Dilated Cardiomyopathy in Children and Adults: What is New?
Dilated cardiomyopathy (DCM) is the most common form of cardiomyopathy and cause of cardiac transplantation in children and young adults; mortality is high among this patient population. However, mortality, clinical course, and illustrative echocardiographic data of DCM in children and adults are no...
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2008.105 |
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| author | Galal E. Nagib Elkilany Mustafa A. AL-Qbandi Khaled A. Sayed Ibrahim Kabbash |
| author_facet | Galal E. Nagib Elkilany Mustafa A. AL-Qbandi Khaled A. Sayed Ibrahim Kabbash |
| author_sort | Galal E. Nagib Elkilany |
| collection | DOAJ |
| description | Dilated cardiomyopathy (DCM) is the most common form of cardiomyopathy and cause of cardiac transplantation in children and young adults; mortality is high among this patient population. However, mortality, clinical course, and illustrative echocardiographic data of DCM in children and adults are not well established. Our objective was to provide a research article of detailed descriptions of the incidence, causes, outcomes, related risk factors, and new echocardiographic criteria of risk of death from DCM. Our results showed that independent risk factors at DCM diagnosis for subsequent death or transplantation in children cohorts were older age, congestive heart failure, lower left ventricular ejection fraction (EF ≤ 25%), low global strain, significant mitral valve incompetence, pulmonary hypertension, diastolic dysfunction, right ventricular involvement, and cause of DCM (p < 0.001 for all). In adults, low ejection fraction (<30–35%), global peak systolic strain <-7.6%, increased EDV, ESV, LBBB, diastolic dysfunction, and left ventricle dyssynchrony were the main independent risk factors for major cardiac events and need for CRT or transplantation (p < 0.001 for all). Our conclusions were that in children and adults, DCM is a diverse disorder with outcomes that depend largely on cause, age, heart failure status at presentation, and echocardiographic parameters of the heart (systolic and diastolic function of left ventricle, pulmonary artery pressure, global strain, and valvular function of the mitral valve). This study will present new findings in the diagnostic area. |
| format | Article |
| id | doaj-art-5bf32a5f9b3646db9bdfc2fd4308d9db |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-5bf32a5f9b3646db9bdfc2fd4308d9db2025-02-03T01:24:16ZengWileyThe Scientific World Journal1537-744X2008-01-01876277510.1100/tsw.2008.105Dilated Cardiomyopathy in Children and Adults: What is New?Galal E. Nagib Elkilany0Mustafa A. AL-Qbandi1Khaled A. Sayed2Ibrahim Kabbash3Adult Cardiology Department, Echocardiography Laboratory, Chest Hospital, Safat, KuwaitPediatric Cardiology Department, Chest Hospital, Safat, KuwaitPediatric Cardiology Department, Chest Hospital, Safat, KuwaitPublic Health Department, Tanta Faculty of Medicine, EgyptDilated cardiomyopathy (DCM) is the most common form of cardiomyopathy and cause of cardiac transplantation in children and young adults; mortality is high among this patient population. However, mortality, clinical course, and illustrative echocardiographic data of DCM in children and adults are not well established. Our objective was to provide a research article of detailed descriptions of the incidence, causes, outcomes, related risk factors, and new echocardiographic criteria of risk of death from DCM. Our results showed that independent risk factors at DCM diagnosis for subsequent death or transplantation in children cohorts were older age, congestive heart failure, lower left ventricular ejection fraction (EF ≤ 25%), low global strain, significant mitral valve incompetence, pulmonary hypertension, diastolic dysfunction, right ventricular involvement, and cause of DCM (p < 0.001 for all). In adults, low ejection fraction (<30–35%), global peak systolic strain <-7.6%, increased EDV, ESV, LBBB, diastolic dysfunction, and left ventricle dyssynchrony were the main independent risk factors for major cardiac events and need for CRT or transplantation (p < 0.001 for all). Our conclusions were that in children and adults, DCM is a diverse disorder with outcomes that depend largely on cause, age, heart failure status at presentation, and echocardiographic parameters of the heart (systolic and diastolic function of left ventricle, pulmonary artery pressure, global strain, and valvular function of the mitral valve). This study will present new findings in the diagnostic area.http://dx.doi.org/10.1100/tsw.2008.105 |
| spellingShingle | Galal E. Nagib Elkilany Mustafa A. AL-Qbandi Khaled A. Sayed Ibrahim Kabbash Dilated Cardiomyopathy in Children and Adults: What is New? The Scientific World Journal |
| title | Dilated Cardiomyopathy in Children and Adults: What is New? |
| title_full | Dilated Cardiomyopathy in Children and Adults: What is New? |
| title_fullStr | Dilated Cardiomyopathy in Children and Adults: What is New? |
| title_full_unstemmed | Dilated Cardiomyopathy in Children and Adults: What is New? |
| title_short | Dilated Cardiomyopathy in Children and Adults: What is New? |
| title_sort | dilated cardiomyopathy in children and adults what is new |
| url | http://dx.doi.org/10.1100/tsw.2008.105 |
| work_keys_str_mv | AT galalenagibelkilany dilatedcardiomyopathyinchildrenandadultswhatisnew AT mustafaaalqbandi dilatedcardiomyopathyinchildrenandadultswhatisnew AT khaledasayed dilatedcardiomyopathyinchildrenandadultswhatisnew AT ibrahimkabbash dilatedcardiomyopathyinchildrenandadultswhatisnew |