Leptin Promotes Glioblastoma
The hormone leptin has a variety of functions. Originally known for its role in satiety and weight loss, leptin more recently has been shown to augment tumor growth in a variety of cancers. Within gliomas, there is a correlation between tumor grade and tumor expression of leptin and its receptor. Th...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Neurology Research International |
| Online Access: | http://dx.doi.org/10.1155/2012/870807 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832554678134505472 |
|---|---|
| author | Johnathan E. Lawrence Nicholas J. Cook Richard A. Rovin Robert J. Winn |
| author_facet | Johnathan E. Lawrence Nicholas J. Cook Richard A. Rovin Robert J. Winn |
| author_sort | Johnathan E. Lawrence |
| collection | DOAJ |
| description | The hormone leptin has a variety of functions. Originally known for its role in satiety and weight loss, leptin more recently has been shown to augment tumor growth in a variety of cancers. Within gliomas, there is a correlation between tumor grade and tumor expression of leptin and its receptor. This suggests that autocrine signaling within the tumor microenvironment may promote the growth of high-grade gliomas. Leptin does this through stimulation of cellular pathways that are also advantageous for tumor growth and recurrence: antiapoptosis, proliferation, angiogenesis, and migration. Conversely, a loss of leptin expression attenuates tumor growth. In animal models of colon cancer and melanoma, a decline in the expression and secretion of leptin resulted in a reduction of tumor growth. In these models, positive mental stimulation through environmental enrichment decreased leptin secretion and improved tumor outcome. This review explores the link between leptin and glioblastoma. |
| format | Article |
| id | doaj-art-5cc750009fa1490da20e5491e58ccd7b |
| institution | Kabale University |
| issn | 2090-1852 2090-1860 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neurology Research International |
| spelling | doaj-art-5cc750009fa1490da20e5491e58ccd7b2025-02-03T05:50:51ZengWileyNeurology Research International2090-18522090-18602012-01-01201210.1155/2012/870807870807Leptin Promotes GlioblastomaJohnathan E. Lawrence0Nicholas J. Cook1Richard A. Rovin2Robert J. Winn3Biology Department, Northern Michigan University (NMU), Marquette, MI 49855, USABiology Department, Northern Michigan University (NMU), Marquette, MI 49855, USAUpper Michigan Brain Tumor Center, NMU and Marquette General Hospital, Marquette, MI 49855, USABiology Department, Northern Michigan University (NMU), Marquette, MI 49855, USAThe hormone leptin has a variety of functions. Originally known for its role in satiety and weight loss, leptin more recently has been shown to augment tumor growth in a variety of cancers. Within gliomas, there is a correlation between tumor grade and tumor expression of leptin and its receptor. This suggests that autocrine signaling within the tumor microenvironment may promote the growth of high-grade gliomas. Leptin does this through stimulation of cellular pathways that are also advantageous for tumor growth and recurrence: antiapoptosis, proliferation, angiogenesis, and migration. Conversely, a loss of leptin expression attenuates tumor growth. In animal models of colon cancer and melanoma, a decline in the expression and secretion of leptin resulted in a reduction of tumor growth. In these models, positive mental stimulation through environmental enrichment decreased leptin secretion and improved tumor outcome. This review explores the link between leptin and glioblastoma.http://dx.doi.org/10.1155/2012/870807 |
| spellingShingle | Johnathan E. Lawrence Nicholas J. Cook Richard A. Rovin Robert J. Winn Leptin Promotes Glioblastoma Neurology Research International |
| title | Leptin Promotes Glioblastoma |
| title_full | Leptin Promotes Glioblastoma |
| title_fullStr | Leptin Promotes Glioblastoma |
| title_full_unstemmed | Leptin Promotes Glioblastoma |
| title_short | Leptin Promotes Glioblastoma |
| title_sort | leptin promotes glioblastoma |
| url | http://dx.doi.org/10.1155/2012/870807 |
| work_keys_str_mv | AT johnathanelawrence leptinpromotesglioblastoma AT nicholasjcook leptinpromotesglioblastoma AT richardarovin leptinpromotesglioblastoma AT robertjwinn leptinpromotesglioblastoma |