Anti-Inflammatory and Prebiotic Potential of Ethanol Extracts and Mucilage Polysaccharides from Korean Yams (<i>Dioscorea polystachya</i> and <i>Dioscorea bulbifera</i>)
Korean yams are abundant in bioactive compounds with significant health-promoting properties. This study evaluated the anti-inflammatory potential of ethanol and water extracts from <i>Dioscorea polystachya</i> and <i>Dioscorea bulbifera</i> in RAW 264.7 macrophage cells. Amo...
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MDPI AG
2025-01-01
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| author | So-Yoon Park Van-Long Truong Su-Gyeong Jeon So-Young Choe Razanamanana H. G. Rarison Byoung-Hoon Yoon Ji-Won Park Hye-Jeong Jeong Woo-Sik Jeong |
| author_facet | So-Yoon Park Van-Long Truong Su-Gyeong Jeon So-Young Choe Razanamanana H. G. Rarison Byoung-Hoon Yoon Ji-Won Park Hye-Jeong Jeong Woo-Sik Jeong |
| author_sort | So-Yoon Park |
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| description | Korean yams are abundant in bioactive compounds with significant health-promoting properties. This study evaluated the anti-inflammatory potential of ethanol and water extracts from <i>Dioscorea polystachya</i> and <i>Dioscorea bulbifera</i> in RAW 264.7 macrophage cells. Among the extracts, the 95% ethanol extract exhibited the most potent inhibition of reactive oxygen species (ROS) and nitric oxide (NO) production, warranting further exploration of its mechanisms of action. Further analysis revealed that the ethanol extract modulated key inflammatory signaling pathways, including MAPK and NF-κB, contributing to its anti-inflammatory activity. Additionally, mucilage polysaccharides, a key bioactive component of Korean yams, were extracted and characterized for their structural and functional properties. These polysaccharides demonstrated immune-enhancing effects by reducing ROS and NO production while increasing phagocytic activity in the RAW 264.7 cells. Their prebiotic potential was also assessed through microbial growth assays, which showed an enhanced proliferation of beneficial bacteria such as <i>Lactobacillus</i> and <i>Bifidobacterium</i>. Furthermore, the adhesion assays using Caco-2 intestinal epithelial cells revealed that these polysaccharides promoted probiotic adhesion while inhibiting the adhesion of pathogenic bacteria. These findings highlight the bioactive potential of ethanol extracts and mucilage polysaccharides from Korean yams, emphasizing their promising applications as anti-inflammatory, immune-modulating, and prebiotic agents for functional food and nutraceutical development. |
| format | Article |
| id | doaj-art-5c221792f61e4f8c9de5cbc8f178d7cf |
| institution | Kabale University |
| issn | 2304-8158 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| series | Foods |
| spelling | doaj-art-5c221792f61e4f8c9de5cbc8f178d7cf2025-01-24T13:32:45ZengMDPI AGFoods2304-81582025-01-0114217310.3390/foods14020173Anti-Inflammatory and Prebiotic Potential of Ethanol Extracts and Mucilage Polysaccharides from Korean Yams (<i>Dioscorea polystachya</i> and <i>Dioscorea bulbifera</i>)So-Yoon Park0Van-Long Truong1Su-Gyeong Jeon2So-Young Choe3Razanamanana H. G. Rarison4Byoung-Hoon Yoon5Ji-Won Park6Hye-Jeong Jeong7Woo-Sik Jeong8School of Food Science & Biotechnology, College of Agriculture and Life Sciences, Kyungpook National University, Daegu 41566, Republic of KoreaSchool of Food Science & Biotechnology, College of Agriculture and Life Sciences, Kyungpook National University, Daegu 41566, Republic of KoreaInstitute for Bioresources Research, Gyeongsangbuk-do Agricultural Research and Extension Services, Andong 36614, Republic of KoreaInstitute for Bioresources Research, Gyeongsangbuk-do Agricultural Research and Extension Services, Andong 36614, Republic of KoreaSchool of Food Science & Biotechnology, College of Agriculture and Life Sciences, Kyungpook National University, Daegu 41566, Republic of KoreaSchool of Food Science & Biotechnology, College of Agriculture and Life Sciences, Kyungpook