Visual experience orthogonalizes visual cortical stimulus responses via population code transformation
Summary: Sensory and behavioral experience can alter visual cortical stimulus coding, but the precise form of this plasticity is unclear. We measured orientation tuning in 4,000-neuron populations of mouse V1 before and after training on a visuomotor task. Changes to single-cell tuning curves appear...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Cell Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124725000063 |
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| author | Samuel W. Failor Matteo Carandini Kenneth D. Harris |
| author_facet | Samuel W. Failor Matteo Carandini Kenneth D. Harris |
| author_sort | Samuel W. Failor |
| collection | DOAJ |
| description | Summary: Sensory and behavioral experience can alter visual cortical stimulus coding, but the precise form of this plasticity is unclear. We measured orientation tuning in 4,000-neuron populations of mouse V1 before and after training on a visuomotor task. Changes to single-cell tuning curves appeared complex, including development of asymmetries and of multiple peaks. Nevertheless, these complex tuning curve transformations can be explained by a simple equation: a convex transformation suppressing responses to task stimuli specifically in cells responding at intermediate levels. The strength of the transformation varies across trials, suggesting a dynamic circuit mechanism rather than static synaptic plasticity. The transformation results in sparsening and orthogonalization of population codes for task stimuli. It cannot improve the performance of an optimal stimulus decoder, which is already perfect even for naive codes, but it improves the performance of a suboptimal decoder model with inductive bias as might be found in downstream readout circuits. |
| format | Article |
| id | doaj-art-5c2a7b2e6f5d4a4fab42b6bed08dce47 |
| institution | Kabale University |
| issn | 2211-1247 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj-art-5c2a7b2e6f5d4a4fab42b6bed08dce472025-01-31T05:11:14ZengElsevierCell Reports2211-12472025-02-01442115235Visual experience orthogonalizes visual cortical stimulus responses via population code transformationSamuel W. Failor0Matteo Carandini1Kenneth D. Harris2UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK; Corresponding authorUCL Institute of Ophthalmology, University College London, London EC1V 9EL, UKUCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK; Corresponding authorSummary: Sensory and behavioral experience can alter visual cortical stimulus coding, but the precise form of this plasticity is unclear. We measured orientation tuning in 4,000-neuron populations of mouse V1 before and after training on a visuomotor task. Changes to single-cell tuning curves appeared complex, including development of asymmetries and of multiple peaks. Nevertheless, these complex tuning curve transformations can be explained by a simple equation: a convex transformation suppressing responses to task stimuli specifically in cells responding at intermediate levels. The strength of the transformation varies across trials, suggesting a dynamic circuit mechanism rather than static synaptic plasticity. The transformation results in sparsening and orthogonalization of population codes for task stimuli. It cannot improve the performance of an optimal stimulus decoder, which is already perfect even for naive codes, but it improves the performance of a suboptimal decoder model with inductive bias as might be found in downstream readout circuits.http://www.sciencedirect.com/science/article/pii/S2211124725000063CP: Neuroscience |
| spellingShingle | Samuel W. Failor Matteo Carandini Kenneth D. Harris Visual experience orthogonalizes visual cortical stimulus responses via population code transformation Cell Reports CP: Neuroscience |
| title | Visual experience orthogonalizes visual cortical stimulus responses via population code transformation |
| title_full | Visual experience orthogonalizes visual cortical stimulus responses via population code transformation |
| title_fullStr | Visual experience orthogonalizes visual cortical stimulus responses via population code transformation |
| title_full_unstemmed | Visual experience orthogonalizes visual cortical stimulus responses via population code transformation |
| title_short | Visual experience orthogonalizes visual cortical stimulus responses via population code transformation |
| title_sort | visual experience orthogonalizes visual cortical stimulus responses via population code transformation |
| topic | CP: Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2211124725000063 |
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