the literatures detailing miRNAs-EFs interactions in the context of various of diseases.http://dx.doi.org/10.1155/2012/978384 |
| spellingShingle | Juan Wang Qinghua Cui Specific Roles of MicroRNAs in Their Interactions with Environmental Factors Journal of Nucleic Acids |
| title | Specific Roles of MicroRNAs in Their Interactions with Environmental Factors |
| title_full | Specific Roles of MicroRNAs in Their Interactions with Environmental Factors |
| title_fullStr | Specific Roles of MicroRNAs in Their Interactions with Environmental Factors |
| title_full_unstemmed | Specific Roles of MicroRNAs in Their Interactions with Environmental Factors |
| title_short | Specific Roles of MicroRNAs in Their Interactions with Environmental Factors |
| title_sort | specific roles of micrornas in their interactions with environmental factors |
| url | http://dx.doi.org/10.1155/2012/978384 |
| work_keys_str_mv | AT juanwang specificrolesofmicrornasintheirinteractionswithenvironmentalfactors AT qinghuacui specificrolesofmicrornasintheirinteractionswithenvironmentalfactors |