Profiling the Resident and Infiltrating Monocyte/Macrophages during Rejection following Kidney Transplantation
Immune tolerance research is essential for kidney transplantation. Other than antibody and T cell-mediated immune rejection, macrophage-mediated innate immunity plays an important role in the onset phase of transplantation rejection. However, due to the complexity of the kidney environment as well a...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2020/5746832 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832546943134334976 |
|---|---|
| author | Jie Wang Peiling Luo Jingjie Zhao Junhua Tan Feifan Huang Ruiying Ma Peng Huang Meiying Huang Yuming Huang Qiuju Wei Liuzhi Wei Zechen Wang Lingzhang Meng |
| author_facet | Jie Wang Peiling Luo Jingjie Zhao Junhua Tan Feifan Huang Ruiying Ma Peng Huang Meiying Huang Yuming Huang Qiuju Wei Liuzhi Wei Zechen Wang Lingzhang Meng |
| author_sort | Jie Wang |
| collection | DOAJ |
| description | Immune tolerance research is essential for kidney transplantation. Other than antibody and T cell-mediated immune rejection, macrophage-mediated innate immunity plays an important role in the onset phase of transplantation rejection. However, due to the complexity of the kidney environment as well as its diversity and low abundance, studies pertaining to monocyte/macrophages in kidney transplantation require further elucidation. In this study, kidney samples taken from healthy human adults and biopsy specimens from patients undergoing rejection following kidney transplantation were analysed and studied. By conducting a single-cell RNA analysis, the type and status of monocyte/macrophages in kidney transplantation were described, in which monocyte/macrophages were observed to form two different subpopulations: resident and infiltrating monocyte/macrophages. Furthermore, previously defined genes were mapped to all monocyte/macrophage types in the kidney and enriched the differential genes of the two main subpopulations using gene expression databases. Considering that various cases of rejection may be of the monocyte/macrophage type, the present data may serve as a reference for studies regarding immune tolerance following kidney transplantation. |
| format | Article |
| id | doaj-art-5c081cf0809c462cb04f6eb9d7542f05 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-5c081cf0809c462cb04f6eb9d7542f052025-02-03T06:46:35ZengWileyJournal of Immunology Research2314-88612314-71562020-01-01202010.1155/2020/57468325746832Profiling the Resident and Infiltrating Monocyte/Macrophages during Rejection following Kidney TransplantationJie Wang0Peiling Luo1Jingjie Zhao2Junhua Tan3Feifan Huang4Ruiying Ma5Peng Huang6Meiying Huang7Yuming Huang8Qiuju Wei9Liuzhi Wei10Zechen Wang11Lingzhang Meng12Kidney Disease of Internal, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise City, Guangxi Province, ChinaGraduate School of Youjiang Medical University for Nationalities, Baise City, Guangxi Province, ChinaLife Science and Clinical Research Center, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise City, Guangxi Province, ChinaKidney Disease of Internal, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise City, Guangxi Province, ChinaKidney Disease of Internal, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise City, Guangxi Province, ChinaKidney Disease of Internal, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise City, Guangxi Province, ChinaKidney Disease of Internal, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise City, Guangxi Province, ChinaKidney Disease of Internal, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise City, Guangxi Province, ChinaKidney Disease of Internal, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise City, Guangxi Province, ChinaCenter for Systemic Inflammation Research (CSIR), School of Preclinical Medicine, Youjiang Medical University for Nationalities, Baise City, Guangxi Province, ChinaCenter for Systemic Inflammation Research (CSIR), School of Preclinical Medicine, Youjiang Medical University for Nationalities, Baise City, Guangxi Province, ChinaCenter for Systemic Inflammation Research (CSIR), School of Preclinical