TrkB Receptor Antagonism Enhances Insulin Secretion and Increases Pancreatic Islet Size in Rats Fed a Cafeteria-Style Diet
<b>Background:</b> In recent years, the role of neurotrophins and their receptors in peripheral tissues has been of great interest. At a metabolic level, the brain-derived neurotrophic factor (BDNF) and its receptor trkB have been reported to participate in insulin secretion from the pan...
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MDPI AG
2025-01-01
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| author | Jorge Agustín Velasco-Gutierrez Elena Roces de Alvarez-Buylla Sergio Montero Alejandrina Rodríguez-Hernández Saraí Limón Miranda Karmina Martínez-Santillan María del Rosario Álvarez-Valadez Mónica Lemus Alejandra Flores-Silva Adolfo Virgen-Ortiz |
| author_facet | Jorge Agustín Velasco-Gutierrez Elena Roces de Alvarez-Buylla Sergio Montero Alejandrina Rodríguez-Hernández Saraí Limón Miranda Karmina Martínez-Santillan María del Rosario Álvarez-Valadez Mónica Lemus Alejandra Flores-Silva Adolfo Virgen-Ortiz |
| author_sort | Jorge Agustín Velasco-Gutierrez |
| collection | DOAJ |
| description | <b>Background:</b> In recent years, the role of neurotrophins and their receptors in peripheral tissues has been of great interest. At a metabolic level, the brain-derived neurotrophic factor (BDNF) and its receptor trkB have been reported to participate in insulin secretion from the pancreas in response to increases in circulating blood glucose. <b>Objetive:</b> To determines the role of the BDNF-trkB pathway in insulin secretion and pancreatic morphology in rats fed a cafeteria-style diet for 16 weeks. <b>Methods:</b> For the study, male rats of the Wistar strain were divided into three groups as follows: (1) control group (standard diet), (2) CAF group (cafeteria-style diet) and (3) CAF group treated with ANA-12 (TrkB receptor antagonist). After 4 months of intervention, the glucose and insulin tolerance curves, serum insulin levels, body fat and hematoxylin-eosin staining pancreas were evaluated. <b>Results:</b> The results showed that the cafeteria-style diet induced an increase in the amount of body fat, alterations in the glucose tolerance curve, increased insulin circulation levels, increased HOMA indices and increased pancreatic islet size. The antagonism of the trkB receptor in the rats fed a cafeteria-style diet enhanced some effects such as the accumulation of body fat and insulin secretion and induced a greater increase in the pancreas islet size. <b>Conclusions:</b> Under conditions of cafeteria-style diet-induced obesity, the antagonism of the BDNF-trkB pathway had no enhanced effect on the increase in insulin secretion or pancreatic islet size. |
| format | Article |
| id | doaj-art-5caa45748cf34f67bc40ea64791f9515 |
| institution | Kabale University |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| series | Biomedicines |
| spelling | doaj-art-5caa45748cf34f67bc40ea64791f95152025-01-24T13:24:06ZengMDPI AGBiomedicines2227-90592025-01-0113112610.3390/biomedicines13010126TrkB Receptor Antagonism Enhances Insulin Secretion and Increases Pancreatic Islet Size in Rats Fed a Cafeteria-Style DietJorge Agustín Velasco-Gutierrez0Elena Roces de Alvarez-Buylla1Sergio Montero2Alejandrina Rodríguez-Hernández3Saraí Limón Miranda4Karmina Martínez-Santillan5María del Rosario Álvarez-Valadez6Mónica Lemus7Alejandra Flores-Silva8Adolfo Virgen-Ortiz9Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima 28045, Colima, MexicoCentro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima 28045, Colima, MexicoCentro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima 28045, Colima, MexicoFacultad de Medicina, Universidad de Colima, Colima 28040, Colima, MexicoFacultad Interdisciplinaria de Ciencias Biológicas y de Salud, Departamento de Ciencias Químico Biológicas y Agropecuarias, Unidad Regional Sur, Universidad de Sonora, Navojoa 85800, Sonora, MexicoCentro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima 28045, Colima, MexicoCentro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima 28045, Colima, MexicoCentro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima 28045, Colima, MexicoCentro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima 28045, Colima, MexicoCentro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima 28045, Colima, Mexico<b>Background:</b> In recent years, the role of neurotrophins and their receptors in peripheral tissues has been of great interest. At a metabolic level, the brain-derived neurotrophic factor (BDNF) and its receptor trkB have been reported to participate in insulin secretion from the pancreas in response to increases in circulating blood glucose. <b>Objetive:</b> To determines the role of the BDNF-trkB pathway in insulin secretion and pancreatic morphology in rats fed a cafeteria-style diet for 16 weeks. <b>Methods:</b> For the study, male rats of the Wistar strain were divided into three groups as follows: (1) control group (standard diet), (2) CAF group (cafeteria-style diet) and (3) CAF group treated with ANA-12 (TrkB receptor antagonist). After 4 months of intervention, the glucose and insulin tolerance curves, serum insulin levels, body fat and hematoxylin-eosin staining pancreas were evaluated. <b>Results:</b> The results showed that the cafeteria-style diet induced an increase in the amount of body fat, alterations in the glucose tolerance curve, increased insulin circulation levels, increased HOMA indices and increased pancreatic islet size. The antagonism of the trkB receptor in the rats fed a cafeteria-style diet enhanced some effects such as the accumulation of body fat and insulin secretion and induced a greater increase in the pancreas islet size. <b>Conclusions:</b> Under conditions of cafeteria-style diet-induced obesity, the antagonism of the BDNF-trkB pathway had no enhanced effect on the increase in insulin secretion or pancreatic islet size.https://www.mdpi.com/2227-9059/13/1/126cafeteria-style dietBNDF-trkB pathwayneurotrophinspancreasinsulinmetabolic syndrome |
| spellingShingle | Jorge Agustín Velasco-Gutierrez Elena Roces de Alvarez-Buylla Sergio Montero Alejandrina Rodríguez-Hernández Saraí Limón Miranda Karmina Martínez-Santillan María del Rosario Álvarez-Valadez Mónica Lemus Alejandra Flores-Silva Adolfo Virgen-Ortiz TrkB Receptor Antagonism Enhances Insulin Secretion and Increases Pancreatic Islet Size in Rats Fed a Cafeteria-Style Diet Biomedicines cafeteria-style diet BNDF-trkB pathway neurotrophins pancreas insulin metabolic syndrome |
| title | TrkB Receptor Antagonism Enhances Insulin Secretion and Increases Pancreatic Islet Size in Rats Fed a Cafeteria-Style Diet |
| title_full | TrkB Receptor Antagonism Enhances Insulin Secretion and Increases Pancreatic Islet Size in Rats Fed a Cafeteria-Style Diet |
| title_fullStr | TrkB Receptor Antagonism Enhances Insulin Secretion and Increases Pancreatic Islet Size in Rats Fed a Cafeteria-Style Diet |
| title_full_unstemmed | TrkB Receptor Antagonism Enhances Insulin Secretion and Increases Pancreatic Islet Size in Rats Fed a Cafeteria-Style Diet |
| title_short | TrkB Receptor Antagonism Enhances Insulin Secretion and Increases Pancreatic Islet Size in Rats Fed a Cafeteria-Style Diet |
| title_sort | trkb receptor antagonism enhances insulin secretion and increases pancreatic islet size in rats fed a cafeteria style diet |
| topic | cafeteria-style diet BNDF-trkB pathway neurotrophins pancreas insulin metabolic syndrome |
| url | https://www.mdpi.com/2227-9059/13/1/126 |
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