HCC Heterogeneity: Molecular Pathogenesis and Clinical Implications
Background: Hepatocellular carcinoma (HCC) poses a major challenge because of the extreme variability of the clinical outcome, which makes it difficult to properly stage the disease and thereby estimate the prognosis. There is growing evidence that this heterogeneous clinical behavior is attributabl...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2009-01-01
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| Series: | Cellular Oncology |
| Online Access: | http://dx.doi.org/10.3233/CLO-2009-0473 |
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| _version_ | 1832565165908819968 |
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| author | Emilia Fransvea Angelo Paradiso Salvatore Antonaci Gianluigi Giannelli |
| author_facet | Emilia Fransvea Angelo Paradiso Salvatore Antonaci Gianluigi Giannelli |
| author_sort | Emilia Fransvea |
| collection | DOAJ |
| description | Background: Hepatocellular carcinoma (HCC) poses a major challenge because of the extreme variability of the clinical outcome, which makes it difficult to properly stage the disease and thereby estimate the prognosis. There is growing evidence that this heterogeneous clinical behavior is attributable to several different biological pathways. A novel approach to mapping these differences is by investigating the epigenetics associated with certain clinical aspects. |
| format | Article |
| id | doaj-art-5ca561749df3490db86a20c90e4ca3dd |
| institution | Kabale University |
| issn | 1570-5870 1875-8606 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cellular Oncology |
| spelling | doaj-art-5ca561749df3490db86a20c90e4ca3dd2025-02-03T01:09:10ZengWileyCellular Oncology1570-58701875-86062009-01-0131322723310.3233/CLO-2009-0473HCC Heterogeneity: Molecular Pathogenesis and Clinical ImplicationsEmilia Fransvea0Angelo Paradiso1Salvatore Antonaci2Gianluigi Giannelli3Department of Internal Medicine, Immunology, and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Bari, ItalyClinical Experimental Oncology Laboratory, National Cancer Institute, Bari, ItalyDepartment of Internal Medicine, Immunology, and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Bari, ItalyDepartment of Internal Medicine, Immunology, and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Bari, ItalyBackground: Hepatocellular carcinoma (HCC) poses a major challenge because of the extreme variability of the clinical outcome, which makes it difficult to properly stage the disease and thereby estimate the prognosis. There is growing evidence that this heterogeneous clinical behavior is attributable to several different biological pathways. A novel approach to mapping these differences is by investigating the epigenetics associated with certain clinical aspects.http://dx.doi.org/10.3233/CLO-2009-0473 |
| spellingShingle | Emilia Fransvea Angelo Paradiso Salvatore Antonaci Gianluigi Giannelli HCC Heterogeneity: Molecular Pathogenesis and Clinical Implications Cellular Oncology |
| title | HCC Heterogeneity: Molecular Pathogenesis and Clinical Implications |
| title_full | HCC Heterogeneity: Molecular Pathogenesis and Clinical Implications |
| title_fullStr | HCC Heterogeneity: Molecular Pathogenesis and Clinical Implications |
| title_full_unstemmed | HCC Heterogeneity: Molecular Pathogenesis and Clinical Implications |
| title_short | HCC Heterogeneity: Molecular Pathogenesis and Clinical Implications |
| title_sort | hcc heterogeneity molecular pathogenesis and clinical implications |
| url | http://dx.doi.org/10.3233/CLO-2009-0473 |
| work_keys_str_mv | AT emiliafransvea hccheterogeneitymolecularpathogenesisandclinicalimplications AT angeloparadiso hccheterogeneitymolecularpathogenesisandclinicalimplications AT salvatoreantonaci hccheterogeneitymolecularpathogenesisandclinicalimplications AT gianluigigiannelli hccheterogeneitymolecularpathogenesisandclinicalimplications |