Dental problems and oral microbiome alterations in ulcerative colitis
Ulcerative colitis is a chronic disease that has not well-established etiology. The role of microbial dysregulation in its pathogenesis has been recently highlighted. Overall, microbiome alterations concern the reduction of bacterial abundance and diversity, resulting in gut microbiome imbalance neg...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1502605/full |
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| author | Robert Kucharski Robert Kucharski Bartosz Kamil Sobocki Ewa Stachowska Nikola Bulman Leszek Kalinowski Leszek Kalinowski Karolina Kaźmierczak-Siedlecka |
| author_facet | Robert Kucharski Robert Kucharski Bartosz Kamil Sobocki Ewa Stachowska Nikola Bulman Leszek Kalinowski Leszek Kalinowski Karolina Kaźmierczak-Siedlecka |
| author_sort | Robert Kucharski |
| collection | DOAJ |
| description | Ulcerative colitis is a chronic disease that has not well-established etiology. The role of microbial dysregulation in its pathogenesis has been recently highlighted. Overall, microbiome alterations concern the reduction of bacterial abundance and diversity, resulting in gut microbiome imbalance negatively affecting immunological aspects. There is a link between ulcerative colitis and the oral microbiome. The changes of oral microbiome are found at many levels, from gently dysbiotic composition to the presence of the main periodontal microbes. The analysis of oral microbiome can be a part of personalized medicine due to the fact that it is a potential biomarker. Patients with ulcerative colitis may manifest dental symptoms/problems, such as periodontitis (strongly related to the red-complex pathogens—Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, and bacteria belonging to the other complexes, such as Fusobacterium nucleatum and Aggregatibacter actinomycetecomitans), dental caries, oral ulcerations, leukoplakia, halitosis, and others. Notably, the DMFT (Decayed, Missing, Filled Teeth) index is higher in these patients compared to healthy subjects. According to some data, oral lichen planus (which is a disease with an immunological background) can also be observed in ulcerative colitis patients. It seems that deep understanding of ulcerative colitis in association with oral microbiome, immunology, and dental manifestations may be crucial to provide complex treatment from a dental point of view. |
| format | Article |
| id | doaj-art-5c5d30b040704c50bb6866412ce27787 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-5c5d30b040704c50bb6866412ce277872025-02-05T07:32:51ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-02-011610.3389/fimmu.2025.15026051502605Dental problems and oral microbiome alterations in ulcerative colitisRobert Kucharski0Robert Kucharski1Bartosz Kamil Sobocki2Ewa Stachowska3Nikola Bulman4Leszek Kalinowski5Leszek Kalinowski6Karolina Kaźmierczak-Siedlecka7Department of Medical Laboratory Diagnostics – Fahrenheit Biobank BBMRI.pl, Medical University of Gdansk, Gdańsk, PolandNeodentica Dentistry Center, Gdansk, PolandDepartment of Oncology and Radiotherapy, Medical University of Gdansk, Gdańsk, PolandDepartment of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, Szczecin, PolandDepartment of Medical Laboratory Diagnostics – Fahrenheit Biobank BBMRI.pl, Medical University of Gdansk, Gdańsk, PolandDepartment of Medical Laboratory Diagnostics – Fahrenheit Biobank BBMRI.pl, Medical University of Gdansk, Gdańsk, PolandBioTechMed Center, Department of Mechanics of Materials and Structures, Gdansk University of Technology, Gdansk, PolandDepartment of Medical Laboratory Diagnostics – Fahrenheit Biobank BBMRI.pl, Medical University of Gdansk, Gdańsk, PolandUlcerative colitis is a chronic disease that has not well-established etiology. The role of microbial dysregulation in its pathogenesis has been recently highlighted. Overall, microbiome alterations concern the reduction of bacterial abundance and diversity, resulting in gut microbiome imbalance negatively affecting immunological aspects. There is a link between ulcerative colitis and the oral microbiome. The changes of oral microbiome are found at many levels, from gently dysbiotic composition to the presence of the main periodontal microbes. The analysis of oral microbiome can be a part of personalized medicine due to the fact that it is a potential biomarker. Patients with ulcerative colitis may manifest dental symptoms/problems, such as periodontitis (strongly related to the red-complex pathogens—Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, and bacteria belonging to the other complexes, such as Fusobacterium nucleatum and Aggregatibacter actinomycetecomitans), dental caries, oral ulcerations, leukoplakia, halitosis, and others. Notably, the DMFT (Decayed, Missing, Filled Teeth) index is higher in these patients compared to healthy subjects. According to some data, oral lichen planus (which is a disease with an immunological background) can also be observed in ulcerative colitis patients. It seems that deep understanding of ulcerative colitis in association with oral microbiome, immunology, and dental manifestations may be crucial to provide complex treatment from a dental point of view.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1502605/fullulcerative colitisoral microbiomeperiodontitisdental cariesoral ulcerslichen planus |
| spellingShingle | Robert Kucharski Robert Kucharski Bartosz Kamil Sobocki Ewa Stachowska Nikola Bulman Leszek Kalinowski Leszek Kalinowski Karolina Kaźmierczak-Siedlecka Dental problems and oral microbiome alterations in ulcerative colitis Frontiers in Immunology ulcerative colitis oral microbiome periodontitis dental caries oral ulcers lichen planus |
| title | Dental problems and oral microbiome alterations in ulcerative colitis |
| title_full | Dental problems and oral microbiome alterations in ulcerative colitis |
| title_fullStr | Dental problems and oral microbiome alterations in ulcerative colitis |
| title_full_unstemmed | Dental problems and oral microbiome alterations in ulcerative colitis |
| title_short | Dental problems and oral microbiome alterations in ulcerative colitis |
| title_sort | dental problems and oral microbiome alterations in ulcerative colitis |
| topic | ulcerative colitis oral microbiome periodontitis dental caries oral ulcers lichen planus |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1502605/full |
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