Medicine, Youjiang Medical University for Nationalities, Baise City, Guangxi Province, ChinaCenter for Systemic Inflammation Research (CSIR), School of Preclinical Medicine, Youjiang Medical University for Nationalities, Baise City, Guangxi Province, ChinaImmune tolerance research is essential for kidney transplantation. Other than antibody and T cell-mediated immune rejection, macrophage-mediated innate immunity plays an important role in the onset phase of transplantation rejection. However, due to the complexity of the kidney environment as well as its diversity and low abundance, studies pertaining to monocyte/macrophages in kidney transplantation require further elucidation. In this study, kidney samples taken from healthy human adults and biopsy specimens from patients undergoing rejection following kidney transplantation were analysed and studied. By conducting a single-cell RNA analysis, the type and status of monocyte/macrophages in kidney transplantation were described, in which monocyte/macrophages were observed to form two different subpopulations: resident and infiltrating monocyte/macrophages. Furthermore, previously defined genes were mapped to all monocyte/macrophage types in the kidney and enriched the differential genes of the two main subpopulations using gene expression databases. Considering that various cases of rejection may be of the monocyte/macrophage type, the present data may serve as a reference for studies regarding immune tolerance following kidney transplantation.http://dx.doi.org/10.1155/2020/5746832 |
| spellingShingle | Jie Wang Peiling Luo Jingjie Zhao Junhua Tan Feifan Huang Ruiying Ma Peng Huang Meiying Huang Yuming Huang Qiuju Wei Liuzhi Wei Zechen Wang Lingzhang Meng Profiling the Resident and Infiltrating Monocyte/Macrophages during Rejection following Kidney Transplantation Journal of Immunology Research |
| title | Profiling the Resident and Infiltrating Monocyte/Macrophages during Rejection following Kidney Transplantation |
| title_full | Profiling the Resident and Infiltrating Monocyte/Macrophages during Rejection following Kidney Transplantation |
| title_fullStr | Profiling the Resident and Infiltrating Monocyte/Macrophages during Rejection following Kidney Transplantation |
| title_full_unstemmed | Profiling the Resident and Infiltrating Monocyte/Macrophages during Rejection following Kidney Transplantation |
| title_short | Profiling the Resident and Infiltrating Monocyte/Macrophages during Rejection following Kidney Transplantation |
| title_sort | profiling the resident and infiltrating monocyte macrophages during rejection following kidney transplantation |
| url | http://dx.doi.org/10.1155/2020/5746832 |
| work_keys_str_mv | AT jiewang profilingtheresidentandinfiltratingmonocytemacrophagesduringrejectionfollowingkidneytransplantation AT peilingluo profilingtheresidentandinfiltratingmonocytemacrophagesduringrejectionfollowingkidneytransplantation AT jingjiezhao profilingtheresidentandinfiltratingmonocytemacrophagesduringrejectionfollowingkidneytransplantation AT junhuatan profilingtheresidentandinfiltratingmonocytemacrophagesduringrejectionfollowingkidneytransplantation AT feifanhuang profilingtheresidentandinfiltratingmonocytemacrophagesduringrejectionfollowingkidneytransplantation AT ruiyingma profilingtheresidentandinfiltratingmonocytemacrophagesduringrejectionfollowingkidneytransplantation AT penghuang profilingtheresidentandinfiltratingmonocytemacrophagesduringrejectionfollowingkidneytransplantation AT meiyinghuang profilingtheresidentandinfiltratingmonocytemacrophagesduringrejectionfollowingkidneytransplantation AT yuminghuang profilingtheresidentandinfiltratingmonocytemacrophagesduringrejectionfollowingkidneytransplantation AT qiujuwei profilingtheresidentandinfiltratingmonocytemacrophagesduringrejectionfollowingkidneytransplantation AT liuzhiwei profilingtheresidentandinfiltratingmonocytemacrophagesduringrejectionfollowingkidneytransplantation AT zechenwang profilingtheresidentandinfiltratingmonocytemacrophagesduringrejectionfollowingkidneytransplantation AT lingzhangmeng profilingtheresidentandinfiltratingmonocytemacrophagesduringrejectionfollowingkidneytransplantation |