Application of adoptive cell therapy in malignant melanoma
Abstract Cutaneous melanoma is one of the most aggressive skin cancers originating from skin pigment cells. Patients with advanced melanoma suffer a poor prognosis and generally cannot benefit well from surgical resection and chemo/target therapy due to metastasis and drug resistance. Thus, adoptive...
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| Language: | English |
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BMC
2025-01-01
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| Series: | Journal of Translational Medicine |
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| Online Access: | https://doi.org/10.1186/s12967-025-06093-2 |
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| author | Qianrong Hu Jiangying Xuan Lu Wang Kangjie Shen Zixu Gao Yuhong Zhou Chuanyuan Wei Jianying Gu |
| author_facet | Qianrong Hu Jiangying Xuan Lu Wang Kangjie Shen Zixu Gao Yuhong Zhou Chuanyuan Wei Jianying Gu |
| author_sort | Qianrong Hu |
| collection | DOAJ |
| description | Abstract Cutaneous melanoma is one of the most aggressive skin cancers originating from skin pigment cells. Patients with advanced melanoma suffer a poor prognosis and generally cannot benefit well from surgical resection and chemo/target therapy due to metastasis and drug resistance. Thus, adoptive cell therapy (ACT), employing immune cells with specific tumor-recognizing receptors, has emerged as a promising therapeutic approach to display on-tumor toxicity. This review discusses the application, efficacy, limitations, as well as future prospects of four commonly utilized approaches -including tumor-infiltrating lymphocytes, chimeric antigen receptor (CAR) T cell, engineered T-cell receptor T cells, and chimeric antigen receptor NK cells- in the context of malignant melanoma. |
| format | Article |
| id | doaj-art-5c687ab0d8494851859e8696cbaa5434 |
| institution | Kabale University |
| issn | 1479-5876 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj-art-5c687ab0d8494851859e8696cbaa54342025-01-26T12:50:28ZengBMCJournal of Translational Medicine1479-58762025-01-0123111210.1186/s12967-025-06093-2Application of adoptive cell therapy in malignant melanomaQianrong Hu0Jiangying Xuan1Lu Wang2Kangjie Shen3Zixu Gao4Yuhong Zhou5Chuanyuan Wei6Jianying Gu7Department of Plastic and Reconstructive Surgery, Zhongshan Hospital, Fudan UniversityDepartment of Plastic and Reconstructive Surgery, Zhongshan Hospital, Fudan UniversityDepartment of Plastic and Reconstructive Surgery, Zhongshan Hospital, Fudan UniversityDepartment of Plastic and Reconstructive Surgery, Zhongshan Hospital, Fudan UniversityDepartment of Plastic and Reconstructive Surgery, Zhongshan Hospital, Fudan UniversityDepartment of Medical Oncology, Zhongshan Hospital, Fudan UniversityDepartment of Plastic and Reconstructive Surgery, Zhongshan Hospital, Fudan UniversityDepartment of Plastic and Reconstructive Surgery, Zhongshan Hospital, Fudan UniversityAbstract Cutaneous melanoma is one of the most aggressive skin cancers originating from skin pigment cells. Patients with advanced melanoma suffer a poor prognosis and generally cannot benefit well from surgical resection and chemo/target therapy due to metastasis and drug resistance. Thus, adoptive cell therapy (ACT), employing immune cells with specific tumor-recognizing receptors, has emerged as a promising therapeutic approach to display on-tumor toxicity. This review discusses the application, efficacy, limitations, as well as future prospects of four commonly utilized approaches -including tumor-infiltrating lymphocytes, chimeric antigen receptor (CAR) T cell, engineered T-cell receptor T cells, and chimeric antigen receptor NK cells- in the context of malignant melanoma.https://doi.org/10.1186/s12967-025-06093-2Adoptive Cell TherapyT-cell ReceptorsChimeric Antigen Receptors (CARs)-T cellNatural Killer (NK) CellsTumor-infiltrating LymphocytesMalignant Melanoma |
| spellingShingle | Qianrong Hu Jiangying Xuan Lu Wang Kangjie Shen Zixu Gao Yuhong Zhou Chuanyuan Wei Jianying Gu Application of adoptive cell therapy in malignant melanoma Journal of Translational Medicine Adoptive Cell Therapy T-cell Receptors Chimeric Antigen Receptors (CARs)-T cell Natural Killer (NK) Cells Tumor-infiltrating Lymphocytes Malignant Melanoma |
| title | Application of adoptive cell therapy in malignant melanoma |
| title_full | Application of adoptive cell therapy in malignant melanoma |
| title_fullStr | Application of adoptive cell therapy in malignant melanoma |
| title_full_unstemmed | Application of adoptive cell therapy in malignant melanoma |
| title_short | Application of adoptive cell therapy in malignant melanoma |
| title_sort | application of adoptive cell therapy in malignant melanoma |
| topic | Adoptive Cell Therapy T-cell Receptors Chimeric Antigen Receptors (CARs)-T cell Natural Killer (NK) Cells Tumor-infiltrating Lymphocytes Malignant Melanoma |
| url | https://doi.org/10.1186/s12967-025-06093-2 |
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