Disribution kinetics of cardioprotector ALM-802 in rat organs and tissues
The distribution kinetics of a compound with cardioprotective activity, N1-(2,3,4-trimethoxybenzyl)-N2-{2-[(2,3,4-trimethoxybenzyl)amino] ethyl}-1,2-ethanediamine (ALM-802) in rat tissues and organs after single intragastric administration at a dose of 100 mg/kg. The values of ALM-802 tissue availab...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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LLC “Publisher OKI”
2022-07-01
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| Series: | Фармакокинетика и Фармакодинамика |
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| Online Access: | https://www.pharmacokinetica.ru/jour/article/view/314 |
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| author | O. Yu. Kravtsova G. B. Kolyvanov A. A. Litvin P. O. Bochkov V. P. Zherdev |
| author_facet | O. Yu. Kravtsova G. B. Kolyvanov A. A. Litvin P. O. Bochkov V. P. Zherdev |
| author_sort | O. Yu. Kravtsova |
| collection | DOAJ |
| description | The distribution kinetics of a compound with cardioprotective activity, N1-(2,3,4-trimethoxybenzyl)-N2-{2-[(2,3,4-trimethoxybenzyl)amino] ethyl}-1,2-ethanediamine (ALM-802) in rat tissues and organs after single intragastric administration at a dose of 100 mg/kg. The values of ALM-802 tissue availability were determined. Tissue availability of ALM-802 falls in a row: kidneys→liver→heart→spleen→skeletal muscle→brain (129.3; 27.2; 20.9; 15.3; 5.9 and 0.3, respectively). It was found that ALM-802 is excreted from the body rather slowly: kel values ranged from 0.0252 to 0.0885 h–1, MRT values were 7.6–59.3 h. |
| format | Article |
| id | doaj-art-5ca71ab2babf4e178b06dbb833a39cc2 |
| institution | DOAJ |
| issn | 2587-7836 2686-8830 |
| language | Russian |
| publishDate | 2022-07-01 |
| publisher | LLC “Publisher OKI” |
| record_format | Article |
| series | Фармакокинетика и Фармакодинамика |
| spelling | doaj-art-5ca71ab2babf4e178b06dbb833a39cc22025-08-20T02:49:52ZrusLLC “Publisher OKI”Фармакокинетика и Фармакодинамика2587-78362686-88302022-07-0102172210.37489/2587-7836-2022-2-17-22300Disribution kinetics of cardioprotector ALM-802 in rat organs and tissuesO. Yu. Kravtsova0G. B. Kolyvanov1A. A. Litvin2P. O. Bochkov3V. P. Zherdev4FSBI “Zakusov Institute of Pharmacology”FSBI “Zakusov Institute of Pharmacology”FSBI “Zakusov Institute of Pharmacology”FSBI “Zakusov Institute of Pharmacology”FSBI “Zakusov Institute of Pharmacology”The distribution kinetics of a compound with cardioprotective activity, N1-(2,3,4-trimethoxybenzyl)-N2-{2-[(2,3,4-trimethoxybenzyl)amino] ethyl}-1,2-ethanediamine (ALM-802) in rat tissues and organs after single intragastric administration at a dose of 100 mg/kg. The values of ALM-802 tissue availability were determined. Tissue availability of ALM-802 falls in a row: kidneys→liver→heart→spleen→skeletal muscle→brain (129.3; 27.2; 20.9; 15.3; 5.9 and 0.3, respectively). It was found that ALM-802 is excreted from the body rather slowly: kel values ranged from 0.0252 to 0.0885 h–1, MRT values were 7.6–59.3 h.https://www.pharmacokinetica.ru/jour/article/view/314cardioprotectoralm-802pharmacokineticstissue availabilityhplc/mass- spectrometry |
| spellingShingle | O. Yu. Kravtsova G. B. Kolyvanov A. A. Litvin P. O. Bochkov V. P. Zherdev Disribution kinetics of cardioprotector ALM-802 in rat organs and tissues Фармакокинетика и Фармакодинамика cardioprotector alm-802 pharmacokinetics tissue availability hplc/mass- spectrometry |
| title | Disribution kinetics of cardioprotector ALM-802 in rat organs and tissues |
| title_full | Disribution kinetics of cardioprotector ALM-802 in rat organs and tissues |
| title_fullStr | Disribution kinetics of cardioprotector ALM-802 in rat organs and tissues |
| title_full_unstemmed | Disribution kinetics of cardioprotector ALM-802 in rat organs and tissues |
| title_short | Disribution kinetics of cardioprotector ALM-802 in rat organs and tissues |
| title_sort | disribution kinetics of cardioprotector alm 802 in rat organs and tissues |
| topic | cardioprotector alm-802 pharmacokinetics tissue availability hplc/mass- spectrometry |
| url | https://www.pharmacokinetica.ru/jour/article/view/314 |
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