Lipopolysaccharide-induced memory impairment in rats is preventable using 7-nitroindazole
Inflammation and oxidative stress have important roles in memory impairment. The effect of 7-nitroindazole (7NI) on lipopolysaccharide (LPS)-induced memory impairment was investigated. Rats were used, divided into four groups that were treated as follows: (1) control (saline); (2) LPS; (3) 7NI-LPS;...
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações
2015-09-01
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000900784&lng=en&tlng=en |
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| author | Akbar Anaeigoudari Mohammad Naser Shafei Mohammad Soukhtanloo Hamid Reza Sadeghnia Parham Reisi Farimah Beheshti Reza Mohebbati Seyed Mojtaba Mousavi Mahmoud Hosseini |
| author_facet | Akbar Anaeigoudari Mohammad Naser Shafei Mohammad Soukhtanloo Hamid Reza Sadeghnia Parham Reisi Farimah Beheshti Reza Mohebbati Seyed Mojtaba Mousavi Mahmoud Hosseini |
| author_sort | Akbar Anaeigoudari |
| collection | DOAJ |
| description | Inflammation and oxidative stress have important roles in memory impairment. The effect of 7-nitroindazole (7NI) on lipopolysaccharide (LPS)-induced memory impairment was investigated. Rats were used, divided into four groups that were treated as follows: (1) control (saline); (2) LPS; (3) 7NI-LPS; and (4) 7NI before passive avoidance (PA). In the LPS group, the latency for entering the dark compartment was shorter than in the controls (p < 0.01 and p < 0.001); while in the 7NI-LPS group, it was longer than in the LPS group (p < 0.01 and p < 0.001). Malondialdehyde (MDA) and nitric oxide (NO) metabolite concentrations in the brain tissues of the LPS group were higher than in the controls (p < 0.001 and p < 0.05); while in the 7NI-LPS group, they were lower than in the LPS group (p < 0.001 and p < 0.05, respectively). The thiol content in the brain of the LPS group was lower than in the controls (p < 0.001); while in the 7NI-LPS group, it was higher than in the LPS group (p < 0.001). It is suggested that brain tissue oxidative damage and NO elevation have a role in the deleterious effects of LPS on memory retention that are preventable using 7NI. |
| format | Article |
| id | doaj-art-5ce793e42e5d40fc8d184e9c2e91fa68 |
| institution | DOAJ |
| issn | 1678-4227 |
| language | English |
| publishDate | 2015-09-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-5ce793e42e5d40fc8d184e9c2e91fa682025-08-20T03:18:12ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272015-09-0173978479010.1590/0004-282X20150121S0004-282X2015000900784Lipopolysaccharide-induced memory impairment in rats is preventable using 7-nitroindazoleAkbar AnaeigoudariMohammad Naser ShafeiMohammad SoukhtanlooHamid Reza SadeghniaParham ReisiFarimah BeheshtiReza MohebbatiSeyed Mojtaba MousaviMahmoud HosseiniInflammation and oxidative stress have important roles in memory impairment. The effect of 7-nitroindazole (7NI) on lipopolysaccharide (LPS)-induced memory impairment was investigated. Rats were used, divided into four groups that were treated as follows: (1) control (saline); (2) LPS; (3) 7NI-LPS; and (4) 7NI before passive avoidance (PA). In the LPS group, the latency for entering the dark compartment was shorter than in the controls (p < 0.01 and p < 0.001); while in the 7NI-LPS group, it was longer than in the LPS group (p < 0.01 and p < 0.001). Malondialdehyde (MDA) and nitric oxide (NO) metabolite concentrations in the brain tissues of the LPS group were higher than in the controls (p < 0.001 and p < 0.05); while in the 7NI-LPS group, they were lower than in the LPS group (p < 0.001 and p < 0.05, respectively). The thiol content in the brain of the LPS group was lower than in the controls (p < 0.001); while in the 7NI-LPS group, it was higher than in the LPS group (p < 0.001). It is suggested that brain tissue oxidative damage and NO elevation have a role in the deleterious effects of LPS on memory retention that are preventable using 7NI.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000900784&lng=en&tlng=enaprendizadomemórialipopolissacarídeo7NI |
| spellingShingle | Akbar Anaeigoudari Mohammad Naser Shafei Mohammad Soukhtanloo Hamid Reza Sadeghnia Parham Reisi Farimah Beheshti Reza Mohebbati Seyed Mojtaba Mousavi Mahmoud Hosseini Lipopolysaccharide-induced memory impairment in rats is preventable using 7-nitroindazole Arquivos de Neuro-Psiquiatria aprendizado memória lipopolissacarídeo 7NI |
| title | Lipopolysaccharide-induced memory impairment in rats is preventable using 7-nitroindazole |
| title_full | Lipopolysaccharide-induced memory impairment in rats is preventable using 7-nitroindazole |
| title_fullStr | Lipopolysaccharide-induced memory impairment in rats is preventable using 7-nitroindazole |
| title_full_unstemmed | Lipopolysaccharide-induced memory impairment in rats is preventable using 7-nitroindazole |
| title_short | Lipopolysaccharide-induced memory impairment in rats is preventable using 7-nitroindazole |
| title_sort | lipopolysaccharide induced memory impairment in rats is preventable using 7 nitroindazole |
| topic | aprendizado memória lipopolissacarídeo 7NI |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000900784&lng=en&tlng=en |
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