HCC Heterogeneity: Molecular Pathogenesis and Clinical Implications
Background: Hepatocellular carcinoma (HCC) poses a major challenge because of the extreme variability of the clinical outcome, which makes it difficult to properly stage the disease and thereby estimate the prognosis. There is growing evidence that this heterogeneous clinical behavior is attributabl...
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Main Authors: | , , , |
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Format: | Article |
Language: | English |
Published: |
Wiley
2009-01-01
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Series: | Cellular Oncology |
Online Access: | http://dx.doi.org/10.3233/CLO-2009-0473 |
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Summary: | Background: Hepatocellular carcinoma (HCC) poses a major challenge because of the extreme variability of the clinical outcome, which makes it difficult to properly stage the disease and thereby estimate the prognosis. There is growing evidence that this heterogeneous clinical behavior is attributable to several different biological pathways. A novel approach to mapping these differences is by investigating the epigenetics associated with certain clinical aspects. |
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ISSN: | 1570-5870 1875-8606 |