Characterization and Antifungal Activity of Limonoid Constituents Isolated from Meliaceae Plants Melia dubia, Aphanamixis polystachya, and Swietenia macrophylla against Plant Pathogenic Fungi In Vitro
The plants of Meliaceae are native to tropical and subtropical regions as the Americas, west India, Southeast Asia, and Southern China. Many species of the genera Khaya, Swietenia, Aphanamixis, and Melia in this family are known as medicinal plants and have biological activities such as antiviral, a...
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Wiley
2021-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2021/4153790 |
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| author | Thanh Nguyen Tan Hieu Tran Trung Quang Le Dang Hien Vu Thi Hoang Dinh Vu Tuan Nguyen Ngoc Hoai Thu Thi Do Thanh Huong Nguyen Dang Ngoc Quang Thang Tran Dinh |
| author_facet | Thanh Nguyen Tan Hieu Tran Trung Quang Le Dang Hien Vu Thi Hoang Dinh Vu Tuan Nguyen Ngoc Hoai Thu Thi Do Thanh Huong Nguyen Dang Ngoc Quang Thang Tran Dinh |
| author_sort | Thanh Nguyen Tan |
| collection | DOAJ |
| description | The plants of Meliaceae are native to tropical and subtropical regions as the Americas, west India, Southeast Asia, and Southern China. Many species of the genera Khaya, Swietenia, Aphanamixis, and Melia in this family are known as medicinal plants and have biological activities such as antiviral, antimicrobial, antifeeding, insecticidal, and cytotoxic properties. The objectives of this research are to characterize and evaluate the bioactive limonoids from several plants of Meliaceae against phytopathogenic fungi. During the search of antifungal compounds from the plants of Meliaceae, the three methanol extracts of Melia dubia, Aphanamixis polystachya, and Swietenia macrophylla were found to suppress the mycelial growth of several phytopathogenic fungi. Nine limonoids isolated from M. dubia (1–2), A. polystachya (3–5), and S. macrophylla (6–9) were evaluated, for the first time, their antifungal effectiveness against nine phytopathogenic fungi Fusarium oxysporum, Magnaporthe oryzae, Sclerotium rolfsii, Rhizoctonia solani, Alternaria spp., and Botrytis cinerea, and three oomycetes Phytophthora species. Limonoids 2, 3, 6, and 8 displayed a remarkable broad-spectrum antifungal activity against all the test fungi. Sclerotium rolfsii was highly sensitive to the four limonoids with IC50 values ranging from 79.4 to 128.0 µg/mL. Notably, chisocheton compound G (3) isolated from A. polystachya and khayanolide B (8) isolated from S. macrophylla were the most potent antifungal limonoids and exhibited a dose-dependent activity against Phytophthora species. Compounds 2 and 9 displayed moderate activity against M. oryzae. Our study results demonstrated the discovery of antifungal and lead compounds from the group of limonoids for application in the control of fungal plant diseases. |
| format | Article |
| id | doaj-art-5bed925acb8a40b1a8dc9f4a6b4a56e7 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
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| series | Journal of Chemistry |
| spelling | doaj-art-5bed925acb8a40b1a8dc9f4a6b4a56e72025-02-03T05:43:46ZengWileyJournal of Chemistry2090-90632090-90712021-01-01202110.1155/2021/41537904153790Characterization and Antifungal Activity of Limonoid Constituents Isolated from Meliaceae Plants Melia dubia, Aphanamixis polystachya, and Swietenia macrophylla against Plant Pathogenic Fungi In VitroThanh Nguyen Tan0Hieu Tran Trung1Quang Le Dang2Hien Vu Thi3Hoang Dinh Vu4Tuan Nguyen Ngoc5Hoai Thu Thi Do6Thanh Huong Nguyen7Dang Ngoc Quang8Thang Tran Dinh9School of Chemistry Biology and Environment, Vinh University, Vinh, Nghean 43100, VietnamSchool of Natural Sciences Education, Vinh University, Vinh, Nghean 43100, VietnamR&D Center of Bioactive Compounds, Vietnam Institute of Industrial Chemistry, Hanoi 10000, VietnamHo Chi Minh City University of Natural Resources and Environment, Ho Chi Minh 72114, VietnamThe School of Chemical Engineering, Hanoi University of Science and Technology, Hanoi 10000, VietnamInstitute of Biotechnology