Early-Onset Alzheimer’s Disease Masquerading as Catatonia
A 35-year-old woman with a history of sexual trauma was brought in by her family for further evaluation of depressive symptoms and progressive decline in activities of daily living. She was admitted to the inpatient psychiatric unit for the treatment of suspected catatonia. After failure to respond...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Neurological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2020/1493481 |
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| _version_ | 1832547703975837696 |
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| author | Aljoharah Alakkas Aaron Meyer Eric Debbold Raisa Yagudayeva Jonathan Bui |
| author_facet | Aljoharah Alakkas Aaron Meyer Eric Debbold Raisa Yagudayeva Jonathan Bui |
| author_sort | Aljoharah Alakkas |
| collection | DOAJ |
| description | A 35-year-old woman with a history of sexual trauma was brought in by her family for further evaluation of depressive symptoms and progressive decline in activities of daily living. She was admitted to the inpatient psychiatric unit for the treatment of suspected catatonia. After failure to respond to standard medical treatment, she received an extensive workup, which ultimately revealed a PSEN1 mutation consistent with early-onset Alzheimer’s disease. Diagnosis was challenging because of her young age, lack of reliable family history, and reports of recent sexual abuse by her biological father. This case is a cautionary reminder for clinicians that end stages of dementia can present similar to catatonia with mutism, lack of spontaneous movement, and refusal to eat. The clues to the diagnosis were profound cortical atrophy and lack of improvement with optimal medical management. |
| format | Article |
| id | doaj-art-5c1d376fbbf841cf847b070b486bb43b |
| institution | Kabale University |
| issn | 2090-6668 2090-6676 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Neurological Medicine |
| spelling | doaj-art-5c1d376fbbf841cf847b070b486bb43b2025-02-03T06:43:45ZengWileyCase Reports in Neurological Medicine2090-66682090-66762020-01-01202010.1155/2020/14934811493481Early-Onset Alzheimer’s Disease Masquerading as CatatoniaAljoharah Alakkas0Aaron Meyer1Eric Debbold2Raisa Yagudayeva3Jonathan Bui4University of California, San Diego, CA, USAUniversity of California, San Diego, CA, USAUniversity of California, San Diego, CA, USAUniversity of California, San Diego, CA, USAUniversity of California, San Diego, CA, USAA 35-year-old woman with a history of sexual trauma was brought in by her family for further evaluation of depressive symptoms and progressive decline in activities of daily living. She was admitted to the inpatient psychiatric unit for the treatment of suspected catatonia. After failure to respond to standard medical treatment, she received an extensive workup, which ultimately revealed a PSEN1 mutation consistent with early-onset Alzheimer’s disease. Diagnosis was challenging because of her young age, lack of reliable family history, and reports of recent sexual abuse by her biological father. This case is a cautionary reminder for clinicians that end stages of dementia can present similar to catatonia with mutism, lack of spontaneous movement, and refusal to eat. The clues to the diagnosis were profound cortical atrophy and lack of improvement with optimal medical management.http://dx.doi.org/10.1155/2020/1493481 |
| spellingShingle | Aljoharah Alakkas Aaron Meyer Eric Debbold Raisa Yagudayeva Jonathan Bui Early-Onset Alzheimer’s Disease Masquerading as Catatonia Case Reports in Neurological Medicine |
| title | Early-Onset Alzheimer’s Disease Masquerading as Catatonia |
| title_full | Early-Onset Alzheimer’s Disease Masquerading as Catatonia |
| title_fullStr | Early-Onset Alzheimer’s Disease Masquerading as Catatonia |
| title_full_unstemmed | Early-Onset Alzheimer’s Disease Masquerading as Catatonia |
| title_short | Early-Onset Alzheimer’s Disease Masquerading as Catatonia |
| title_sort | early onset alzheimer s disease masquerading as catatonia |
| url | http://dx.doi.org/10.1155/2020/1493481 |
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