Elevated Serum C-Reactive Protein and Markers of Sleep Disordered Breathing
Background. Previous studies indicated sleep-disordered breathing (SDB) is associated with cardiovascular disease (CVD). Systemic inflammation is recognized as a risk factor for CVD. Studies examining SDB and inflammation are limited. Methods. We studied sleep duration, snoring, snorting, and daytim...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Vascular Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/914593 |
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| author | R. Constance Wiener Rouxin Zhang Anoop Shankar |
| author_facet | R. Constance Wiener Rouxin Zhang Anoop Shankar |
| author_sort | R. Constance Wiener |
| collection | DOAJ |
| description | Background. Previous studies indicated sleep-disordered breathing (SDB) is associated with cardiovascular disease (CVD). Systemic inflammation is recognized as a risk factor for CVD. Studies examining SDB and inflammation are limited. Methods. We studied sleep duration, snoring, snorting, and daytime sleepiness, and an additive SDB score. The main outcome was a C-reactive protein (CRP) of >1 mg/dL. Results. Snoring, snorting, daytime sleepiness, and sleeping >7 or <7 hours, and the additive score were significantly associated with high CRP. The additive score was not associated in men but moderately associated in women in a multivariable model adjusting for age, gender, race/ethnicity, education, smoking, hypertension, alcohol intake, physical activity, body mass index, depression, diabetes, hypertension, and total cholesterol (P-interaction =0.42). For race/ethnicity, the association was strongest in Mexican Americans/others, modest in Non-Hispanic whites, and absent in Non-Hispanic blacks (P-interaction =0.07). Conclusions. The association between SDB and high CRP was present mainly in women and Mexican Americans, implying SDB has a residual, independent association with inflammation after controlling for lifestyle and metabolic risk factors like BMI, physical activity, depression, diabetes, and cholesterol. |
| format | Article |
| id | doaj-art-5ce490217d784369ae3e37a968d768ec |
| institution | Kabale University |
| issn | 2090-2824 2090-2832 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Vascular Medicine |
| spelling | doaj-art-5ce490217d784369ae3e37a968d768ec2025-02-03T01:26:52ZengWileyInternational Journal of Vascular Medicine2090-28242090-28322012-01-01201210.1155/2012/914593914593Elevated Serum C-Reactive Protein and Markers of Sleep Disordered BreathingR. Constance Wiener0Rouxin Zhang1Anoop Shankar2Department of Dental Practice and Rural Health, West Virginia University, P.O. Box 9448, Health Sciences North, Morgantown, WV 26506, USADepartment of Dental Practice and Rural Health, West Virginia University, P.O. Box 9448, Health Sciences North, Morgantown, WV 26506, USADepartment of Dental Practice and Rural Health, West Virginia University, P.O. Box 9448, Health Sciences North, Morgantown, WV 26506, USABackground. Previous studies indicated sleep-disordered breathing (SDB) is associated with cardiovascular disease (CVD). Systemic inflammation is recognized as a risk factor for CVD. Studies examining SDB and inflammation are limited. Methods. We studied sleep duration, snoring, snorting, and daytime sleepiness, and an additive SDB score. The main outcome was a C-reactive protein (CRP) of >1 mg/dL. Results. Snoring, snorting, daytime sleepiness, and sleeping >7 or <7 hours, and the additive score were significantly associated with high CRP. The additive score was not associated in men but moderately associated in women in a multivariable model adjusting for age, gender, race/ethnicity, education, smoking, hypertension, alcohol intake, physical activity, body mass index, depression, diabetes, hypertension, and total cholesterol (P-interaction =0.42). For race/ethnicity, the association was strongest in Mexican Americans/others, modest in Non-Hispanic whites, and absent in Non-Hispanic blacks (P-interaction =0.07). Conclusions. The association between SDB and high CRP was present mainly in women and Mexican Americans, implying SDB has a residual, independent association with inflammation after controlling for lifestyle and metabolic risk factors like BMI, physical activity, depression, diabetes, and cholesterol.http://dx.doi.org/10.1155/2012/914593 |
| spellingShingle | R. Constance Wiener Rouxin Zhang Anoop Shankar Elevated Serum C-Reactive Protein and Markers of Sleep Disordered Breathing International Journal of Vascular Medicine |
| title | Elevated Serum C-Reactive Protein and Markers of Sleep Disordered Breathing |
| title_full | Elevated Serum C-Reactive Protein and Markers of Sleep Disordered Breathing |
| title_fullStr | Elevated Serum C-Reactive Protein and Markers of Sleep Disordered Breathing |
| title_full_unstemmed | Elevated Serum C-Reactive Protein and Markers of Sleep Disordered Breathing |
| title_short | Elevated Serum C-Reactive Protein and Markers of Sleep Disordered Breathing |
| title_sort | elevated serum c reactive protein and markers of sleep disordered breathing |
| url | http://dx.doi.org/10.1155/2012/914593 |
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