Design of an innovative nanovehicle to enhance brain permeability of a novel 5-HT6 receptor antagonist

Design of an innovative nanovehicle to enhance brain permeability of a novel 5-HT6 receptor antagonist

An innovative nanovehicle based on lipid nanocapsules (LNC) was designed to facilitate the passage of a new 5-HT6 receptor antagonist, namely PUC-10, through the blood-brain barrier. PUC-10 is a new synthetic N-arylsulfonylindole that has demonstrated potent 5-HT6 receptor antagonist activity, but i...

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Bibliographic Details
Main Authors:	María Javiera Alvarez-Figueroa, Francisco Nuñez-Navarro, Gonzalo Recabarren-Gajardo, José Vicente González-Aramundiz
Format:	Article
Language:	English
Published:	Elsevier 2024-12-01
Series:	International Journal of Pharmaceutics: X
Subjects:	Lipid nanocapsules PAMPA-BBB Brain permeability Arylsulfonylindoles 5-HT6 receptor
Online Access:	http://www.sciencedirect.com/science/article/pii/S2590156724000689
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