Progress in Pathogenesis of Proteinuria
Aims. Proteinuria not only is a sign of kidney damage, but also is involved in the progression of renal diseases as an independent pathologic factor. Clinically, glomerular proteinuria is most commonly observed, which relates to structural and functional anomalies in the glomerular filtration barrie...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2012/314251 |
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| _version_ | 1832554494344298496 |
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| author | Aihua Zhang Songming Huang |
| author_facet | Aihua Zhang Songming Huang |
| author_sort | Aihua Zhang |
| collection | DOAJ |
| description | Aims. Proteinuria not only is a sign of kidney damage, but also is involved in the progression of renal diseases as an independent pathologic factor. Clinically, glomerular proteinuria is most commonly observed, which relates to structural and functional anomalies in the glomerular filtration barrier. The aim of this paper was to describe the pathogenesis of glomerular proteinuria. Data Sources. Articles on glomerular proteinuria retrieved from Pubmed and MEDLINE in the recent 5 years were reviewed. Results. The new understanding of the roles of glomerular endothelial cells and the glomerular basement membrane (GBM) in the pathogenesis of glomerular proteinuria was gained. The close relationships of slit diaphragm (SD) molecules such as nephrin, podocin, CD2-associated protein (CD2AP), a-actinin-4, transient receptor potential cation channel 6 (TRPC6), Densin and membrane-associated guanylate kinase inverted 1 (MAGI-1), α3β1 integrin, WT1, phospholipase C epsilon-1 (PLCE1), Lmx1b, and MYH9, and mitochondrial disorders and circulating factors in the pathogenesis of glomerular proteinuria were also gradually discovered. Conclusion. Renal proteinuria is a manifestation of glomerular filtration barrier dysfunction. Not only glomerular endothelial cells and GBM, but also the glomerular podocytes and their SDs play an important role in the pathogenesis of glomerular proteinuria. |
| format | Article |
| id | doaj-art-5c06d52fa9674e26add47d831576bdc3 |
| institution | Kabale University |
| issn | 2090-214X 2090-2158 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-5c06d52fa9674e26add47d831576bdc32025-02-03T05:51:22ZengWileyInternational Journal of Nephrology2090-214X2090-21582012-01-01201210.1155/2012/314251314251Progress in Pathogenesis of ProteinuriaAihua Zhang0Songming Huang1Department of Nephrology, Nanjing Children's Hospital, Nanjing Medical University, Nanjing 210008, ChinaDepartment of Nephrology, Nanjing Children's Hospital, Nanjing Medical University, Nanjing 210008, ChinaAims. Proteinuria not only is a sign of kidney damage, but also is involved in the progression of renal diseases as an independent pathologic factor. Clinically, glomerular proteinuria is most commonly observed, which relates to structural and functional anomalies in the glomerular filtration barrier. The aim of this paper was to describe the pathogenesis of glomerular proteinuria. Data Sources. Articles on glomerular proteinuria retrieved from Pubmed and MEDLINE in the recent 5 years were reviewed. Results. The new understanding of the roles of glomerular endothelial cells and the glomerular basement membrane (GBM) in the pathogenesis of glomerular proteinuria was gained. The close relationships of slit diaphragm (SD) molecules such as nephrin, podocin, CD2-associated protein (CD2AP), a-actinin-4, transient receptor potential cation channel 6 (TRPC6), Densin and membrane-associated guanylate kinase inverted 1 (MAGI-1), α3β1 integrin, WT1, phospholipase C epsilon-1 (PLCE1), Lmx1b, and MYH9, and mitochondrial disorders and circulating factors in the pathogenesis of glomerular proteinuria were also gradually discovered. Conclusion. Renal proteinuria is a manifestation of glomerular filtration barrier dysfunction. Not only glomerular endothelial cells and GBM, but also the glomerular podocytes and their SDs play an important role in the pathogenesis of glomerular proteinuria.http://dx.doi.org/10.1155/2012/314251 |
| spellingShingle | Aihua Zhang Songming Huang Progress in Pathogenesis of Proteinuria International Journal of Nephrology |
| title | Progress in Pathogenesis of Proteinuria |
| title_full | Progress in Pathogenesis of Proteinuria |
| title_fullStr | Progress in Pathogenesis of Proteinuria |
| title_full_unstemmed | Progress in Pathogenesis of Proteinuria |
| title_short | Progress in Pathogenesis of Proteinuria |
| title_sort | progress in pathogenesis of proteinuria |
| url | http://dx.doi.org/10.1155/2012/314251 |
| work_keys_str_mv | AT aihuazhang progressinpathogenesisofproteinuria AT songminghuang progressinpathogenesisofproteinuria |