Functional and Biological Role of Endothelial Precursor Cells in Tumour Progression: A New Potential Therapeutic Target in Haematological Malignancies
It was believed that vasculogenesis occurred only during embryo life and that postnatal formation of vessels arose from angiogenesis. Recent findings demonstrate the existence of Endothelial Precursor Cells (EPCs), which take partin postnatal vasculogenesis. EPCs are recruited from th...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/7954580 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832548119017947136 |
|---|---|
| author | Antonia Reale Assunta Melaccio Aurelia Lamanuzzi Ilaria Saltarella Franco Dammacco Angelo Vacca Roberto Ria |
| author_facet | Antonia Reale Assunta Melaccio Aurelia Lamanuzzi Ilaria Saltarella Franco Dammacco Angelo Vacca Roberto Ria |
| author_sort | Antonia Reale |
| collection | DOAJ |
| description | It was believed that vasculogenesis occurred only during embryo life and that postnatal formation of vessels arose from angiogenesis. Recent findings demonstrate the existence of Endothelial Precursor Cells (EPCs), which take partin postnatal vasculogenesis. EPCs are recruited from the bone marrow under the stimulation of growth factors and cytokines and reach the sites of neovascularization in both physiological and pathological conditions such as malignancies where they contribute to the “angiogenic switch” and tumor progression. An implementation of circulating EPCs in the bloodstream of patients with haematological malignancies has been demonstrated. This increase is strictly related to the bone marrow microvessel density and correlated with a poor prognosis. The EPCs characterization is a very complex process and still under investigation. This literature review aims to provide an overview of the functional and biological role of EPCs in haematological malignancies and to investigate their potential as a new cancer therapeutic target. |
| format | Article |
| id | doaj-art-5d051b160bdd4a7a9dc6a2d1b79e325c |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-5d051b160bdd4a7a9dc6a2d1b79e325c2025-02-03T06:42:05ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/79545807954580Functional and Biological Role of Endothelial Precursor Cells in Tumour Progression: A New Potential Therapeutic Target in Haematological MalignanciesAntonia Reale0Assunta Melaccio1Aurelia Lamanuzzi2Ilaria Saltarella3Franco Dammacco4Angelo Vacca5Roberto Ria6Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, 70124 Bari, ItalyDepartment of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, 70124 Bari, ItalyDepartment of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, 70124 Bari, ItalyDepartment of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, 70124 Bari, ItalyDepartment of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, 70124 Bari, ItalyDepartment of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, 70124 Bari, ItalyDepartment of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, 70124 Bari, ItalyIt was believed that vasculogenesis occurred only during embryo life and that postnatal formation of vessels arose from angiogenesis. Recent findings demonstrate the existence of Endothelial Precursor Cells (EPCs), which take partin postnatal vasculogenesis. EPCs are recruited from the bone marrow under the stimulation of growth factors and cytokines and reach the sites of neovascularization in both physiological and pathological conditions such as malignancies where they contribute to the “angiogenic switch” and tumor progression. An implementation of circulating EPCs in the bloodstream of patients with haematological malignancies has been demonstrated. This increase is strictly related to the bone marrow microvessel density and correlated with a poor prognosis. The EPCs characterization is a very complex process and still under investigation. This literature review aims to provide an overview of the functional and biological role of EPCs in haematological malignancies and to investigate their potential as a new cancer therapeutic target.http://dx.doi.org/10.1155/2016/7954580 |
| spellingShingle | Antonia Reale Assunta Melaccio Aurelia Lamanuzzi Ilaria Saltarella Franco Dammacco Angelo Vacca Roberto Ria Functional and Biological Role of Endothelial Precursor Cells in Tumour Progression: A New Potential Therapeutic Target in Haematological Malignancies Stem Cells International |
| title | Functional and Biological Role of Endothelial Precursor Cells in Tumour Progression: A New Potential Therapeutic Target in Haematological Malignancies |
| title_full | Functional and Biological Role of Endothelial Precursor Cells in Tumour Progression: A New Potential Therapeutic Target in Haematological Malignancies |
| title_fullStr | Functional and Biological Role of Endothelial Precursor Cells in Tumour Progression: A New Potential Therapeutic Target in Haematological Malignancies |
| title_full_unstemmed | Functional and Biological Role of Endothelial Precursor Cells in Tumour Progression: A New Potential Therapeutic Target in Haematological Malignancies |
| title_short | Functional and Biological Role of Endothelial Precursor Cells in Tumour Progression: A New Potential Therapeutic Target in Haematological Malignancies |
| title_sort | functional and biological role of endothelial precursor cells in tumour progression a new potential therapeutic target in haematological malignancies |
| url | http://dx.doi.org/10.1155/2016/7954580 |
| work_keys_str_mv | AT antoniareale functionalandbiologicalroleofendothelialprecursorcellsintumourprogressionanewpotentialtherapeutictargetinhaematologicalmalignancies AT assuntamelaccio functionalandbiologicalroleofendothelialprecursorcellsintumourprogressionanewpotentialtherapeutictargetinhaematologicalmalignancies AT aurelialamanuzzi functionalandbiologicalroleofendothelialprecursorcellsintumourprogressionanewpotentialtherapeutictargetinhaematologicalmalignancies AT ilariasaltarella functionalandbiologicalroleofendothelialprecursorcellsintumourprogressionanewpotentialtherapeutictargetinhaematologicalmalignancies AT francodammacco functionalandbiologicalroleofendothelialprecursorcellsintumourprogressionanewpotentialtherapeutictargetinhaematologicalmalignancies AT angelovacca functionalandbiologicalroleofendothelialprecursorcellsintumourprogressionanewpotentialtherapeutictargetinhaematologicalmalignancies AT robertoria functionalandbiologicalroleofendothelialprecursorcellsintumourprogressionanewpotentialtherapeutictargetinhaematologicalmalignancies |