Immunologic profiling of the infant immune response to whole-cell and acellular pertussis vaccines

Immunologic profiling of the infant immune response to whole-cell and acellular pertussis vaccines

Abstract Despite robust antibody responses, immunity induced by acellular pertussis vaccine (DTaP) wanes over time and risk of pertussis seems to be lower in children who receive whole-cell vaccine (DTP) as their first dose. To interrogate the early immunologic response to pertussis vaccine, we enro...

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Main Authors: C. Buddy Creech, Mariana Leguia, Johannes B. Goll, Leigh M. Howard, Antón Vila-Sanjurjo, Sandra Yoder, Diana Juarez, Alejandra Garcia-Glaessner, Casey E. Gelber, Natalia Jimenez-Truque, Sami Cherikh, Ana I. Gil, James E. Crowe, Rubelio Cornejo Cotos, Kathryn M. Edwards, Claudio F. Lanata
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-025-01170-5
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