Nociceptive and Neuronal Evaluation of the Sciatic Nerve of Wistar Rats Subjected to Compression Injury and Treated with Resistive Exercise
Background. To investigate the climb stairs resistance exercise on nociception and axonal regeneration in the sciatic nerve of rats. Methods. 24 Wistar rats were divided: control group (CG—no injury), exercise group (EG—no injury with physical exercise), lesion group (LG—injury, but without exercise...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Pain Research and Management |
| Online Access: | http://dx.doi.org/10.1155/2016/6487160 |
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| author | Juliana Sobral Antunes Keli Lovison Jhenifer Karvat Ana Luiza Peretti Lizyana Vieira Guilherme Hideaki Higuchi Rose Meire Costa Brancalhão Lucinéia de Fátima Chasko Ribeiro Gladson Ricardo Flor Bertolini |
| author_facet | Juliana Sobral Antunes Keli Lovison Jhenifer Karvat Ana Luiza Peretti Lizyana Vieira Guilherme Hideaki Higuchi Rose Meire Costa Brancalhão Lucinéia de Fátima Chasko Ribeiro Gladson Ricardo Flor Bertolini |
| author_sort | Juliana Sobral Antunes |
| collection | DOAJ |
| description | Background. To investigate the climb stairs resistance exercise on nociception and axonal regeneration in the sciatic nerve of rats. Methods. 24 Wistar rats were divided: control group (CG—no injury), exercise group (EG—no injury with physical exercise), lesion group (LG—injury, but without exercise), and treated group (LEG—injury and physical exercise). LG and LEG were subjected to sciatic nerve compression with hemostat. From the 3rd day after injury began treatment with exercise, and after 22 days occurs the removal of a nerve fragment for morphological analysis. Results. Regarding allodynia, CG obtained values less than EG (p=0.012) and larger than LG and LEG (p<0.001). Histological results showed that CG and EG had normal appearance, as LG and LEG showed up with large amounts of inflammatory infiltration, degeneration and disruption of nerve fibers, and reduction of the myelin sheath; however LEG presented some regenerated fibers. From the morphometric data there were significant differences, for nerve fiber diameter, comparing CG with LG and LEG and comparing axon diameter and the thickness of the myelin of the CG to others. Conclusion. Climb stairs resistance exercise was not effective to speed up the regenerative process of axons. |
| format | Article |
| id | doaj-art-5c39edd684e0410b8a9d5756bf6d4fbe |
| institution | Kabale University |
| issn | 1203-6765 1918-1523 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pain Research and Management |
| spelling | doaj-art-5c39edd684e0410b8a9d5756bf6d4fbe2025-02-03T01:03:02ZengWileyPain Research and Management1203-67651918-15232016-01-01201610.1155/2016/64871606487160Nociceptive and Neuronal Evaluation of the Sciatic Nerve of Wistar Rats Subjected to Compression Injury and Treated with Resistive ExerciseJuliana Sobral Antunes0Keli Lovison1Jhenifer Karvat2Ana Luiza Peretti3Lizyana Vieira4Guilherme Hideaki Higuchi5Rose Meire Costa Brancalhão6Lucinéia de Fátima Chasko Ribeiro7Gladson Ricardo Flor Bertolini8State University of Western Paraná (UNIOESTE), Universitaria Street, 2069, P.O. Box 711, 85819-110 Cascavel, PR, BrazilState University of Western Paraná (UNIOESTE), Universitaria Street, 2069, P.O. Box 711, 85819-110 Cascavel, PR, BrazilState University of Western Paraná (UNIOESTE), Universitaria Street, 2069, P.O. Box 711, 85819-110 Cascavel, PR, BrazilState University of Western Paraná (UNIOESTE), Universitaria Street, 2069, P.O. Box 711, 85819-110 Cascavel, PR, BrazilState University of Western Paraná (UNIOESTE), Universitaria Street, 2069, P.O. Box 711, 85819-110 Cascavel, PR, BrazilState University of Western Paraná (UNIOESTE), Universitaria Street, 2069, P.O. Box 711, 85819-110 Cascavel, PR, BrazilState University of Western Paraná (UNIOESTE), Universitaria Street, 2069, P.O. Box 711, 85819-110 Cascavel, PR, BrazilState University of Western Paraná (UNIOESTE), Universitaria Street, 2069, P.O. Box 711, 85819-110 Cascavel, PR, BrazilState University of Western Paraná (UNIOESTE), Universitaria Street, 2069, P.O. Box 711, 85819-110 Cascavel, PR, BrazilBackground. To investigate the climb stairs resistance exercise on nociception and axonal regeneration in the sciatic nerve of rats. Methods. 24 Wistar rats were divided: control group (CG—no injury), exercise group (EG—no injury with physical exercise), lesion group (LG—injury, but without exercise), and treated group (LEG—injury and physical exercise). LG and LEG were subjected to sciatic nerve compression with hemostat. From the 3rd day after injury began treatment with exercise, and after 22 days occurs the removal of a nerve fragment for morphological analysis. Results. Regarding allodynia, CG obtained values less than EG (p=0.012) and larger than LG and LEG (p<0.001). Histological results showed that CG and EG had normal appearance, as LG and LEG showed up with large amounts of inflammatory infiltration, degeneration and disruption of nerve fibers, and reduction of the myelin sheath; however LEG presented some regenerated fibers. From the morphometric data there were significant differences, for nerve fiber diameter, comparing CG with LG and LEG and comparing axon diameter and the thickness of the myelin of the CG to others. Conclusion. Climb stairs resistance exercise was not effective to speed up the regenerative process of axons.http://dx.doi.org/10.1155/2016/6487160 |
| spellingShingle | Juliana Sobral Antunes Keli Lovison Jhenifer Karvat Ana Luiza Peretti Lizyana Vieira Guilherme Hideaki Higuchi Rose Meire Costa Brancalhão Lucinéia de Fátima Chasko Ribeiro Gladson Ricardo Flor Bertolini Nociceptive and Neuronal Evaluation of the Sciatic Nerve of Wistar Rats Subjected to Compression Injury and Treated with Resistive Exercise Pain Research and Management |
| title | Nociceptive and Neuronal Evaluation of the Sciatic Nerve of Wistar Rats Subjected to Compression Injury and Treated with Resistive Exercise |
| title_full | Nociceptive and Neuronal Evaluation of the Sciatic Nerve of Wistar Rats Subjected to Compression Injury and Treated with Resistive Exercise |
| title_fullStr | Nociceptive and Neuronal Evaluation of the Sciatic Nerve of Wistar Rats Subjected to Compression Injury and Treated with Resistive Exercise |
| title_full_unstemmed | Nociceptive and Neuronal Evaluation of the Sciatic Nerve of Wistar Rats Subjected to Compression Injury and Treated with Resistive Exercise |
| title_short | Nociceptive and Neuronal Evaluation of the Sciatic Nerve of Wistar Rats Subjected to Compression Injury and Treated with Resistive Exercise |
| title_sort | nociceptive and neuronal evaluation of the sciatic nerve of wistar rats subjected to compression injury and treated with resistive exercise |
| url | http://dx.doi.org/10.1155/2016/6487160 |
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