Pharmaceutical, Pharmacokinetic and Other Considerations for Intravenous to Oral Stepdown Therapy

Parenteral to oral stepdown therapy represents an effective cost containment strategy which can minimize intravenous therapy associated morbidity and may facilitate earlier hospital discharge. Several oral anti-infectives are available to the prescriber and there are as many opportunities to stepdow...

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Main Author: Peter J Jewesson
Format: Article
Language:English
Published: Wiley 1995-01-01
Series:Canadian Journal of Infectious Diseases
Online Access:http://dx.doi.org/10.1155/1995/975209
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author Peter J Jewesson
author_facet Peter J Jewesson
author_sort Peter J Jewesson
collection DOAJ
description Parenteral to oral stepdown therapy represents an effective cost containment strategy which can minimize intravenous therapy associated morbidity and may facilitate earlier hospital discharge. Several oral anti-infectives are available to the prescriber and there are as many opportunities to stepdown to the same agent as there are to other drugs of the same class or other classes. Recognition of the pharmacokinetic characteristics of these oral agents is essential lo successful therapy. Good bioavailability may not always be assured. A simple regimen will promote compliance.
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spelling doaj-art-5ce1e48ed7ff4255904bbbb5a85a7ea72025-02-03T01:11:18ZengWileyCanadian Journal of Infectious Diseases1180-23321995-01-016Suppl A11A16A10.1155/1995/975209Pharmaceutical, Pharmacokinetic and Other Considerations for Intravenous to Oral Stepdown TherapyPeter J Jewesson0Faculty of Pharmaceutical Sciences, University of British Columbia, Department of Pharmacy, Vancouver Hospital and Health Sciences Centre, Vancouver, British Columbia, CanadaParenteral to oral stepdown therapy represents an effective cost containment strategy which can minimize intravenous therapy associated morbidity and may facilitate earlier hospital discharge. Several oral anti-infectives are available to the prescriber and there are as many opportunities to stepdown to the same agent as there are to other drugs of the same class or other classes. Recognition of the pharmacokinetic characteristics of these oral agents is essential lo successful therapy. Good bioavailability may not always be assured. A simple regimen will promote compliance.http://dx.doi.org/10.1155/1995/975209
spellingShingle Peter J Jewesson
Pharmaceutical, Pharmacokinetic and Other Considerations for Intravenous to Oral Stepdown Therapy
Canadian Journal of Infectious Diseases
title Pharmaceutical, Pharmacokinetic and Other Considerations for Intravenous to Oral Stepdown Therapy
title_full Pharmaceutical, Pharmacokinetic and Other Considerations for Intravenous to Oral Stepdown Therapy
title_fullStr Pharmaceutical, Pharmacokinetic and Other Considerations for Intravenous to Oral Stepdown Therapy
title_full_unstemmed Pharmaceutical, Pharmacokinetic and Other Considerations for Intravenous to Oral Stepdown Therapy
title_short Pharmaceutical, Pharmacokinetic and Other Considerations for Intravenous to Oral Stepdown Therapy
title_sort pharmaceutical pharmacokinetic and other considerations for intravenous to oral stepdown therapy
url http://dx.doi.org/10.1155/1995/975209
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