Lack of Hypoxia Inducible Factor-1α Influences on Macrophages Ability to Deal with Leishmania braziliensis In Vitro and Affects Pathology In Vivo

Lack of Hypoxia Inducible Factor-1α Influences on Macrophages Ability to Deal with Leishmania braziliensis In Vitro and Affects Pathology In Vivo

Cutaneous leishmaniasis, caused by Leishmania braziliensis, still represents a serious health problem in Brazil, especially in the northeast region. Currently, to our knowledge, no report describes the role of hypoxia inducible factor-1α (HIF-1α) during L braziliensis infection. In this study, we de...

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Bibliographic Details
Main Authors: Rodrigo C.O. Sanches, Leonardo G. Vaz, Fabio V. Marinho, Erika S. Guimarães, Edgar M. Carvalho, Lucas P. Carvalho, Sergio C. Oliveira
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:JID Innovations
Subjects:
HIF-1α
Immunometabolism
Innate immunity
Leishmania braziliensis
Skin pathology
Online Access:http://www.sciencedirect.com/science/article/pii/S2667026725000013
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