Hidden Metabolic Disturbances in Women with Normal Glucose Tolerance Five Years after Gestational Diabetes
Background. The study aimed to assess whether women with prior gestational diabetes (pGDM), despite maintenance of normal glucose tolerance (NGT) five years after delivery, display metabolic disturbances compared to healthy controls. Methods. 45 pGDM with NGT were compared to 18 women without a his...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/342938 |
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| author | Yvonne Winhofer Andrea Tura Anita Thomas Thomas Prikoszovich Christine Winzer Giovanni Pacini Anton Luger Alexandra Kautzky-Willer |
| author_facet | Yvonne Winhofer Andrea Tura Anita Thomas Thomas Prikoszovich Christine Winzer Giovanni Pacini Anton Luger Alexandra Kautzky-Willer |
| author_sort | Yvonne Winhofer |
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| description | Background. The study aimed to assess whether women with prior gestational diabetes (pGDM), despite maintenance of normal glucose tolerance (NGT) five years after delivery, display metabolic disturbances compared to healthy controls. Methods. 45 pGDM with NGT were compared to 18 women without a history of GDM (CON), matched for age (37.0 ± 4.1 versus 35.2 ± 5.3, P=ns) and BMI (24.3 ± 3.1 versus 23.3 ± 3.3, P=ns). Metabolic parameters were derived from oral and intravenous glucose tolerance tests; furthermore lipid profile, C-reactive protein (CRP), adiponectin, leptin, and glucagon were assessed. Results. Five years postpartum, pGDM had increased glucose concentrations during the OGTT (AUC: 1.12 ± 0.15 versus 1.0 ± 0.12 mol/L * min, P=0.003) and insulin sensitivity was decreased compared to CON (OGIS: 467.2 ± 64.1 versus 510.6 ± 53.1 mL/min * m2, P=0.01). pGDM had lower adiponectin (8.1 ± 2.6 versus 12.6 ± 5.3, P<0.008) but increased waist circumference and CRP compared to CON. Conclusions. Despite diagnosis of normal glucose tolerance, pGDM are characterized by hyperglycemia and insulin resistance compared to healthy controls, accompanied by decreased adiponectin and increased CRP concentrations, thus linking metabolic disturbances to an increased cardiovascular risk in pGDM. |
| format | Article |
| id | doaj-art-5cd94bc85fc14185bb4df2f227d80339 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
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| series | International Journal of Endocrinology |
| spelling | doaj-art-5cd94bc85fc14185bb4df2f227d803392025-02-03T01:01:08ZengWileyInternational Journal of Endocrinology1687-83371687-83452015-01-01201510.1155/2015/342938342938Hidden Metabolic Disturbances in Women with Normal Glucose Tolerance Five Years after Gestational DiabetesYvonne Winhofer0Andrea Tura1Anita Thomas2Thomas Prikoszovich3Christine Winzer4Giovanni Pacini5Anton Luger6Alexandra Kautzky-Willer7Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, AustriaMetabolic Unit, Institute of Biomedical Engineering, National Research Council, 35127 Padova, ItalyDivision of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, AustriaDivision of Nephrology, Department of Internal Medicine III, Medical University of Vienna, 1090 Vienna, AustriaDivision of Nephrology, Department of Internal Medicine III, Medical University of Vienna, 1090 Vienna, AustriaMetabolic Unit, Institute of Biomedical Engineering, National Research Council, 35127 Padova, ItalyDivision of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, AustriaDivision of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, AustriaBackground. The study aimed to assess whether women with prior gestational diabetes (pGDM), despite maintenance of normal glucose tolerance (NGT) five years after delivery, display metabolic disturbances compared to healthy controls. Methods. 45 pGDM with NGT were compared to 18 women without a history of GDM (CON), matched for age (37.0 ± 4.1 versus 35.2 ± 5.3, P=ns) and BMI (24.3 ± 3.1 versus 23.3 ± 3.3, P=ns). Metabolic parameters were derived from oral and intravenous glucose tolerance tests; furthermore lipid profile, C-reactive protein (CRP), adiponectin, leptin, and glucagon were assessed. Results. Five years postpartum, pGDM had increased glucose concentrations during the OGTT (AUC: 1.12 ± 0.15 versus 1.0 ± 0.12 mol/L * min, P=0.003) and insulin sensitivity was decreased compared to CON (OGIS: 467.2 ± 64.1 versus 510.6 ± 53.1 mL/min * m2, P=0.01). pGDM had lower adiponectin (8.1 ± 2.6 versus 12.6 ± 5.3, P<0.008) but increased waist circumference and CRP compared to CON. Conclusions. Despite diagnosis of normal glucose tolerance, pGDM are characterized by hyperglycemia and insulin resistance compared to healthy controls, accompanied by decreased adiponectin and increased CRP concentrations, thus linking metabolic disturbances to an increased cardiovascular risk in pGDM.http://dx.doi.org/10.1155/2015/342938 |
| spellingShingle | Yvonne Winhofer Andrea Tura Anita Thomas Thomas Prikoszovich Christine Winzer Giovanni Pacini Anton Luger Alexandra Kautzky-Willer Hidden Metabolic Disturbances in Women with Normal Glucose Tolerance Five Years after Gestational Diabetes International Journal of Endocrinology |
| title | Hidden Metabolic Disturbances in Women with Normal Glucose Tolerance Five Years after Gestational Diabetes |
| title_full | Hidden Metabolic Disturbances in Women with Normal Glucose Tolerance Five Years after Gestational Diabetes |
| title_fullStr | Hidden Metabolic Disturbances in Women with Normal Glucose Tolerance Five Years after Gestational Diabetes |
| title_full_unstemmed | Hidden Metabolic Disturbances in Women with Normal Glucose Tolerance Five Years after Gestational Diabetes |
| title_short | Hidden Metabolic Disturbances in Women with Normal Glucose Tolerance Five Years after Gestational Diabetes |
| title_sort | hidden metabolic disturbances in women with normal glucose tolerance five years after gestational diabetes |
| url | http://dx.doi.org/10.1155/2015/342938 |
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