Correlation of non-alcoholic fatty liver disease and neurodegenerative disorders
Abstract Non-alcoholic fatty liver disease and neurodegenerative disorders represent significant health challenges worldwide, with shared pathophysiological mechanisms. Evolving data indicates a bidirectional relationship between NAFLD and neurodegenerative disorders, with common risk factors, such...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2024-11-01
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| Series: | Egyptian Liver Journal |
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| Online Access: | https://doi.org/10.1186/s43066-024-00386-9 |
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| author | Pranali A. Jadhav Asha B. Thomas Vinay M. Chopada Prajay V. Bokaria Shivam B. Deokate Pankaj S. Chougule Pruthviraj N. Chavan Sohan S. Chitlange |
| author_facet | Pranali A. Jadhav Asha B. Thomas Vinay M. Chopada Prajay V. Bokaria Shivam B. Deokate Pankaj S. Chougule Pruthviraj N. Chavan Sohan S. Chitlange |
| author_sort | Pranali A. Jadhav |
| collection | DOAJ |
| description | Abstract Non-alcoholic fatty liver disease and neurodegenerative disorders represent significant health challenges worldwide, with shared pathophysiological mechanisms. Evolving data indicates a bidirectional relationship between NAFLD and neurodegenerative disorders, with common risk factors, such as metabolic syndrome, inflammation, oxidative stress, and genetic predisposition, contributing to both conditions. Mechanistic links connecting NAFLD and neurodegeneration include systemic inflammation, dysregulation of the gut-liver-brain axis, and vascular dysfunction. This comprehensive review explores the intricate relationship between NAFLD and neurodegenerative disorders, focusing on shared pathophysiological mechanisms, common risk factors, and emerging therapeutic strategies. Furthermore, it presents evidence of the association between NAFLD and neurodegenerative disorders from clinical studies, underscoring the importance of understanding and addressing these interconnected conditions. A broad understanding of the complex linking between NAFLD and neurodegenerative disorders is essential for the advancement of future therapeutic strategies that can effectively lessen the load of these devastating conditions. By unveiling the shared pathophysiological mechanisms, common risk factors, and interconnected pathways linking NAFLD and neurodegeneration, researchers can identify novel therapeutic targets and interventions aimed at halting disease progression and preserving patient health. |
| format | Article |
| id | doaj-art-5c4eefe1a77c4111a0b1ad6f0bab9ae5 |
| institution | OA Journals |
| issn | 2090-6226 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Liver Journal |
| spelling | doaj-art-5c4eefe1a77c4111a0b1ad6f0bab9ae52025-08-20T02:13:35ZengSpringerOpenEgyptian Liver Journal2090-62262024-11-0114111010.1186/s43066-024-00386-9Correlation of non-alcoholic fatty liver disease and neurodegenerative disordersPranali A. Jadhav0Asha B. Thomas1Vinay M. Chopada2Prajay V. Bokaria3Shivam B. Deokate4Pankaj S. Chougule5Pruthviraj N. Chavan6Sohan S. Chitlange7Department of Pharmaceutical Chemistry, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and ResearchDepartment of Pharmaceutical Chemistry, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and ResearchDepartment of Pharmaceutical Sciences, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and ResearchDepartment of Pharmaceutical Sciences, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and ResearchDepartment of Pharmaceutical Sciences, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and ResearchDepartment of Pharmaceutical Sciences, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and ResearchDepartment of Pharmaceutical Sciences, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and ResearchDepartment of Pharmaceutical Chemistry, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and ResearchAbstract Non-alcoholic fatty liver disease and neurodegenerative disorders represent significant health challenges worldwide, with shared pathophysiological mechanisms. Evolving data indicates a bidirectional relationship between NAFLD and neurodegenerative disorders, with common risk factors, such as metabolic syndrome, inflammation, oxidative stress, and genetic predisposition, contributing to both conditions. Mechanistic links connecting NAFLD and neurodegeneration include systemic inflammation, dysregulation of the gut-liver-brain axis, and vascular dysfunction. This comprehensive review explores the intricate relationship between NAFLD and neurodegenerative disorders, focusing on shared pathophysiological mechanisms, common risk factors, and emerging therapeutic strategies. Furthermore, it presents evidence of the association between NAFLD and neurodegenerative disorders from clinical studies, underscoring the importance of understanding and addressing these interconnected conditions. A broad understanding of the complex linking between NAFLD and neurodegenerative disorders is essential for the advancement of future therapeutic strategies that can effectively lessen the load of these devastating conditions. By unveiling the shared pathophysiological mechanisms, common risk factors, and interconnected pathways linking NAFLD and neurodegeneration, researchers can identify novel therapeutic targets and interventions aimed at halting disease progression and preserving patient health.https://doi.org/10.1186/s43066-024-00386-9NAFLDNeurodegenerative disordersInflammationDyslipidaemiaDysbiosisDementia |
| spellingShingle | Pranali A. Jadhav Asha B. Thomas Vinay M. Chopada Prajay V. Bokaria Shivam B. Deokate Pankaj S. Chougule Pruthviraj N. Chavan Sohan S. Chitlange Correlation of non-alcoholic fatty liver disease and neurodegenerative disorders Egyptian Liver Journal NAFLD Neurodegenerative disorders Inflammation Dyslipidaemia Dysbiosis Dementia |
| title | Correlation of non-alcoholic fatty liver disease and neurodegenerative disorders |
| title_full | Correlation of non-alcoholic fatty liver disease and neurodegenerative disorders |
| title_fullStr | Correlation of non-alcoholic fatty liver disease and neurodegenerative disorders |
| title_full_unstemmed | Correlation of non-alcoholic fatty liver disease and neurodegenerative disorders |
| title_short | Correlation of non-alcoholic fatty liver disease and neurodegenerative disorders |
| title_sort | correlation of non alcoholic fatty liver disease and neurodegenerative disorders |
| topic | NAFLD Neurodegenerative disorders Inflammation Dyslipidaemia Dysbiosis Dementia |
| url | https://doi.org/10.1186/s43066-024-00386-9 |
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