Studies on the Interleukin-10 Gene in Animal Models of Colitis
Cytokines play a role in the inflammatory process in colitis and may have therapeutic potential. Interleukin-10 (IL-10) has both immunomodulatory and anti-inflammatory properties. IL-10-deficient mice develop intestinal inflammation with increased tissue levels of other cytokines, including tumour n...
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| Format: | Article |
| Language: | English |
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Wiley
2001-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2001/303729 |
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| _version_ | 1832549853945659392 |
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| author | Hugh J Freeman |
| author_facet | Hugh J Freeman |
| author_sort | Hugh J Freeman |
| collection | DOAJ |
| description | Cytokines play a role in the inflammatory process in colitis and may have therapeutic potential. Interleukin-10 (IL-10) has both immunomodulatory and anti-inflammatory properties. IL-10-deficient mice develop intestinal inflammation with increased tissue levels of other cytokines, including tumour necrosis factor-alpha. In patients with inflammatory bowel disease, impaired IL-10 production by lamina propria T cells occurs and human recombinant IL-10 improves clinical parameters in inflammatory bowel disease (eg, Crohn's disease). There seem to be conflicting results in differing animal models, and the timing of administration of IL-10 relative to onset of colitis may be critical, possibly due to rapid clearance of IL-10. Interestingly, in IL-10 gene-deficient mice raised in germ-free conditions, the intestinal inflammatory changes normally observed in conventional nongerm-free conditions are not detected, suggesting a role for luminal bacteria in the pathogenesis of the inflammatory process. |
| format | Article |
| id | doaj-art-5c6bc5ea15dd4795809ca1b4c367cf99 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2001-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-5c6bc5ea15dd4795809ca1b4c367cf992025-02-03T06:08:23ZengWileyCanadian Journal of Gastroenterology0835-79002001-01-0115855755810.1155/2001/303729Studies on the Interleukin-10 Gene in Animal Models of ColitisHugh J Freeman0Department of Medicine (Gastroenterology), ACU F-137, University of British Columbia Hospital, 2211 Wesbrook Mall, Vancouver, British Columbia, CanadaCytokines play a role in the inflammatory process in colitis and may have therapeutic potential. Interleukin-10 (IL-10) has both immunomodulatory and anti-inflammatory properties. IL-10-deficient mice develop intestinal inflammation with increased tissue levels of other cytokines, including tumour necrosis factor-alpha. In patients with inflammatory bowel disease, impaired IL-10 production by lamina propria T cells occurs and human recombinant IL-10 improves clinical parameters in inflammatory bowel disease (eg, Crohn's disease). There seem to be conflicting results in differing animal models, and the timing of administration of IL-10 relative to onset of colitis may be critical, possibly due to rapid clearance of IL-10. Interestingly, in IL-10 gene-deficient mice raised in germ-free conditions, the intestinal inflammatory changes normally observed in conventional nongerm-free conditions are not detected, suggesting a role for luminal bacteria in the pathogenesis of the inflammatory process.http://dx.doi.org/10.1155/2001/303729 |
| spellingShingle | Hugh J Freeman Studies on the Interleukin-10 Gene in Animal Models of Colitis Canadian Journal of Gastroenterology |
| title | Studies on the Interleukin-10 Gene in Animal Models of Colitis |
| title_full | Studies on the Interleukin-10 Gene in Animal Models of Colitis |
| title_fullStr | Studies on the Interleukin-10 Gene in Animal Models of Colitis |
| title_full_unstemmed | Studies on the Interleukin-10 Gene in Animal Models of Colitis |
| title_short | Studies on the Interleukin-10 Gene in Animal Models of Colitis |
| title_sort | studies on the interleukin 10 gene in animal models of colitis |
| url | http://dx.doi.org/10.1155/2001/303729 |
| work_keys_str_mv | AT hughjfreeman studiesontheinterleukin10geneinanimalmodelsofcolitis |