and Food Technology, Industrial University of Ho Chi Minh City, Ho Chi Minh 71408, VietnamR&D Center of Bioactive Compounds, Vietnam Institute of Industrial Chemistry, Hanoi 10000, VietnamR&D Center of Bioactive Compounds, Vietnam Institute of Industrial Chemistry, Hanoi 10000, VietnamHanoi National University of Education, Hanoi 10000, VietnamInstitute of Biotechnology and Food Technology, Industrial University of Ho Chi Minh City, Ho Chi Minh 71408, VietnamThe plants of Meliaceae are native to tropical and subtropical regions as the Americas, west India, Southeast Asia, and Southern China. Many species of the genera Khaya, Swietenia, Aphanamixis, and Melia in this family are known as medicinal plants and have biological activities such as antiviral, antimicrobial, antifeeding, insecticidal, and cytotoxic properties. The objectives of this research are to characterize and evaluate the bioactive limonoids from several plants of Meliaceae against phytopathogenic fungi. During the search of antifungal compounds from the plants of Meliaceae, the three methanol extracts of Melia dubia, Aphanamixis polystachya, and Swietenia macrophylla were found to suppress the mycelial growth of several phytopathogenic fungi. Nine limonoids isolated from M. dubia (1–2), A. polystachya (3–5), and S. macrophylla (6–9) were evaluated, for the first time, their antifungal effectiveness against nine phytopathogenic fungi Fusarium oxysporum, Magnaporthe oryzae, Sclerotium rolfsii, Rhizoctonia solani, Alternaria spp., and Botrytis cinerea, and three oomycetes Phytophthora species. Limonoids 2, 3, 6, and 8 displayed a remarkable broad-spectrum antifungal activity against all the test fungi. Sclerotium rolfsii was highly sensitive to the four limonoids with IC50 values ranging from 79.4 to 128.0 µg/mL. Notably, chisocheton compound G (3) isolated from A. polystachya and khayanolide B (8) isolated from S. macrophylla were the most potent antifungal limonoids and exhibited a dose-dependent activity against Phytophthora species. Compounds 2 and 9 displayed moderate activity against M. oryzae. Our study results demonstrated the discovery of antifungal and lead compounds from the group of limonoids for application in the control of fungal plant diseases.http://dx.doi.org/10.1155/2021/4153790 |
| spellingShingle | Thanh Nguyen Tan Hieu Tran Trung Quang Le Dang Hien Vu Thi Hoang Dinh Vu Tuan Nguyen Ngoc Hoai Thu Thi Do Thanh Huong Nguyen Dang Ngoc Quang Thang Tran Dinh Characterization and Antifungal Activity of Limonoid Constituents Isolated from Meliaceae Plants Melia dubia, Aphanamixis polystachya, and Swietenia macrophylla against Plant Pathogenic Fungi In Vitro Journal of Chemistry |
| title | Characterization and Antifungal Activity of Limonoid Constituents Isolated from Meliaceae Plants Melia dubia, Aphanamixis polystachya, and Swietenia macrophylla against Plant Pathogenic Fungi In Vitro |
| title_full | Characterization and Antifungal Activity of Limonoid Constituents Isolated from Meliaceae Plants Melia dubia, Aphanamixis polystachya, and Swietenia macrophylla against Plant Pathogenic Fungi In Vitro |
| title_fullStr | Characterization and Antifungal Activity of Limonoid Constituents Isolated from Meliaceae Plants Melia dubia, Aphanamixis polystachya, and Swietenia macrophylla against Plant Pathogenic Fungi In Vitro |
| title_full_unstemmed | Characterization and Antifungal Activity of Limonoid Constituents Isolated from Meliaceae Plants Melia dubia, Aphanamixis polystachya, and Swietenia macrophylla against Plant Pathogenic Fungi In Vitro |
| title_short | Characterization and Antifungal Activity of Limonoid Constituents Isolated from Meliaceae Plants Melia dubia, Aphanamixis polystachya, and Swietenia macrophylla against Plant Pathogenic Fungi In Vitro |
| title_sort | characterization and antifungal activity of limonoid constituents isolated from meliaceae plants melia dubia aphanamixis polystachya and swietenia macrophylla against plant pathogenic fungi in vitro |
| url | http://dx.doi.org/10.1155/2021/4153790 |
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