Sepsis and Pleural Empyema Caused by Streptococcus pyogenes after Influenza A Virus Infection
Streptococcus pyogenes (also referred to as group A streptococci, GAS) causes severe invasive diseases such as bacteremia, necrotizing fasciitis, pneumonia, osteomyelitis, septic arthritis, and toxic shock syndrome in children. However, there are only a few reports on pleural empyema caused by GAS i...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2018/4509847 |
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| author | Fumihiro Ochi Hisamichi Tauchi Toshihiro Jogamoto Hiromitsu Miura Tomozo Moritani Kozo Nagai Eiichi Ishii |
| author_facet | Fumihiro Ochi Hisamichi Tauchi Toshihiro Jogamoto Hiromitsu Miura Tomozo Moritani Kozo Nagai Eiichi Ishii |
| author_sort | Fumihiro Ochi |
| collection | DOAJ |
| description | Streptococcus pyogenes (also referred to as group A streptococci, GAS) causes severe invasive diseases such as bacteremia, necrotizing fasciitis, pneumonia, osteomyelitis, septic arthritis, and toxic shock syndrome in children. However, there are only a few reports on pleural empyema caused by GAS in children. Here, we report the case of a 4-year-old boy who presented with pleural empyema due to GAS after influenza A virus infection. With intravenous antibiotic administration and continuous chest-tube drainage, followed by video-assisted thoracoscopic surgery, his condition improved. During the clinical course, cytokines induced in response to the influenza virus, especially IL-1β and IL-10, were elevated 1 week after influenza A infection, but these decreased as the symptoms improved. Reportedly, the IL-10 production increases during influenza virus-bacteria superinfection. These observations suggest that the immunological mechanisms induced by the influenza virus can play an important role in influencing the susceptibility to secondary bacterial infections, such as GAS, in children. |
| format | Article |
| id | doaj-art-5cc7bb1fda56474699e272cb28e0c55a |
| institution | Kabale University |
| issn | 2090-6803 2090-6811 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pediatrics |
| spelling | doaj-art-5cc7bb1fda56474699e272cb28e0c55a2025-02-03T01:21:15ZengWileyCase Reports in Pediatrics2090-68032090-68112018-01-01201810.1155/2018/45098474509847Sepsis and Pleural Empyema Caused by Streptococcus pyogenes after Influenza A Virus InfectionFumihiro Ochi0Hisamichi Tauchi1Toshihiro Jogamoto2Hiromitsu Miura3Tomozo Moritani4Kozo Nagai5Eiichi Ishii6Department of Pediatrics, Ehime University Graduate School of Medicine, Ehime, Toon, JapanDepartment of Pediatrics, Ehime University Graduate School of Medicine, Ehime, Toon, JapanDepartment of Pediatrics, Ehime University Graduate School of Medicine, Ehime, Toon, JapanDepartment of Pediatrics, Ehime University Graduate School of Medicine, Ehime, Toon, JapanDepartment of Pediatrics, Ehime University Graduate School of Medicine, Ehime, Toon, JapanDepartment of Pediatrics, Ehime University Graduate School of Medicine, Ehime, Toon, JapanDepartment of Pediatrics, Ehime University Graduate School of Medicine, Ehime, Toon, JapanStreptococcus pyogenes (also referred to as group A streptococci, GAS) causes severe invasive diseases such as bacteremia, necrotizing fasciitis, pneumonia, osteomyelitis, septic arthritis, and toxic shock syndrome in children. However, there are only a few reports on pleural empyema caused by GAS in children. Here, we report the case of a 4-year-old boy who presented with pleural empyema due to GAS after influenza A virus infection. With intravenous antibiotic administration and continuous chest-tube drainage, followed by video-assisted thoracoscopic surgery, his condition improved. During the clinical course, cytokines induced in response to the influenza virus, especially IL-1β and IL-10, were elevated 1 week after influenza A infection, but these decreased as the symptoms improved. Reportedly, the IL-10 production increases during influenza virus-bacteria superinfection. These observations suggest that the immunological mechanisms induced by the influenza virus can play an important role in influencing the susceptibility to secondary bacterial infections, such as GAS, in children.http://dx.doi.org/10.1155/2018/4509847 |
| spellingShingle | Fumihiro Ochi Hisamichi Tauchi Toshihiro Jogamoto Hiromitsu Miura Tomozo Moritani Kozo Nagai Eiichi Ishii Sepsis and Pleural Empyema Caused by Streptococcus pyogenes after Influenza A Virus Infection Case Reports in Pediatrics |
| title | Sepsis and Pleural Empyema Caused by Streptococcus pyogenes after Influenza A Virus Infection |
| title_full | Sepsis and Pleural Empyema Caused by Streptococcus pyogenes after Influenza A Virus Infection |
| title_fullStr | Sepsis and Pleural Empyema Caused by Streptococcus pyogenes after Influenza A Virus Infection |
| title_full_unstemmed | Sepsis and Pleural Empyema Caused by Streptococcus pyogenes after Influenza A Virus Infection |
| title_short | Sepsis and Pleural Empyema Caused by Streptococcus pyogenes after Influenza A Virus Infection |
| title_sort | sepsis and pleural empyema caused by streptococcus pyogenes after influenza a virus infection |
| url | http://dx.doi.org/10.1155/2018/4509847 |
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