Effects of genetic ablation and pharmacological inhibition of HuR on gene expression, iron metabolism, and hormone levels

Effects of genetic ablation and pharmacological inhibition of HuR on gene expression, iron metabolism, and hormone levels

Abstract Background HuR/ELAV1, a ubiquitous RNA-binding protein, belongs to the RNA-binding protein family and is crucial for stabilizing and regulating the translation of various mRNA targets, influencing gene expression. Elevated HuR levels are associated with multiple disorders, including cancer...

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Main Authors: Nathalie Idlin, Sivakumar Krishnamoorthy, Magdalena Wolczyk, Mouad Fakhri, Michal Lechowski, Natalia Stec, Jacek Milek, Pratik Kumar Mandal, Jaroslaw Cendrowski, Christos Spanos, Magdalena Dziembowska, Katarzyna Mleczko-Sanecka, Juri Rappsilber, Gracjan Michlewski
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BMC Biology
Subjects:
HuR
ELAVL1
Eltrombopag
Iron metabolism
Online Access:https://doi.org/10.1186/s12915-025-02131-z
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