Association of fatty acid desaturase 2 gene polymorphism (rs28456) with susceptibility to bipolar disorder in the Turkish population: A case-control study
The FADS2 gene encodes a key, rate-limiting enzyme involved in polyunsaturated fatty acid (PUFA) metabolism. Recent studies suggest that changes in plasma PUFA levels can lead to disruptions in the neurotransmission system and increase the risk of mood disorders. FADS2 variations may contribute to t...
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University of Belgrade, University of Novi Sad
2024-01-01
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| Series: | Archives of Biological Sciences |
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| Online Access: | https://doiserbia.nb.rs/img/doi/0354-4664/2024/0354-46642400029P.pdf |
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| author | Pirim Dilek Gümüş Ceren Boztepe Esra Akdağ Emine Merve Şirin Hande |
| author_facet | Pirim Dilek Gümüş Ceren Boztepe Esra Akdağ Emine Merve Şirin Hande |
| author_sort | Pirim Dilek |
| collection | DOAJ |
| description | The FADS2 gene encodes a key, rate-limiting enzyme involved in polyunsaturated fatty acid (PUFA) metabolism. Recent studies suggest that changes in plasma PUFA levels can lead to disruptions in the neurotransmission system and increase the risk of mood disorders. FADS2 variations may contribute to the individual risk of developing bipolar disorder (BD). We investigated the association of regulatory FADS2 rs28456 with BD in the Turkish population. We performed TaqMan genotyping on 100 patients with BD and 91 healthy controls. Our results did not show significantly different genotype or allele frequencies of rs28456 in the BD cases compared to controls. However, we stratified the cases based on family history, which revealed that minor rs28456-G was observed more frequently (P=0.056) in cases without a family history of psychiatric illness compared to those with a family history of psychiatric illness. A marginally significant difference in the distribution of the “G” allele (P=0.053) between male patients and healthy males without a family history was observed. Our findings did not provide strong evidence supporting the reported association between rs28456 and BD, yet they point to its potential gender-specific effect, which requires further investigation. Future studies are necessary to explore the impact of FADS2 variations on BD risk in larger study groups, considering their potential interaction with non-inherited risk factors. |
| format | Article |
| id | doaj-art-5c873ab5ddd2439a8931b5fafae6b96c |
| institution | Kabale University |
| issn | 0354-4664 1821-4339 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | University of Belgrade, University of Novi Sad |
| record_format | Article |
| series | Archives of Biological Sciences |
| spelling | doaj-art-5c873ab5ddd2439a8931b5fafae6b96c2025-01-30T06:38:39ZengUniversity of Belgrade, University of Novi SadArchives of Biological Sciences0354-46641821-43392024-01-0176438739710.2298/ABS240904029P0354-46642400029PAssociation of fatty acid desaturase 2 gene polymorphism (rs28456) with susceptibility to bipolar disorder in the Turkish population: A case-control studyPirim Dilek0https://orcid.org/0000-0002-0522-9432Gümüş Ceren1https://orcid.org/0009-0003-7778-5133Boztepe Esra2https://orcid.org/0009-0007-9921-8091Akdağ Emine Merve3https://orcid.org/0000-0003-2866-7790Şirin Hande4https://orcid.org/0000-0002-2159-523XBursa Uludag University, Faculty of Arts & Science, Department of Molecular Biology and Genetics, Bursa, Türkiye + Bursa Uludag University, Institute of Health Sciences, Department of Translational Medicine, Bursa, Türkiye + Bursa Uludag University, Institute of Natural and Applied Science, Department of Molecular Biology and Genetics, Bursa, TürkiyeBursa Uludag University, Institute of Health Sciences, Department of Translational Medicine, Bursa, TürkiyeBursa Uludag University, Institute of Natural and Applied Science, Department of Molecular Biology and Genetics, Bursa, TürkiyeDepartment of Psychiatry, Bursa Yüksek Ihtisas Training and Research Hospital, Bursa, TürkiyeDepartment of Child and Adolescent Psychiatry, Bursa Yüksek Ihtisas Training and Research Hospital, Bursa, TürkiyeThe FADS2 gene encodes a key, rate-limiting enzyme involved in polyunsaturated fatty acid (PUFA) metabolism. Recent studies suggest that changes in plasma PUFA levels can lead to disruptions in the neurotransmission system and increase the risk of mood disorders. FADS2 variations may contribute to the individual risk of developing bipolar disorder (BD). We investigated the association of regulatory FADS2 rs28456 with BD in the Turkish population. We performed TaqMan genotyping on 100 patients with BD and 91 healthy controls. Our results did not show significantly different genotype or allele frequencies of rs28456 in the BD cases compared to controls. However, we stratified the cases based on family history, which revealed that minor rs28456-G was observed more frequently (P=0.056) in cases without a family history of psychiatric illness compared to those with a family history of psychiatric illness. A marginally significant difference in the distribution of the “G” allele (P=0.053) between male patients and healthy males without a family history was observed. Our findings did not provide strong evidence supporting the reported association between rs28456 and BD, yet they point to its potential gender-specific effect, which requires further investigation. Future studies are necessary to explore the impact of FADS2 variations on BD risk in larger study groups, considering their potential interaction with non-inherited risk factors.https://doiserbia.nb.rs/img/doi/0354-4664/2024/0354-46642400029P.pdffatty acid desaturase 2 (fads2)bipolar disorderrs28456polyunsaturated fatty acidspufa |
| spellingShingle | Pirim Dilek Gümüş Ceren Boztepe Esra Akdağ Emine Merve Şirin Hande Association of fatty acid desaturase 2 gene polymorphism (rs28456) with susceptibility to bipolar disorder in the Turkish population: A case-control study Archives of Biological Sciences fatty acid desaturase 2 (fads2) bipolar disorder rs28456 polyunsaturated fatty acids pufa |
| title | Association of fatty acid desaturase 2 gene polymorphism (rs28456) with susceptibility to bipolar disorder in the Turkish population: A case-control study |
| title_full | Association of fatty acid desaturase 2 gene polymorphism (rs28456) with susceptibility to bipolar disorder in the Turkish population: A case-control study |
| title_fullStr | Association of fatty acid desaturase 2 gene polymorphism (rs28456) with susceptibility to bipolar disorder in the Turkish population: A case-control study |
| title_full_unstemmed | Association of fatty acid desaturase 2 gene polymorphism (rs28456) with susceptibility to bipolar disorder in the Turkish population: A case-control study |
| title_short | Association of fatty acid desaturase 2 gene polymorphism (rs28456) with susceptibility to bipolar disorder in the Turkish population: A case-control study |
| title_sort | association of fatty acid desaturase 2 gene polymorphism rs28456 with susceptibility to bipolar disorder in the turkish population a case control study |
| topic | fatty acid desaturase 2 (fads2) bipolar disorder rs28456 polyunsaturated fatty acids pufa |
| url | https://doiserbia.nb.rs/img/doi/0354-4664/2024/0354-46642400029P.pdf |
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