Evidence for in vivo resistance against allopurinol in a dog infected with Leishmania infantum by reduction in copy numbers of the S-adenosylmethionine synthetase (METK) gene

Evidence for in vivo resistance against allopurinol in a dog infected with Leishmania infantum by reduction in copy numbers of the S-adenosylmethionine synthetase (METK) gene

Abstract Background In Europe, canine leishmaniasis is commonly caused by Leishmania infantum. Allopurinol is the main drug for long-term management of the disease, and clinical relapses of L. infantum infection treated with this drug are described. Resistance to allopurinol has been demonstrated in...

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Bibliographic Details
Main Authors: Ingo Schäfer, Mathieu Faucher, Yaarit Nachum-Biala, Lluís Ferrer, Marina Carrasco, Alexandra Kehl, Elisabeth Müller, Torsten J. Naucke, Gad Baneth
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Parasites & Vectors
Subjects:
Vector-borne infection
Leishmaniasis
Treatment
Online Access:https://doi.org/10.1186/s13071-024-06583-0
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