Bilateral Basal Ganglion Hemorrhage after Severe Olanzapine Intoxication

Olanzapine is a second-generation antipsychotic drug which is generally considered safe with well therapeutic antipsychotic effects. We describe a patient suffering from bilateral intracerebral hemorrhage after severe olanzapine intoxication without underlying thrombocytopenia, arterial hypertension...

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Main Authors: Kerstin Schweyer, Bastian Fatke, Kornelia Kreiser, Christian Rabe, Christian Seifert, Benno Ikenberg
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Case Reports in Psychiatry
Online Access:http://dx.doi.org/10.1155/2020/2398721
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author Kerstin Schweyer
Bastian Fatke
Kornelia Kreiser
Christian Rabe
Christian Seifert
Benno Ikenberg
author_facet Kerstin Schweyer
Bastian Fatke
Kornelia Kreiser
Christian Rabe
Christian Seifert
Benno Ikenberg
author_sort Kerstin Schweyer
collection DOAJ
description Olanzapine is a second-generation antipsychotic drug which is generally considered safe with well therapeutic antipsychotic effects. We describe a patient suffering from bilateral intracerebral hemorrhage after severe olanzapine intoxication without underlying thrombocytopenia, arterial hypertension, or vascular malformation as cause of intracerebral hemorrhage. This raises the possibility of a direct side effect of high-dose olanzapine intake. So far, intracranial hemorrhage after olanzapine intoxication in such constellation has not been reported before. Given the high number of its prescription rates, our finding of intracranial hemorrhage after olanzapine intoxication is of high clinical relevance.
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institution Kabale University
issn 2090-682X
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language English
publishDate 2020-01-01
publisher Wiley
record_format Article
series Case Reports in Psychiatry
spelling doaj-art-5c33767fe47b46a485f60ec5f58226c92025-02-03T01:04:48ZengWileyCase Reports in Psychiatry2090-682X2090-68382020-01-01202010.1155/2020/23987212398721Bilateral Basal Ganglion Hemorrhage after Severe Olanzapine IntoxicationKerstin Schweyer0Bastian Fatke1Kornelia Kreiser2Christian Rabe3Christian Seifert4Benno Ikenberg5Technical University of Munich, School of Medicine, Klinikum rechts der Isar, Department of Neurology, München, GermanyTechnical University of Munich, School of Medicine, Klinikum rechts der Isar, Department of Psychiatry and Psychotherapy, München, GermanyTechnical University of Munich, School of Medicine, Klinikum rechts der Isar, Department of Neuroradiology, München, GermanyTechnical University of Munich, School of Medicine, Department of Clinical Toxicology & Poison Control Centre Munich, Klinikum rechts der Isar, München, GermanyTechnical University of Munich, School of Medicine, Klinikum rechts der Isar, Department of Neurology, München, GermanyTechnical University of Munich, School of Medicine, Klinikum rechts der Isar, Department of Neurology, München, GermanyOlanzapine is a second-generation antipsychotic drug which is generally considered safe with well therapeutic antipsychotic effects. We describe a patient suffering from bilateral intracerebral hemorrhage after severe olanzapine intoxication without underlying thrombocytopenia, arterial hypertension, or vascular malformation as cause of intracerebral hemorrhage. This raises the possibility of a direct side effect of high-dose olanzapine intake. So far, intracranial hemorrhage after olanzapine intoxication in such constellation has not been reported before. Given the high number of its prescription rates, our finding of intracranial hemorrhage after olanzapine intoxication is of high clinical relevance.http://dx.doi.org/10.1155/2020/2398721
spellingShingle Kerstin Schweyer
Bastian Fatke
Kornelia Kreiser
Christian Rabe
Christian Seifert
Benno Ikenberg
Bilateral Basal Ganglion Hemorrhage after Severe Olanzapine Intoxication
Case Reports in Psychiatry
title Bilateral Basal Ganglion Hemorrhage after Severe Olanzapine Intoxication
title_full Bilateral Basal Ganglion Hemorrhage after Severe Olanzapine Intoxication
title_fullStr Bilateral Basal Ganglion Hemorrhage after Severe Olanzapine Intoxication
title_full_unstemmed Bilateral Basal Ganglion Hemorrhage after Severe Olanzapine Intoxication
title_short Bilateral Basal Ganglion Hemorrhage after Severe Olanzapine Intoxication
title_sort bilateral basal ganglion hemorrhage after severe olanzapine intoxication
url http://dx.doi.org/10.1155/2020/2398721
work_keys_str_mv AT kerstinschweyer bilateralbasalganglionhemorrhageaftersevereolanzapineintoxication
AT bastianfatke bilateralbasalganglionhemorrhageaftersevereolanzapineintoxication
AT korneliakreiser bilateralbasalganglionhemorrhageaftersevereolanzapineintoxication
AT christianrabe bilateralbasalganglionhemorrhageaftersevereolanzapineintoxication
AT christianseifert bilateralbasalganglionhemorrhageaftersevereolanzapineintoxication
AT bennoikenberg bilateralbasalganglionhemorrhageaftersevereolanzapineintoxication