The Role of PPARγ in the Transcriptional Control by Agonists and Antagonists
In recent years, peroxisome proliferator-activated receptor gamma (PPARγ) has been reported to be a target for the treatment of type II diabetes. Furthermore, it has received attention for its therapeutic potential in many other human diseases, including atherosclerosis, obesity, and cancers. Recent...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2012/362361 |
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| author | Tamotsu Tsukahara |
| author_facet | Tamotsu Tsukahara |
| author_sort | Tamotsu Tsukahara |
| collection | DOAJ |
| description | In recent years, peroxisome proliferator-activated receptor gamma (PPARγ) has been reported to be a target for the treatment of type II diabetes. Furthermore, it has received attention for its therapeutic potential in many other human diseases, including atherosclerosis, obesity, and cancers. Recent studies have provided evidence that the endogenously produced PPARγ antagonist, 2,3-cyclic phosphatidic acid (cPA), which is similar in structure to lysophosphatidic acid (LPA), inhibits cancer cell invasion and metastasis in vitro and in vivo. We recently observed that cPA negatively regulates PPARγ function by stabilizing the binding of the corepressor protein, silencing mediator of retinoic acid and thyroid hormone receptor. We also showed that cPA prevents neointima formation, adipocyte differentiation, lipid accumulation, and upregulation of PPARγ target gene transcription. We then analyzed the molecular mechanism of cPA's action on PPARγ. In this paper, we summarize the current knowledge on the mechanism of PPARγ-mediated transcriptional activity and transcriptional repression in response to novel lipid-derived ligands, such as cPA. |
| format | Article |
| id | doaj-art-5c9498f8e4094564a39e0e460ca4e59c |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-5c9498f8e4094564a39e0e460ca4e59c2025-02-03T06:08:16ZengWileyPPAR Research1687-47571687-47652012-01-01201210.1155/2012/362361362361The Role of PPARγ in the Transcriptional Control by Agonists and AntagonistsTamotsu Tsukahara0Department of Integrative Physiology and Bio-System Control, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, JapanIn recent years, peroxisome proliferator-activated receptor gamma (PPARγ) has been reported to be a target for the treatment of type II diabetes. Furthermore, it has received attention for its therapeutic potential in many other human diseases, including atherosclerosis, obesity, and cancers. Recent studies have provided evidence that the endogenously produced PPARγ antagonist, 2,3-cyclic phosphatidic acid (cPA), which is similar in structure to lysophosphatidic acid (LPA), inhibits cancer cell invasion and metastasis in vitro and in vivo. We recently observed that cPA negatively regulates PPARγ function by stabilizing the binding of the corepressor protein, silencing mediator of retinoic acid and thyroid hormone receptor. We also showed that cPA prevents neointima formation, adipocyte differentiation, lipid accumulation, and upregulation of PPARγ target gene transcription. We then analyzed the molecular mechanism of cPA's action on PPARγ. In this paper, we summarize the current knowledge on the mechanism of PPARγ-mediated transcriptional activity and transcriptional repression in response to novel lipid-derived ligands, such as cPA.http://dx.doi.org/10.1155/2012/362361 |
| spellingShingle | Tamotsu Tsukahara The Role of PPARγ in the Transcriptional Control by Agonists and Antagonists PPAR Research |
| title | The Role of PPARγ in the Transcriptional Control by Agonists and Antagonists |
| title_full | The Role of PPARγ in the Transcriptional Control by Agonists and Antagonists |
| title_fullStr | The Role of PPARγ in the Transcriptional Control by Agonists and Antagonists |
| title_full_unstemmed | The Role of PPARγ in the Transcriptional Control by Agonists and Antagonists |
| title_short | The Role of PPARγ in the Transcriptional Control by Agonists and Antagonists |
| title_sort | role of pparγ in the transcriptional control by agonists and antagonists |
| url | http://dx.doi.org/10.1155/2012/362361 |
| work_keys_str_mv | AT tamotsutsukahara theroleofpparginthetranscriptionalcontrolbyagonistsandantagonists AT tamotsutsukahara roleofpparginthetranscriptionalcontrolbyagonistsandantagonists |