Reteplase Fc-fusions produced in N. benthamiana are able to dissolve blood clots ex vivo.

Reteplase Fc-fusions produced in N. benthamiana are able to dissolve blood clots ex vivo.

Thrombolytic and fibrinolytic therapies are effective treatments to dissolve blood clots in stroke therapy. Thrombolytic drugs activate plasminogen to its cleaved form plasmin, a proteolytic enzyme that breaks the crosslinks between fibrin molecules. The FDA-approved human tissue plasminogen activat...

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Bibliographic Details
Main Authors: Shiva Izadi, Mokhtar Jalali Javaran, Sajad Rashidi Monfared, Alexandra Castilho
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0260796&type=printable
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