National University, Daegu 41566, Republic of KoreaSchool of Food Science & Biotechnology, College of Agriculture and Life Sciences, Kyungpook National University, Daegu 41566, Republic of KoreaSchool of Food Science & Biotechnology, College of Agriculture and Life Sciences, Kyungpook National University, Daegu 41566, Republic of KoreaSchool of Food Science & Biotechnology, College of Agriculture and Life Sciences, Kyungpook National University, Daegu 41566, Republic of KoreaKorean yams are abundant in bioactive compounds with significant health-promoting properties. This study evaluated the anti-inflammatory potential of ethanol and water extracts from <i>Dioscorea polystachya</i> and <i>Dioscorea bulbifera</i> in RAW 264.7 macrophage cells. Among the extracts, the 95% ethanol extract exhibited the most potent inhibition of reactive oxygen species (ROS) and nitric oxide (NO) production, warranting further exploration of its mechanisms of action. Further analysis revealed that the ethanol extract modulated key inflammatory signaling pathways, including MAPK and NF-κB, contributing to its anti-inflammatory activity. Additionally, mucilage polysaccharides, a key bioactive component of Korean yams, were extracted and characterized for their structural and functional properties. These polysaccharides demonstrated immune-enhancing effects by reducing ROS and NO production while increasing phagocytic activity in the RAW 264.7 cells. Their prebiotic potential was also assessed through microbial growth assays, which showed an enhanced proliferation of beneficial bacteria such as <i>Lactobacillus</i> and <i>Bifidobacterium</i>. Furthermore, the adhesion assays using Caco-2 intestinal epithelial cells revealed that these polysaccharides promoted probiotic adhesion while inhibiting the adhesion of pathogenic bacteria. These findings highlight the bioactive potential of ethanol extracts and mucilage polysaccharides from Korean yams, emphasizing their promising applications as anti-inflammatory, immune-modulating, and prebiotic agents for functional food and nutraceutical development.https://www.mdpi.com/2304-8158/14/2/173<i>Dioscorea polystachya</i><i>Dioscorea bulbifera</i>Korean yampolysaccharidesanti-inflammationimmune |
| spellingShingle | So-Yoon Park Van-Long Truong Su-Gyeong Jeon So-Young Choe Razanamanana H. G. Rarison Byoung-Hoon Yoon Ji-Won Park Hye-Jeong Jeong Woo-Sik Jeong Anti-Inflammatory and Prebiotic Potential of Ethanol Extracts and Mucilage Polysaccharides from Korean Yams (<i>Dioscorea polystachya</i> and <i>Dioscorea bulbifera</i>) Foods <i>Dioscorea polystachya</i> <i>Dioscorea bulbifera</i> Korean yam polysaccharides anti-inflammation immune |
| title | Anti-Inflammatory and Prebiotic Potential of Ethanol Extracts and Mucilage Polysaccharides from Korean Yams (<i>Dioscorea polystachya</i> and <i>Dioscorea bulbifera</i>) |
| title_full | Anti-Inflammatory and Prebiotic Potential of Ethanol Extracts and Mucilage Polysaccharides from Korean Yams (<i>Dioscorea polystachya</i> and <i>Dioscorea bulbifera</i>) |
| title_fullStr | Anti-Inflammatory and Prebiotic Potential of Ethanol Extracts and Mucilage Polysaccharides from Korean Yams (<i>Dioscorea polystachya</i> and <i>Dioscorea bulbifera</i>) |
| title_full_unstemmed | Anti-Inflammatory and Prebiotic Potential of Ethanol Extracts and Mucilage Polysaccharides from Korean Yams (<i>Dioscorea polystachya</i> and <i>Dioscorea bulbifera</i>) |
| title_short | Anti-Inflammatory and Prebiotic Potential of Ethanol Extracts and Mucilage Polysaccharides from Korean Yams (<i>Dioscorea polystachya</i> and <i>Dioscorea bulbifera</i>) |
| title_sort | anti inflammatory and prebiotic potential of ethanol extracts and mucilage polysaccharides from korean yams i dioscorea polystachya i and i dioscorea bulbifera i |
| topic | <i>Dioscorea polystachya</i> <i>Dioscorea bulbifera</i> Korean yam polysaccharides anti-inflammation immune |
| url | https://www.mdpi.com/2304-8158/14/2/173 |
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