The Effect of Mitochondrial Dysfunction on Cytosolic Nucleotide Metabolism
Several enzymes of the metabolic pathways responsible for metabolism of cytosolic ribonucleotides and deoxyribonucleotides are located in mitochondria. Studies described in this paper suggest dysfunction of the mitochondria to affect these metabolic pathways and limit the available levels of cytosol...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Journal of Nucleic Acids |
| Online Access: | http://dx.doi.org/10.4061/2010/701518 |
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| _version_ | 1832560384145358848 |
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| author | Claus Desler Anne Lykke Lene Juel Rasmussen |
| author_facet | Claus Desler Anne Lykke Lene Juel Rasmussen |
| author_sort | Claus Desler |
| collection | DOAJ |
| description | Several enzymes of the metabolic pathways responsible for metabolism of cytosolic ribonucleotides and deoxyribonucleotides are located in mitochondria. Studies described in this paper suggest dysfunction of the mitochondria to affect these metabolic pathways and limit the available levels of cytosolic ribonucleotides and deoxyribonucleotides, which in turn can result in aberrant RNA and DNA synthesis. Mitochondrial dysfunction has been linked to genomic instability, and it is possible that the limiting effect of mitochondrial dysfunction on the levels of nucleotides and resulting aberrant RNA and DNA synthesis in part can be responsible for this link. This paper summarizes the parts of the metabolic pathways responsible for nucleotide metabolism that can be affected by mitochondrial dysfunction. |
| format | Article |
| id | doaj-art-5ce8b11de1284b0c996b626491f18718 |
| institution | Kabale University |
| issn | 2090-021X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nucleic Acids |
| spelling | doaj-art-5ce8b11de1284b0c996b626491f187182025-02-03T01:27:38ZengWileyJournal of Nucleic Acids2090-021X2010-01-01201010.4061/2010/701518701518The Effect of Mitochondrial Dysfunction on Cytosolic Nucleotide MetabolismClaus Desler0Anne Lykke1Lene Juel Rasmussen2Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen, DenmarkDepartment of Science, Systems and Models, Roskilde University, 4000 Roskilde, DenmarkCenter for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen, DenmarkSeveral enzymes of the metabolic pathways responsible for metabolism of cytosolic ribonucleotides and deoxyribonucleotides are located in mitochondria. Studies described in this paper suggest dysfunction of the mitochondria to affect these metabolic pathways and limit the available levels of cytosolic ribonucleotides and deoxyribonucleotides, which in turn can result in aberrant RNA and DNA synthesis. Mitochondrial dysfunction has been linked to genomic instability, and it is possible that the limiting effect of mitochondrial dysfunction on the levels of nucleotides and resulting aberrant RNA and DNA synthesis in part can be responsible for this link. This paper summarizes the parts of the metabolic pathways responsible for nucleotide metabolism that can be affected by mitochondrial dysfunction.http://dx.doi.org/10.4061/2010/701518 |
| spellingShingle | Claus Desler Anne Lykke Lene Juel Rasmussen The Effect of Mitochondrial Dysfunction on Cytosolic Nucleotide Metabolism Journal of Nucleic Acids |
| title | The Effect of Mitochondrial Dysfunction on Cytosolic Nucleotide Metabolism |
| title_full | The Effect of Mitochondrial Dysfunction on Cytosolic Nucleotide Metabolism |
| title_fullStr | The Effect of Mitochondrial Dysfunction on Cytosolic Nucleotide Metabolism |
| title_full_unstemmed | The Effect of Mitochondrial Dysfunction on Cytosolic Nucleotide Metabolism |
| title_short | The Effect of Mitochondrial Dysfunction on Cytosolic Nucleotide Metabolism |
| title_sort | effect of mitochondrial dysfunction on cytosolic nucleotide metabolism |
| url | http://dx.doi.org/10.4061/2010/701518 |
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